ADT for Prostate Cancer and Risk of Dementia and Depression

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“A growing body of evidence supports a link between androgen deprivation therapy (ADT) for prostate cancer and cognitive dysfunction…”


My uncle began ADT for his prostate cancer in the beginning of 2017. Uncle Ted had developed heart damage, gained weight and has become depressed over the past two years. To be fair, we are talking about a less than scientific evaluation of ADT. But if I were considering taking this therapy I would give serious concidertion to the non-toxic supplementation below.

Androgen Deprivation Therapy (ADT) causes a host of negative side effects. Our challenge as cancer patients and survivors is to learn how to minimize or eliminate the collateral damage done by toxic chemotherapy.

The first two articles establish ADT causing cognitive dysfunction in prostate cancer. The last article below discusses supplements and herbs that may reduce or diminish those side effects. I have linked products on Amazon that I think may be appropriate for the PCa patient.

By the way, Uncle Ted moved into an assisted living facility a couple of months ago. Coincidence?

Do you have prostate cancer? Are you considering ADT? Please scroll down the page, post a question or comment and I will reply to you ASAP.

David Emerson

  • Cancer Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:

Prostate Cancer- Balancing Conventional and Evidence-Based Non-Conventional

Red Wine and Green Tea Halt Prostate Cancer

The Better Prostate Cancer Diet- Mediterranean or Flexitarian?

Association Between Androgen Deprivation Therapy and Risk of Dementia.

“A growing body of evidence supports a link between androgen deprivation therapy (ADT) and cognitive dysfunction, including Alzheimer disease. However, it is currently unknown whether ADT may contribute to the risk of dementia more broadly…

Association of androgen deprivation therapy and depression in the treatment of prostate cancer: A systematic review and meta-analysis.

“There is increasing evidence that androgen deprivation therapy (ADT) may be associated with depression. Existing studies have shown conflicting results…

A total of 1,128 studies were initially identified and evaluated. A meta-analysis of 18 studies among 168,756 individuals found that ADT use conferred a 41% increased risk of depression..

The currently available evidence suggests that ADT in the treatment of prostate cancer is associated with an increased risk of depression…”

 The Use of Dietary Supplements to Alleviate Androgen Deprivation Therapy Side Effects during Prostate Cancer Treatment

“Approximately 90% of patients initially respond to ADT strategies, however many experience side effects including hot flashes, cardiotoxicity, metabolic and musculoskeletal alterations. This review summarizes pre-clinical and clinical studies investigating the ability of dietary supplements to alleviate adverse effects arising from ADT. In particular, we focus on herbal compounds, phytoestrogens, selenium (Se), fatty acids (FA), calcium, and Vitamins D and E. Indeed, there is some evidence that calcium and Vitamin D can prevent the development of osteoporosis during ADT. On the other hand, caution should be taken with the antioxidants Se and Vitamin E until the basis underlying their respective association with type 2 diabetes mellitus and PCa tumor development has been clarified…”



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Prostate Cancer? Avoid Overtreatment- Take These Steps Before Choosing Surgery or Radiation - PeopleBeatingCancer says 3 years ago

[…] ADT for Prostate Cancer and Risk of Dementia and Depression […]

Early Prostate Cancer? Know Your Options- PeopleBeatingCancer says 4 years ago

[…] ADT for Prostate Cancer and Risk of Dementia and Depression […]

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