Recently Diagnosed or Relapsed? Stop Looking For a Miracle Cure, and Use Evidence-Based Therapies To Enhance Your Treatment and Prolong Your Remission
Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
Click the orange button to the right to learn more about what you can start doing today.
“The findings of this study shed a new light with respect to some of the novel mechanisms underlying the antitumor action of Dichloroacetate (DCA) and thus may have immense clinical applications.”
On the one hand, I believe that there is no such thing as a magic bullet cancer therapy. One therapy will never be able to get rid of all cancers at all stages in all people.
However, I do think that there are therapies that are:
non-toxic-few if any side effects
non-conventional- not FDA approved
reasonably priced- not cheap but not going to bankrupt you-
integrative with conventional MM therapy- they enhance the efficacy of standard-of-care MM chemo-
The challenge is to find “evidence-based” research. Again, not the kind of research that conventional oncology may require to approve a therapy for the standard-of-care but enough evidence to elevate the therapy above hearsay and anecdotal testimonials.
Most importantly, the second study linked and excerpted below indicates that DCA is the ideal integrative myeloma therapy- that is, DCA is cytotoxic to MM by itself and it enhances the efficacy of a standard-of-care MM chemotherapy regimen called bortezomib aka Velcade.
For more information about DCA in addition to other evidence-based, conventional and non-conventional myeloma therapies, scroll down the page, post a question or comment and I will reply ASAP.
Although preliminary studies have shown DCA can slow the growth of certain tumors in animal studies and in vitro studies, “Available evidence does not support the use of DCA for cancer treatment at this time.”[3]“
“Myeloma cells display aerobic glycolysis and DCA may complement clinically used MM therapies to inhibit disease progression…
Dichloroacetate induced apoptosis and inhibited the proliferation of MM cell lines- As DCA-mediated increases in superoxide production can lead to apoptosis (Cao et al, 2008; Michelakis et al, 2008)..
Dichloroacetate increased the sensitivity of MM cell lines to the chemotherapeutic drug bortezomib-However, DCA administered in combination with bortezomib significantly prolonged (**P<0.01) the survival of myeloma-bearing mice compared with control mice (overall survival: DCA+bortezomib-treated mice 28.5 days vs control mice 22 days; Figure 5A). After 18 days of treatment, neither DCA alone or DCA+bortezomib treatment affected serum lambda concentration compared with that in control mice (Figure 5B). However, bortezomib administered alone significantly reduced (*P<0.05) serum lambda concentration compared with that of control mice (Figure 5B).
Over the past year or two there have been several articles in the news and on the internet about DCA, which was claimed to be cheap, safe and “kill most cancers”.
Understandably this caused a great deal of interest, especially as DCA is an off-patent drug and appears to be non-toxic to humans (although it can cause significant side effects, as we’ll see later).”
Targeting of tumor metabolism is emerging as a novel therapeutic strategy against cancer. Dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase kinase (PDK), has been shown to exert a potent tumoricidal action against a variety of tumor cells…
The findings of this study shed a new light with respect to some of the novel mechanisms underlying the antitumor action of DCA and thus may have immense clinical applications.”
Since you came in on the blog post about DCA and MM I will assume that you are asking about DCA as a MM therapy. The research is sparse. The bad news is that I have no personal experience with DCA and the studies that I have seen are based on DCA’s affect on other solid tumors. The good news is that according to the study linked below, DCA enhances MM’s sensitivity to bortezomib aka velcade.
DCA’s ability to synergize with conventional MM therapies fits with the several evidenced based, non-conventional therapies that also are integrative with MM chemo regimens. None of the studies I’ve found give clear dose info. My approach is to approach DCA in the same way that MMer’s approach other integrative therapies such as curcumin, resveritrol, green tea extract, etc.
I will forward any comments from cured patients who contact me. Keep in mind that I consider myself to be cured of my cancer, multiple myeloma. I’ve been complete remission since 4/99.
