Many cancer nonprofits' mission these days, all or in part, is to fund cancer research. If you are donating to or raising money by biking, swimming, walking for, or otherwise supporting cancer research then the challenge is to understand what is meant by the nonprofit when they say they fund cancer research.
"Cancer research ranges from epidemiology, molecular bioscience to the performance of clinical trials to evaluate and compare applications of the various cancer treatment. These applications include surgery, radiation therapy, chemotherapy, hormone therapy, Immunotherapy and combined treatment modalities such as chemo-radiotherapy."
The vast majority of cancer nonprofits are talking about research into conventional therapies such as surgery, radiation therapy, chemotherapy, hormone therapy, Immunotherapy and combined treatment modalities such as chemo-radiotherapy.
Raising money for conventional cancer research sounds great. However, few people would donate to or raise money if they understood that conventional cancer research might not benefit cancer survivors and caregivers. Most people want to know what their donations accomplish. The articles below outline some of the challenges with conventional cancer research.
The politics of basic academic cancer research versus commercial interests. Do research dollars fund basic research or do they fund commercial projects? Do donations pay for drug companies to bring products to market? Why do the researchers cited below care enough to quit?
Scientists Quit Texas Cancer Institute in Flap
"AUSTIN, Texas—Thirty-three scientists resigned from a state-funded cancer research institute this month, with some publicly complaining that political appointees were trying to improperly influence how its money was doled out...The Cancer Prevention and Research Institute of Texas, created in 2007 with a mission to spend $3 billion on cancer research and prevention by 2020-
"Some of the departing scientists—who include Nobel laureates Phillip A. Sharp and Alfred Gilman, who had been the institute's chief scientific officer—said in resignation letters and interviews with The Wall Street Journal that they were protesting a willingness by the oversight committee to fund commercial projects aimed at developing new cancer therapies, regardless of whether the projects had been thoroughly vetted by the scientists."
To read the entire article-
Lawmakers want answers from cancer-fighting agency
"Two Republican state lawmakers who helped create Texas' embattled $3 billion cancer-fighting effort are now demanding to know how it approved an $11 million grant to a biomedical company even though the proposal wasn't reviewed."
Today's research will take years to translate into possible therapies.
Breast cancer research sometimes misunderstood
Implication of cures just around the corner unrealistic, cancer survivor and researcher say
Posted: Sep 30, 2012 1:12 PM ET
"As thousands of Canadians walk and run to raise funds for breast cancer research this weekend, the reality is that much of the advances in scientific understanding will have little immediate impact on patients."
Clinical trials do not portray the real world of everyday cancer. Cancer patients may be older, may have other health problems, may be negatively effected by side effects- in short, controlled clinical trials are just that- controlled. Chances are pretty good that your experience will be less favorable than clinical trial results.
ASCO: Cancer Survival Lower in Real World
ASCO: Cancer Survival Lower in Real World
By Charles Bankhead, Staff Writer, MedPage Today
Lab Mistakes Hobble Cancer Studies But Scientists Slow to Take Remedies
April 20, 2012, 10:25 p.m. ET
"Last year, cancer researcher Robert Mandic got news no scientist wants to hear. After publishing a paper on a rare head-and-neck cancer, he learned the cells he had been studying were instead cervical cancer. He notified the journal Oral Oncology, which retracted the article...
Cancer experts seeking to solve the problem have found that a fifth to a third or more of cancer cell lines tested were mistakenly identified—with researchers unwittingly studying the wrong cancers, slowing progress toward new treatments and wasting precious time and money. In hundreds of documented cases that undermine a broad swath of research, cancer samples that were supposed to be one type of tumor have turned out to be another, through either careless laboratory handling, mislabeling or other mistakes.
It is a problem hiding in plain sight. Warnings to properly test cancer cell lines have sounded since the 1960s, a decade after scientists started making human cancer cell lines.
Study results are biased by the study's sponsors. The vast majority of all cancer research is paid for by for-profit companies.
Sponsoring by the Pharmaceutical Industry Can Bias the Results of Drug Studies, Study Suggests
"Drug studies financed by pharmaceutical companies frequently show positive results in favour of the sponsor...The authors conclude that pharmaceutical companies exploit a wide variety of possibilities of manipulating study results. Apart from financing the study, financial links to the authors, such as payments for lectures, may tend to make the results of the study more favourable for the company. Not only the results themselves, but also their interpretation, are significantly more often in accordance with the wishes of the sponsor."
Clinical Trials are... difficult. This last one is complicated. I will outline the issues below but my point is that the Food and Drug Administration (FDA) mandates controlled clinical trials with lots and lots of problems associated with them.
The Trials of Cancer Trials