Bile Duct Cancer- Curcumin as Therapy

Share Button

Curcumin induced antiproliferation and apoptosis in bile duct cancer cells with concentration- and time- dependent manners.

Have you been diagnosed with Bile Duct/Biliary Cancer? According to Cancer.netThe 5-year survival rate for people with early-stage extrahepatic bile duct cancer is 30%. If the cancer has spread to the regional lymph nodes, the 5-year survival rate is 24%. If the cancer has spread to a distant part of the body, the 5-year survival rate is 2%…”

I am a long-term survivor of an incurable cancer called multiple myeloma. I have lived in complete remission from my cancer since early 1999. As a cancer coach I encourage cancer patients facing long survival odds to consider evidence-based but non-conventional therapies to manage their cancer.

For more information about curcumin supplementation and cancer therapy or bile duct or pancreatic cancer, scroll down the page, post a question or comment and I will reply ASAP.

thank you,

David Emerson

  • Cancer survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

The gallbladder/gallstone/curcumin question

“... “if I’ve had my gallbladder removed, is it safe for me to take curcumin?” Today I can finally give you an answer. But first let’s take a look at a couple of things…

s you know from my “Side Effects and Warnings” Page (which you will find by scrolling down and looking on the right), curcumin increases the production of bile and also makes the gallbladder contract, which is great if you have no gallbladder problems. But if, for example, you already have gallstones, it’s a bad thing for your gallbladder to contract…In a nutshell, it can make things worse…

That said, if you do NOT have gallstones, curcumin will prevent their formation, which is excellent news for those of us who don’t have ‘em. And, if you suffer from indigestion and/or gas and/or bloating, curcumin can be of much help (again, if you don’t have any gallbladder issues). This morning I came across a 2013 University of Genoa (Italy!!!) study that I haven’t had the time to read in any depth, but it states clearly that curcumin prevents the formation of gallstones: http://goo.gl/Adm4Cs (See paragraph titled: “Choleretic-cholagogue effect.” Interesting information…”

Curcumin induces apoptosis in gallbladder carcinoma cell …

Curcumin induces apoptosis in gallbladder carcinoma cell line GBC-SD cells.…”

Redox modulation and human bile duct cancer inhibition by curcumin.

“The study was to clarify effects of curcumin on cholangiocarcinoma cells, a cancer of the bile duct that refractory to chemotherapeutic drugs…Curcumin induced antiproliferation and apoptosis in KKU-M214 CCA cells with concentration- and time- dependent manners. 

The study suggests that curcumin could be developed into an effective chemoprevention against CCA.”

Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways.

Cholangiocarcinoma (CCA) is a tumor with poor prognosis that is resistant to all currently available treatments.

Examination of… demonstrated that curcumin inhibited proliferation of and induced apoptosis in these biliary cancer cells. Colony-formation assay confirmed the growth-inhibitory effect of curcumin on CCA cells.

Overall, our results indicate that curcumin mediates its antiproliferative and apoptotic effects through activation of multiple cell signaling pathways, and thus, its activity against CCA should be further investigated.”

The Most Bioavailable Curcumin Formulas

“Based on a review of these studies, it is evident that better bioavailability of formulated curcumin (CU) products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism”

A search of the Pubmed database for the word curcumin yields 601 studies spaning health topics from multiple myeloma and colorectal cancer, to chemotherapies that synergizes with CU, to Alzheimer’s Disease, arthritis and more. Based on years of reading studies and personal accounts, I think it is safe to say that CU supplementation is safe and relatively inexpensive.

I have read about myeloma patients taking daily doses of CU from 400 milligrams to 8 grams (1000 milligrams = 1 gram). By almost any measure, CU is a safe, inexpensive wonder drug.

The only challenge is that CU is famously difficult to absorb in the body. In other words, a person has to mix curcumin with some sort of fat (coconut oil, chocolate, etc.) or take a brand of curcumin capsule that is already formulated to be more “bioavailable” in order to derive the full benefit of CU.

The study linked and exerpted below reviews different formulations of CU. The study itself lists the three most bioavailable formulation/brand of CU and I’ve added an excerpt from a further review from Consumerlab.com that lists four additional bioavailable brands of CU.


Recommended Reading:


Curcumin

CU is a bright yellow chemical produced by some plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. It is sold as an herbal supplement, cosmetics ingredient, food flavoring, and food coloring.[1]

Bioavailable curcumin formulations: A review of pharmacokinetic studies in healthy volunteers.

“Curcumin is a widely studied natural compound which has shown tremendous in vitro therapeutic potential. Despite that, the clinical efficacy of the native CU is weak due to its low bioavailability and high metabolism in the gastrointestinal tract. During the last decade, researchers have come up with different formulations with a focus on improving the bioavailability of curcumin. As a result, a significant number of bioavailable curcumin-based formulations were introduced with the varying range of enhanced bioavailability.

The purpose of this review is to collate the published clinical studies of CU products with improved bioavailability over conventional (unformulated) CU. Based on the literature search, 11 curcumin formulations with available human bioavailability and pharmacokinetics data were included in this review. Further, the data on clinical study design, analytical method, pharmacokinetic parameters and other relevant details of each formulation were extracted.

Based on a review of these studies, it is evident that better bioavailability of formulated curcumin products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism. The review hopes to provide a quick reference guide for anyone looking information on these bioavailable curcumin formulations.

Based on the published reports,

exhibited over 100-fold higher bioavailability relative to reference unformulated CU. Suggested mechanisms accounting for improved bioavailability of the formulations and details on the bioanalysis methods are also discussed.”

According to Consumerlab.com:

“Novasol has the highest bioavailability (185 x compared to unforumulated CU), followed by Curcuwin (136 x), Longvida (100 x), Meriva (48 x), BCM-95 (27 x), Curcumin C3 Complex + Bioperene (20 x), and then Theracumin (16 x).”

Leave a Comment:

7 comments
Add Your Reply