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Belantamab Mafodotin (Blenrep) for Myeloma
Like all chemotherapy regimens, Belantamab Mafodotin (Blenrep) for Myeloma has risks and benefits, pros and cons. And some serious side effects.
I’m not trying to be dismissive of the benefits of this drug. Paul Sylvester, mentioned here, sounds like his MM was advanced and difficult to treat. I’m just pointing out the serious toxicity of Blenrep.
The video below is saying that if MM patients are aware of ocular toxicity, they can work closely with their oncologist to manage dosing, manage therapy vacations, and then hopefully manage possible problems with their vision.
Belantamab mafodotin in R/R myeloma and methods of reducing ocular toxicity
When I post about MM therapies and their possible side effects, I’ve often felt like I’m being Debbie Downer.
Email me at David.PeopleBeatingCancer@gmail.com to learn about managing your MM with both conventional and non-conventional therapies.
Hang in there,
David Emerson
- MM Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
Belantamab Mafodotin Side Effects
Intravenous route (powder for solution)
Ocular Toxicity. Belantamab mafodotin-blmf caused changes in the corneal epithelium resulting in changes in vision, including severe vision loss and corneal ulcer, and symptoms, such as blurred vision and dry eyes.Conduct ophthalmic exams at baseline, prior to each dose, and promptly for worsening symptoms.
Withhold belantamab mafodotin-blmf until improvement and resume, or permanently discontinue, based on severity.Because of the risk of ocular toxicity, belantamab mafodotin-blmf is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the BLENREP REMS…
Precautions
It is very important that your doctor check your progress closely while you are receiving this medicine to make sure that it is working properly. Blood tests may be needed to check for unwanted effects. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor) before or during treatment.
Receiving this medicine while you are pregnant can harm your unborn baby. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using this medicine to make sure you are not pregnant. Use an effective form of birth control while you are receiving this medicine and for at least 4 months after the last dose to keep from getting pregnant. Males who are taking this medicine, with female partners who can become pregnant, must use effective birth control during and for at least 6 months after the last dose of this medicine. If you think you have become pregnant while receiving the medicine, tell your doctor right away.
This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
Check with your doctor immediately if blurred vision or any other change in vision, difficulty in reading, dry eyes, or eye redness, irritation, or pain occurs during or after treatment. These may be symptoms of a serious eye problem (eg, ocular toxicity). Do not drive or do anything else that could be dangerous until you know how this medicine affects you.,,
This medicine may cause infusion-related reactions, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you start to have a fever, chill or shaking, dizziness, headache, trouble breathing, itching or skin rash, lightheadedness, fainting, or fast, pounding, or uneven heartbeat after receiving this medicine…
Serious side effects
Along with its needed effects, belantamab mafodotin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking belantamab mafodotin:
More common side effects…
Other side effects…
General adverse events
This drug caused serious adverse reactions in 40% of patients. Serious adverse reactions in 3% or more of patients included pneumonia (7%), pyrexia (6%), renal impairment (4%), sepsis (4%), hypercalcemia(4%), and infusion-related reactions (3%). Fatal adverse reactions occurred in 3.2% of patients, including sepsis (1%), cardiac arrest (1%), and lung infection (1%).[Ref]…
Belantamab Mafodotin (Blenrep) for Myeloma Belantamab Mafodotin (Blenrep) for Myeloma