Atypical Mole Syndrome and Dysplastic Nevi- Melanoma Risk

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“Atypical Mole Syndrome is the most important phenotypic risk factor for developing cutaneous melanoma…”

If you have AMS and if your family is affected by AMS then, according to the study linked and excerpted below, your risk of mel. increases dramatically.

While the proposed solution to this increased risk, at least as far as the article is concerned, is to monitor your skin regularly.

My belief as a long-term cancer survivor and cancer coach is to also practice evidence-based, non-toxic therapies shown to both reduce your risk of mel. as well as reduce your risk of skin damage.

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Prospective studies show that the risk of melanoma in members of families affected by AMS and FAMMM is significant, with an estimated cumulative risk of 49% in individuals 10 to 50 years of age and 82% in individuals 72 years of age.32

Have you been diagnosed with AMS? Do you have dysplastic nevi? Scroll down the page, post a question or comment and I will reply ASAP.

Thanks,

David Emerson

Cancer Survivor

Cancer Coach

Director PeopleBeatingCancer

Atypical mole syndrome and dysplastic nevi: identification of populations at risk for developing melanoma – review article

“Atypical Mole Syndrome is the most important phenotypic risk factor for developing cutaneous melanoma, a malignancy that accounts for about 80% of deaths from skin cancer. Because the diagnosis of melanoma at an early stage is of great prognostic relevance, the identification of Atypical Mole Syndrome carriers is essential, as well as the creation of recommended preventative measures that must be taken by these patients...”

Although it corresponds to only 4% of all skin cancers, it accounts for 80% of skin cancer deaths.4 Because early detection of the disease is implicit in its cure and only 14% of patients with metastatic disease survive beyond 5 years,46knowledge of factors that increase an individual’s risk for developing melanoma and diagnosis at an early stage of the disease have great prognostic relevance

Clinical Diagnosis

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Clinically, a dysplastic nevus is most often a spotted lesion of 5 mm or more in diameter, with irregular and poorly defined borders and variable shades of brown, and it may present a reddish hue, with bleaching accomplished using vitropressure.18 It often presents a central papule, surrounded by a pigmented macular ring, giving the appearance of a “fried egg”.18 Thus, there is considerable overlap with the ABCDE rule used for clinical diagnosis of melanoma, namely, A: asymmetry, B: irregular borders C: varied colors, D: diameter > 6 mm and E: elevation (simultaneous presentation of macular and papular components) (Figure 1).3,12,18

CONCLUSION

AMS demonstrably increases the risk of developing melanoma, a malignant neoplasm for which incidence have increased significantly in recent decades and for which early diagnosis is of great importance in the prognosis of the disease.4,5

 

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