Integrative Mesothelioma Therapy-Bromelain & Curcumin

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“Our data indicates that curcumin has a double effect on Malignant Mesothelioma cells through induction of pyroptosis while subsequently protecting against inflammation.”


Mesothelioma is a malignant cancer linked to exposure to asbestos. It commonly occurs in the lungs, abdomen and heart, and has a very poor prognosis. Physicians separate these types by the part of the mesothelium lining that’s affected, and the most common form is pleural mesothelioma of the lungs. Symptoms often include but aren’t limited to chest pain, shortness of breath, coughing, weight loss and lumps. There’s currently no cure for mesothelioma, and prevention is key. However aggressive forms of treatment, like Pneumonectomy, radiation and chemotherapy are readily available.


As a 20 plus year survivor of an incurable cancer I can attest to the importance of understanding “integrative” cancer therapy. In essence taking an integrative approach means that we thrown every known evidence-based therapy at our cancers. Me at multiple myeloma, you at mesothelioma.

Curcumin and an enzyme called bromelain are two such integrative therapies. By themselves they fight mesothelioma. Combined with conventional chemo they fight mesothelioma.

Curcumin has been well-studied for its ability to kill cancer in addition to integrate with chemotherapy to both enhance chemo’s efficacy while reducing its toxicity.

I supplement with Life Extension Super Bio Curcumin as this brand has been evaluated an approved by ConsumerLab.com, an independent testing service. Further, Life Extension’s formulation of Curcumin is said to be more bioavailable, more absorbable.

I supplement with Wobenzym N. Wobenzym N, is a combination of enzymes with bromelain comprising about 30%.

I am both a cancer survivor and cancer coachFor more information about non-conventional, integrative therapies and mesothelioma, scroll down the page, post a question or comment and I will reply ASAP.

Thank you,

David Emerson

  • Cancer Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

Curcumin: A Double Hit on Malignant Mesothelioma.

“Our data indicates that curcumin has a double effect on MM cells through induction of pyroptosis while subsequently protecting against inflammation.”

Bromelain

Bromelain is an extract derived from the stems of pineapples, although it exists in all parts of the fresh plant and fruit, which has many uses. The extract has a history of folk and modern medicinal use. As a supplement it is thought to have anti-inflammatory effects….

Systemic enzyme therapy (consisting of combinations of proteolytic enzymes such as bromelain, trypsin, chymotrypsin, and papain) has been investigated in Europe to evaluate the efficacy of proteolytic enzymes in the treatment of breast, colorectal, and plasmacytoma cancer patients.[6] In mice with experimental colitis, 6 months of dietary bromelain from pineapple stem or from fresh juice decreased the severity of colonic inflammation and reduced the number of cancerous lesions in the colon.[7]…”

Bromelain is one of the main ingredients in Wobenzym N in addition to the proteolytic enzymes trypsin, chymotrypsin, and papain.  I supplement with this broad spectrum enzyme combination daily when I supplement with Wobenzym N.”

Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma.

“Malignant peritoneal mesothelioma (MPM) expresses MUC1 and initial studies have shown that the viability of MPM cells is adversely affected by exposure to bromelain. Further, bromelain in combination with either 5-FU or cisplatin, the efficacy of the chemotherapeutic drug is enhanced. Hence, current evidence indicates that bromelain may have the potential of being developed into an effective anticancer agent for MPM.”

Anticancer effect of bromelain with and without cisplatin or 5-FU on malignant peritoneal mesothelioma cells

“The addition of bromelain increased the cytotoxicity of cisplatin significantly in both cell lines. However, 5-FU with bromelain did not show any significant increase in cytotoxicity. Bromelain-induced cell death is by apoptosis and autophagy. Bromelain has the potential of being developed as a therapeutic agent in MPM.”


The Most BioAvailable Curcumin Formulas

“Based on a review of these studies, it is evident that better bioavailability of formulated curcumin (CU) products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism”

A search of the Pubmed database for the word curcumin yields 601 studies spaning health topics from multiple myeloma and colorectal cancer, to chemotherapies that synergizes with CU, to Alzheimer’s Disease, arthritis and more. Based on years of reading studies and personal accounts, I think it is safe to say that CU supplementation is safe and relatively inexpensive.

I have read about myeloma patients taking daily doses of CU from 400 milligrams to 8 grams (1000 milligrams = 1 gram). By almost any measure, CU is a safe, inexpensive wonder drug.

The only challenge is that CU is famously difficult to absorb in the body. In other words, a person has to mix curcumin with some sort of fat (coconut oil, chocolate, etc.) or take a brand of curcumin capsule that is already formulated to be more “bioavailable” in order to derive the full benefit of CU.

The study linked and exerpted below reviews different formulations of CU. The study itself lists the three most bioavailable formulation/brand of CU and I’ve added an excerpt from a further review from Consumerlab.com that lists four additional bioavailable brands of CU.


Recommended Reading:


Curcumin

CU is a bright yellow chemical produced by some plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. It is sold as an herbal supplement, cosmetics ingredient, food flavoring, and food coloring.[1]

Bioavailable curcumin formulations: A review of pharmacokinetic studies in healthy volunteers.

“Curcumin is a widely studied natural compound which has shown tremendous in vitro therapeutic potential. Despite that, the clinical efficacy of the native CU is weak due to its low bioavailability and high metabolism in the gastrointestinal tract. During the last decade, researchers have come up with different formulations with a focus on improving the bioavailability of curcumin. As a result, a significant number of bioavailable curcumin-based formulations were introduced with the varying range of enhanced bioavailability.

The purpose of this review is to collate the published clinical studies of CU products with improved bioavailability over conventional (unformulated) CU. Based on the literature search, 11 curcumin formulations with available human bioavailability and pharmacokinetics data were included in this review. Further, the data on clinical study design, analytical method, pharmacokinetic parameters and other relevant details of each formulation were extracted.

Based on a review of these studies, it is evident that better bioavailability of formulated curcumin products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism. The review hopes to provide a quick reference guide for anyone looking information on these bioavailable curcumin formulations.

Based on the published reports,

exhibited over 100-fold higher bioavailability relative to reference unformulated CU. Suggested mechanisms accounting for improved bioavailability of the formulations and details on the bioanalysis methods are also discussed.”

According to Consumerlab.com:

“Novasol has the highest bioavailability (185 x compared to unforumulated CU), followed by Curcuwin (136 x), Longvida (100 x), Meriva (48 x), BCM-95 (27 x), Curcumin C3 Complex + Bioperene (20 x), and then Theracumin (16 x).”

 

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