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If Curcumin heals GERD will it also heal Barrett’s Esophagus?

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Barrett’s Esophagus is Pre-Cancer. Consider Evidence-based, non-toxic therapies to heal GERD, Barrett’s Esophagus and reduce your risk of Esophageal Cancer

According to research approximately 18.6 million Americans  had symptoms of GERD (gastrointestinal reflux disease) in 2010.  About 10%-15% percent of GERD patients will develop Barrett’s Esophagus (BE). Less than 1% of Barrett’s patients will develop esophageal cancer. A small percentage but a substantial number of people diagnosed diagnosed annually with an aggressive cancer.

I’ve learned that most people will make a reasonable effort to reduce their risk of cancer if:

  1. They have an incentive
  2. They know of evidence-based, inexpensive therapies

 

GERD or Barrett’s Esophagus is your incentive to take steps to reduce your risk of esophageal cancer. Curcumin, one of many non-toxic therapies shown to reduce the risk of esophageal cancer, is inexpensive and proven.

Do you suffer from GERD? BE? EC? Are you interested on safe, non-toxic therapies to reduce your risk of esophageal cancer?

I am a long-term cancer survivor and cancer coach. I take Life Extension Super Bio Curcumin daily. This brand of curcumin is more bioavailable than others and has been tested and approved by consumerlab.com.

Scroll down the page, post a question or comment and I will reply to you ASAP.

thanks,

David Emerson

  • Cancer Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

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Gastroesophageal reflux disease

GERD, also known as acid reflux, is a long-term condition where stomach contents come back up into the esophagus resulting in either symptoms or complications.[4][5] Symptoms include the taste of acid in the back of the mouth, heartburn, bad breath, chest pain, vomiting, breathing problems, and wearing away of the teeth. Complications include esophagitis, esophageal strictures, and Barrett’s esophagus.[4]

Curcumin heals indomethacin-induced gastric ulceration by stimulation of angiogenesis and restitution of collagen fibers via VEGF and MMP-2 mediated signaling.

“We examined the molecular mechanism of curcumin in a preventive and therapeutic model of indomethacin-induced gastric ulceration with regard to angiogenic processes.

RESULTS:

Disrupted blood vessels, reduced collagen matrices, and significant (60%) injury to mucosal cells were observed during ulceration. In addition, ulcerated tissues exhibited decreased matrix metalloproteinase (MMP)-2 and vascular endothelial growth factor (VEGF) expression in blood vessels. Interestingly, curcumin blocked ulceration by induction of collagenization and angiogenesis in gastric tissues via upregulation of MMP-2, membrane type (MT) 1-MMP, VEGF, and transforming growth factor (TGF)-β at protein and messenger ribonucleic acid (mRNA) levels. To examine the angiogenic properties of curcumin, we employed a chorioallantoic membrane model and Matrigel assay. During healing, curcumin promoted collagenization and angiogenesis as well as enhanced MMP-2 activity via positive MT1-MMP regulation and negative tissue inhibitor of metalloproteinase-2 regulation.

INNOVATION:

Our study demonstrates that curcumin-mediated healing is associated with increased MMP-2, TGF-β, and VEGF expression and that it plays a pivotal role as an angiogenic modulator by stimulating vascular sprout formation and collagen fiber restoration in ulcerated tissues.

CONCLUSION:

We conclude that curcumin remodels gastric tissues by restoring the collagen architecture and accelerating angiogenesis.

 

 

Leave a Comment:

8 comments
Claude Dubois says a couple of years ago

I have Barrett’s disease they put me on pantoprazole 40 mg a year ago they check me for cancer they took a biopsi everything came back neg the doctor say it acid reflux how did it but my stomach never feel burning maybe it is silent reflux …is it ok to take cucurmin
Thank need your help

Reply
    David Emerson says a couple of years ago

    Hi Claude-

    I’m not sure what you are asking in your question but I’ll take a stab at a reply. Keep in mind that I am not an M.D. I am a cancer survivor who has learned a lot about cancer from personal experience and research.

    My understanding is that you were diagnosed with Barrett’s Esophagus about a year ago. Your doctor prescribed a proton pump inhibitor because he, your doctor, felt that you needed to calm the acid in your stomach.

    You are confused, however, because you have never felt any “burning” which you believe accompanies acid?

    While I cannot say what your doctor was thinking, I can say that if your biopsy did not indicate esophageal cancer, that is great. Further, you can have barrett’s without burning.

    Lastly, yes, curcumin has been shown to heal GERD and BE to reduce your risk of EC.

    I hope this helps. Thanks.

    David Emerson

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