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Recently Diagnosed or Relapsed? Stop Looking For a Miracle Cure, and Use Evidence-Based Therapies To Enhance Your Treatment and Prolong Your Remission

Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.

Click the orange button to the right to learn more about what you can start doing today.

DCA enhances Velcade in Multiple Myeloma

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Dichloracetate (DCA) enhances the efficacy of Velcade, a standard-of-care Multiple Myeloma Therapy

Multiple Myeloma (MM) is considered incurable by conventional oncology. In other words, if an MM patient only pursues conventional MM therapies, he/she will experience remission, relapse, remission, relapse and finally,there is nothing more that we can do for you.” That’s what happened to me anyway.

Therefore, in my opinion, MMers must think outside the conventional therapy box.

According to the study below Dichloroacetate (DCA) enhances the efficacy of Velcade. An MM patient can either make the standard dose of Velcade work better or reduce the standard dose possibly reducing the toxicity of Velcade and experiencing less toxicity aka fewer side effects.

Further, there are other non-conventional therapies, such as CBD oil and curcumin that have shown the ability to both kill mm cells as well as enhance the efficacy of Velcade.

I am both a long-term multiple myeloma survivor and myeloma cancer coach. I have remained in complete remission from my multiple myeloma since 1999 by living an evidence-based, non-toxic, anti-MM lifestyle through:

  • nutrition,
  • anti-oxidant, anti-angiogenic supplementation,
  • bone health therapies,
  • detox therapies,
  • mind-body therapies and more.

Please scroll down the page, post a question or a comment if you’d like to learn more about both conventional FDA approved MM therapies as well as evidence-based MM therapies.

Thank you,

David Emerson

  • Multiple Myeloma survivor,
  • Multiple Myeloma Cancer Coach
  • Director, PeopleBeatingCancer

Recommended Reading:


Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib (Velcade)

Background:

Dichloroacetate (DCA), through the inhibition of aerobic glycolysis (the ‘Warburg effect’) and promotion of pyruvate oxidation, induces growth reduction in many tumors and is now undergoing several clinical trials. If aerobic glycolysis is active in multiple myeloma (MM) cells, it can be potentially targeted by DCA to induce myeloma growth inhibition.

Methods:

Representative multiple myeloma cell lines and myeloma-bearing mice were treated with DCA, alone and in combination with bortezomib.

Results:

We found that aerobic glycolysis occurs in approximately half of MM cell lines examined, producing on average 1.86-fold more lactate than phorbol myristate acetate stimulated-peripheral blood mononuclear cells and is associated with low-oxidative capacity. Lower doses of DCA (5–10 mM) suppressed aerobic glycolysis and improved cellular respiration that was associated with activation of the pyruvate dehydrogenase complex. Higher doses of DCA (10–25 mM) induced superoxide production, apoptosis, suppressed proliferation with a G0/1and G2M phase arrest in MM cell lines. In addition, DCA increased MM cell line sensitivity to bortezomib, and combinatorial treatment of both agents improved the survival of myeloma-bearing mice.

Conclusion:

Myeloma cells display aerobic glycolysis and DCA may complement clinically used MM therapies to inhibit disease progression.

Dichloroacetate and cancer: a new home for an orphan drug?

“These findings and limited clinical results suggest that potentially fruitful areas for additional clinical trials include 1) adult and pediatric hhigh-gradeastrocytomas; 2) BRAF-mutant cancers, such as melanoma, perhaps combined with other pro-oxidants; 3) tumors in which resistance to standard platinum-class drugs alone may be overcome with combination therapy; and 4) tumors of endodermal origin, in which extensive experimental research has demonstrated significant anti-proliferative, pro-apoptotic effects of DCA, leading to improved host survival.”

 

Leave a Comment:

27 comments
Jonathan says last year

My Partner has been diagnosed with MM ISS stage 2, we’re familiar with DCA she has been offered Velcade, could she take a lower dose with DCA as her first treatment? Thank you

Reply
    David Emerson says last year

    Hi Jonathan-

    I am sorry to read of your partner’s MM diagnosis. You are correct. According to the article about DCA linked in the blog post you came in on, ” In addition, DCA increased MM cell line sensitivity to bortezomib, and combinatorial treatment of both agents improved the survival of myeloma-bearing mice.”

