Thymoquinone as Integrative Multiple Myeloma Therapy to Enhance Chemo

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“Our results show that Thymoquinone inhibited the proliferation of Multiple Myeloma cells irrespective of their sensitivity to doxorubicin, melphalan or bortezomib.”

If you have been diagnosed with multiple myeloma you are struggling to wrap your brain about the what is meant by both “a very treatable cancer” and “an incurable cancer.” I know I was confused by this when I was first diagnosed.

In a nutshell, conventional oncology has gotten pretty good at putting newly diagnosed MMers into remission. The challenge is that all MMers eventually relapse and become resistant to the long and growing list of FDA approved chemotherapy regimens.

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My belief as a MM survivor and MM cancer coach is that we must learn about and include evidence-based non-toxic therapies that can kill MM and/or integrate with conventional MM chemotherapy. Thymoquinone is an excellent example of what I am talking about.

Herbal Secrets Black Seed Oil Natural Dietary Supplement is a brand of thymoquinone that is Amazon’s best seller and well-reviewed.

Here is the MM Cancer Coaching guide for Integrative Therapies-

To learn the 17 different evidence-based non-toxic MM therapies click now-

Have you been diagnosed with MM? What symptoms? What stage?

David Emerson

  • MM Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer

Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model.

“Multiple myeloma (MM) is a B cell malignancy characterized by clonal proliferation of plasma cells in the bone marrow. With the advent of novel targeted agents, the median survival rate has increased to 5 -7 years…

However, majority of patients with myeloma suffer relapse or develop chemoresistance to existing therapeutic agents. Thus, there is a need to develop novel alternative therapies for the treatment of MM. Thus in the present study, we investigated whether thymoquinone (TQ), a bioactive constituent of black seed oil, could suppress the proliferation and induce chemosensitization in human myeloma cells and xenograft mouse model…

Our results show that TQ inhibited the proliferation of MM cells irrespective of their sensitivity to doxorubicin, melphalan or bortezomib. Interestingly, TQ treatment also resulted in a significant inhibition in the proliferation of CD138+ cells isolated from MM patient samples in a concentration dependent manner.

TQ also potentiated the apoptotic effects of bortezomib in various MM cell lines through the activation of caspase-3, resulting in the cleavage of PARP…

Furthermore, in a xenograft mouse model, TQ potentiated the antitumor effects of bortezomib…

Overall, our results demonstrate that TQ can enhance the anticancer activity of bortezomib in vitro and in vivo and may have a substantial potential in the treatment of MM.”

 

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