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Mesothelioma Patients Must Think Both Inside and Outside the Box

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The new therapy is more effective and less toxic than doxorubicin alone…Tumours shrank, the cancer cells proliferated less…

Current studies indicate that the majority of cancer patients undergoing conventional therapies believe that the treatment is “curative.” Meaning these patients believe that they might be cured. Mesothelioma is currently an incurable cancer. “Current treatments, including surgery and chemotherapy, have limited efficacy and unpleasant side effects..”

The point of the article linked below is for the mesothelioma patient to think outside the box. Find an oncologist that specializes in mesothelioma and ask him/her about therapies beyond the “standard-of-care.”

The fact is that there are a host of evidence-based non-conventional therapies that have been shown to either enhance the efficacy of meso chemotherapy or kill meso by itself.

I am a long-term cancer survivor and cancer coach. I work with cancer patients and survivors to research and identify both conventional and evidence-based non-conventional therapies to enhance both length of life and quality of life.

To learn more about mesothelioma therapies, both conventional and non-conventional, scroll down the page, post a question or comment and I will reply ASAP.

Thank you,

David Emerson

  • Cancer survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:

Mesothelioma Diagnosis- Oncologists who Specialize Can Make a Difference


Mesothelioma: A Targeted Approach to Asbestos-Related Cancer

A new targeted therapy for asbestos-related tumours has shown promise in an animal model. The results, raise hopes of a new therapy for this currently incurable cancer…Malignant mesothelioma (MMs) is a rare form of cancer, most commonly caused by exposure to asbestos. It tends to be diagnosed decades after exposure occurs, so is rarely caught early. Current treatments, including surgery and chemotherapy, have limited efficacy and unpleasant side effects...

The new therapy is more effective and less toxic than doxorubicin alone…Tumours shrank, the cancer cells proliferated less, and the animals were able more or less to maintain their weight and health throughout the treatment. Overall, the data suggest that targeted therapy may prove better than chemotherapy alone…

Using this targeting approach, the authors were able to reduce the dose of doxorubicin used four-fold thus almost eliminating side effects and toxicity. And because the treatment appears to reduce the number of proliferating tumour cells, it may prove useful early on, when pre-malignant or malignant MM cells are first observed, but before disease has been confirmed by histology.”

Microspheres targeted with a mesothelin antibody and loaded with doxorubicin reduce tumor volume of human mesotheliomas in xenografts

“Results– Targeted therapy (APMS-MB-DOX at 0.05 mg/kg) was more effective than DOX low (0.05 mg/kg) and less toxic than treatment with DOX high (0.2 mg/kg). It also resulted in the reduction of tumor volume without loss of animal health and weight, and significantly decreased tumor cell proliferation. High pressure liquid chromatography (HPLC) of tumor tissue confirmed that APMS-MB-DOX particles delivered DOX to target tissue.

Conclusions- Data suggest that targeted therapy results in greater chemotherapeutic efficacy with fewer adverse side effects than administration of DOX alone. Targeted microparticles are an attractive option for localized drug delivery.”

Mesothelioma Treatment- Think Outside the Box

We previously reported a synergistic anti-proliferative effect of resveratrol and clofarabine against malignant mesothelioma (MM) cells…

There are two important things for mesothelioma (meso) survivors and caregivers to keep in mind. First, conventional oncology considers mesothelioma to be an incurable cancer with a poor prognosis. Secondly,  meso patients and caregivers must think outside the box when it comes to cancer management.

My cancer, multiple myeloma,  is very different from mesothelioma. However, like mesothelioma, is considered to be incurable by conventional oncology. After several years of aggressive conventional therapies including an autologous stem cell transplant, remission, relapse, remission, relapse and we can do nothing more for you, I underwent a series of non-conventional anti-myeloma that put me into remission where I remain today.

I have lived with my incurable cancer now since ’94 because I have learned to think outside the box.

The four studies linked and excerpted below talk about non-toxic therapies that are cytotoxic (kill) to meso and are supported by research. I encourage you too to think outside the conventional oncology box.

Resveratrol contributes to chemosensitivity of malignant mesothelioma cells with activation of p53.

“Resveratrol is a naturally occurring polyphenolic phytoalexin with chemopreventive properties. We previously reported a synergistic anti-proliferative effect of resveratrol and clofarabine against malignant mesothelioma (MM) cells…”

Natural diterpenes from coffee, cafestol and kahweol induce apoptosis through regulation of specificity protein 1 expression in human malignant pleural mesothelioma.

“The therapeutic activities of the bioactive compounds in coffee was sugested to influence intracellular signaling of MPM. Regarding to the cancer-related functions, In this study, suppression of Sp1 protein level followed by induction of MSTO-211H cell apoptosis by cafestol and kahweol were investigated in oreder to determine Sp1’s potential as a significant target for human MPM therapy as well.”

Role of transcription factor Sp1 in the quercetin-mediated inhibitory effect on human malignant pleural mesothelioma.

“Our results strongly suggest that Sp1 be considered as a novel molecular target of Qu in human malignant pleural mesothelioma.”

Downregulation of Sp1 is involved in honokiol-induced cell cycle arrest and apoptosis in human malignant pleural mesothelioma cells.

“The results revealed that HNK significantly reduced the cell viability and increased the sub-G1 population in MSTO-211H cells and suppressed the expression of the specificity protein 1 protein (Sp1). HNK reduced the transcriptional activity of Sp1 regulatory proteins, including cyclin D1, Mcl-1 and survivin, and, thus, induced apoptosis signaling pathways by increasing Bax, reducing Bid and Bcl-xl and activating caspase-3 and PARP in mesothelioma cells. The results suggest that Sp1, a novel molecular target of HNK, may be related to cell cycle arrest and apoptosis induction through the modulation of signal transduction pathways in MPM.”

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