    The challenge is, that study was conducted in mice. Therefore DCA would be considered a non-conventional, not approved by the FDA integrative therapy.

    Based on my research and experience as a long-term MM survivor, MM patients must consider both FDA approved therapies such as Velcade as well as evidence-based but non-conventional therapies such as DCA, curcumin (also synergizies with Velcade), anti-angiogenic nutrition and lifestyle therapies such as whole body hyperthermia.

    I know it may sound complicated but MM is a complicate blood cancer.

    Let me know if you have any other questions. Good luck and hang in there,

    David Emerson

    Reply
      Jonathan says last year

      Thank you for your reply David and also for what you are doing here for people, I wish you all the best.

      Reply
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Ronald says 5 years ago

Hi David,
My onc is suggesting Bortezomib injection. This is suppose to kill myeloma cancer cells. Does it kill other cells as well? I am also taking Omega 3, resveritrol, milk thistle and curcumin vitamins. Do you think this will help?

Reply
    David Emerson says 5 years ago

    Hi Ron-

    Bortezomib aka Velcade has been shown to kill MM. Injection of Velcade has been shown to reduce the risk of CIPN- chemo induced peripheral neuropathy. Cytotoxic chemotherapy drugs also kill normal cells. Omega 3 fatty acids, curcumin, and other integrative therapies have been shown to integrate with Velcade enhancing its efficacy in MM.

    If you would like to see the research for the above as well as for other evidence-based, non-toxic integrative therapies as well as anti-MM nutrition, supplementation, bone health, lifestyle and mind-body therapies consider becoming a myeloma cancer coaching client.

    What stage of MM was your original diagnosis? Have you previously undergone any chemotherapy or radiation? Are you experiencing any symptoms such as bone damage, anemia or kidney damage?

    Thanks,

    David Emerson

    Reply
odoes to alLaudrick Dalzell says 5 years ago

Very good article, very informative and codoes to all survivors and those of us still in the trenches the motto and will always be “WE WILL NEVER GIVE UP”

Reply
Laudrick Dalzell says 5 years ago

Can you use CBD,Curcumin and Resveritrol together? if NOT what’s? the best way to use these products for treatment?

Reply
    David Emerson says 5 years ago

    Hi Laudrick-

    What type of cancer and what stage? I supplement with both curcumin and resveritrol daily. I cannot access CBD as I live in Ohio.

    David

    Reply
Laudrick Dalzell says 5 years ago

HI David, do you use CBD,Curcumin and Resveritrol together? If not, what the best way to use these products?

Reply
mandy says 6 years ago

Hi my dog has stage 3 cancer n her mammary gland would dca help r would I b better going for cbd n thc please any help b great. Mandy

Reply
    David Emerson says 6 years ago

    Hi Mandy-

    I am sorry to learn of your dog’s cancer. I know very little about canine cancer. When my dog Maisy was diagnosed with canine melanoma I followed the same basic philosophy that I pursued with my own cancer. And that philosophy is that toxic therapies will limit a dog’s quality of life and may or may not add any length of life.

    Maisy underwent surgery twice to debulk the cancer. Each surgery allowed approx. 18 months before the cancer returned. There was a short recovery period but no side effects that I could see.

    Please let me know if you have any questions.

    David Emerson

    Reply
Sarah says 7 years ago

Hi there. I came across your website while doing some research. My dad was diagnosed with mm a little over 2 years ago. Has had a stem cell transplant and a strong dose of chemo and he went into remission for a few months. It came back and he has been on many different lines of medication. He just exhausted his last one. He was admitted into the hospital today as his IGA jumped from 27 to 46 in just 4 weeks. They are starting him on valcaid again for the 3rd time just to see if he will respond. Basically there isn’t anything else they can do. He is feeling really good aside from chronic constipation from all the chemo treatments. His kidney function is good and his bones are strong. I am looking at hemp oil and thats how I came across your site. My parents are willing to do anything at this point. Is DCA hemp oil or is it something different. Thank you so much for any info you might have!

Reply
    David Emerson says 7 years ago

    Hi Sarah-

    Your account of your dad’s MM experiences are similar to many MMers I work with, many in the chat room/forums I participate in. Several issues in response to your questions.

    DCA stands for dichloroacetate. DCA is an integrative therapy that may potentiate Velcade for your dad. The difficulty you and I have in understanding non-conventional therapies like DCA is that they are not well researched. Information is thin.

    Other therapies that have been shown to enhance the efficacy of Velcade (aka make it work better…) is Cannabis aka CBD. Again, the research is thin. Add that Med. Mar. is illegal in some states… again, it is difficult to make a decision.

    Curcumin is an anti-oxidant, anti-angiogenic supplement that 1) has shown the ability to kill myeloma and 2) also potentiates the efficacy of Velcade. This supplement has been studied pretty well and many MMers use it. I do even though I have been in remission since ’99. I will link studies below and I will link the brand I take that I buy through Amazon.

    Omega 3 fatty acids also kill MM and potentiate Velcade- see the links below-

    Lastly, please consider resveritrol. Like curcumin this is also fights MM and potentiates Velcade.

    I’m not an oncologist so I can’t tell you what to do at this point but I will tell you that the two supplements above have helped me stay MM free-
    Curcumin in Multiple Myeloma
    Omega-3 fatty acids (aka fish oil) kills multiple myeloma and enhances Velcade
    Resveritrol, Velcade

    Brands that I use-
    Curcumin-
    Omega 3 fatty acids
    Resveritrol-

    While I can’t provide you the research, I have read anecdotal accounts that these supplements potentiate each other when taken together. As for dosages, I would follow the label. The curcumin brand that I showed you is supposed to be many times more bio available- better absorbed in your blood.

    I think there is reason to think that both DCA and CBD enhance Velcade, I’m not talking about these only because I don’t know much, I don’t take them, I don’t read about them. If you lived in Canada where CBD is legal I would tell you to go for it…

    Let me know if you have any questions.

    Take it easy and hang in there.

    David Emerson

    Reply
      Sarah says 7 years ago

      Hi David,

      Thank you for your quick reply. My dad lives in Canada so he can do the hemp oil. hemp oil is CBD, correct? His doctor is potentially putting him back on valcade. I also will order the curcumin and omega 3. Can we use all the curcumin, omega 3 and hemp oil all at the same time? We are desperate and willing to try anything. If he isn’t on the valcade can taking all these things still be effective? Thank you so much for the information. Your information is the first hope I’ve had in some time.
      Thanks!

      Sarah

      Reply
Sylvia says 7 years ago

My husband has extramedullary myeloma and presented with a major mass to his pancreas. He had a BMT in Dec. 2014 but the myeloma returned in March very aggressively with none in the bone marrow. I’ve read lots about DCA & Velcade (bortezomib)together. He has stopped responding to Velcade now. Have you (or anyone you know) used DCA with Velcade. If so what were the results?

Reply
    David Emerson says 7 years ago

    Hi Sylvia-

    I am sorry to learn of your husband’s ex myeloma. I belong to several cancer forums and while DCA is mentioned occasionally, I know of no MMers who talk about DCA therapy. Further, I searched for DCA with myeloma on the Internet and I could find nothing relevant.

    If you and your husband are/were satisfied with Velcade, consider reading these posts- there is mention of integrative therapies increasing the MM to velcade once again.
    Omega-3 fatty acids (aka fish oil) kills multiple myeloma and enhances Velcade
    Curcumin in Multiple Myeloma

    Let me know if you have any questions.

    David Emerson

    Reply
p says 7 years ago

I would like to know about DCA treatment in multiple myeloma. I have already use a lot of therapies: velcate, caelyx, dexamethazone, doxorubicin and others. Can i use DCA?

Thank you!

Reply
    David Emerson says 7 years ago

    Hi P-

    Regarding your question ” I have already use a lot of therapies: velcate, caelyx, dexamethazone, doxorubicin and others. Can i use DCA?” the short answer is that I can’t say conclusively. There just isn’t enough research.

    The long answer is that the article linked below cites a number of trials for DCA combined with many chemotherapies and the studies talk about DCA enhancing the efficacy of the chemo. Scroll way down the page.

    The short annoying answer is what choices do you have? I don’t mean to be annoying but it sounds as though you have been managing your mm for a while now using a host of chemotherapies. Since I noticed that revlimid is not on the list, consider this chemo and combine it with both curcumin and resveritrol. Another therapy to consider.

    Let me know if you have any questions. David

    Potential cancer drug DCA tested in early trials

    Reply
David Emerson says 7 years ago

sent

Reply
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