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C-B-D/T-H-C for Endometrial/Uterine Cancer

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“We observed that at concentrations higher than 5 μM, eCBs and C-B-D induced a significant reduction in cell viability in both Ishikawa and Hec50co cells…”

Dear Cancer Coach: I am post op stage 2 endometrial and uterine cancer, estrogen hormone positive, grade 1. I have read that T-H-C can cause hormonally driven cancers to spread.

I have seen conflicting advice on this. One site recommended 4:1 CBD to thc. Do u agree with this? I may need a coach.

Hi Kathy,

Several things. I am sorry to learn of your endo/uterine cancer. Regarding your question about CBD/THC, my experience, based on the article linked below, is that CBD/THC has anti-endometrial properties. While the study below does not specifically address the issue of “hormonlly driven cancer to spread”, the article does say that C-B-D/T-H-C has:

“Selective targeting of TPRV1 by AEA, CBD, or other stable analogues may be an attractive research area for the treatment of estrogen-dependent endometrial carcinoma.”

As for the specific strain and/or ratio, I think the most important factor (according to studies) is the percentage of cannabinoids IN the CBD oil. In other words, the CBD oil that you reference may have only 1 or 2 percent of cannabinoids in the oil and therefore do very little for you. My understanding is that the CBD oil should have upwards of 20% cannabinoids content.

I have read studies that cite at least some T-H-C as enhancing the anti-cancer activity of C-B-D but some people just don’t like the psychotropic feeling of T-H-C. This is your call.

Lastly, I think it is important to add additional evidence-based, non-conventional therapies to your regimen. Therapies such as nutrition, nutritional supplements, frequent moderate exercise, etc.

Let me know if you have any other questions.

David Emerson

  • Cancer Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:

Cannabinoid-induced cell death in endometrial cancer cells: involvement of TRPV1 receptors in apoptosis.

Among a variety of phytocannabinoids, Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most promising therapeutic compounds. Besides the well-known palliative effects in cancer patients, cannabinoids have been shown to inhibit in vitro growth of tumor cells. Likewise, the major endocannabinoids (eCBs), anandamide (AEA) and 2-arachidonoylglycerol (2-AG), induce tumor cell death.

The purpose of the present study was to characterize cannabinoid elements and evaluate the effect of cannabinoids in endometrial cancer cell viability.

The presence of cannabinoid receptors, transient receptor potential vanilloid 1 (TRPV1), and endocannabinoid-metabolizing enzymes were determined by qRT-PCR and Western blot. We also examined the effects and the underlying mechanisms induced by eCBs and phytocannabinoids in endometrial cancer cell viability. Besides TRPV1, both EC cell lines express all the constituents of the endocannabinoid system.

We observed that at concentrations higher than 5 μM, eCBs and CBD induced a significant reduction in cell viability in both Ishikawa and Hec50co cells, whereas THC did not cause any effect. In Ishikawa cells, contrary to Hec50co, treatment with AEA and CBD resulted in an increase in the levels of activated caspase -3/-7, in cleaved PARP, and in reactive oxygen species generation, confirming that the reduction in cell viability observed in the MTT assay was caused by the activation of the apoptotic pathway. Finally, these effects were dependent on TRPV1 activation and intracellular calcium levels.

These data indicate that cannabinoids modulate endometrial cancer cell death. Selective targeting of TPRV1 by AEA, CBD, or other stable analogues may be an attractive research area for the treatment of estrogen-dependent endometrial carcinoma. Our data further support the evaluation of CBD and CBD-rich extracts for the potential treatment of endometrial cancer, particularly, that has become non-responsive to common therapies.

 

Leave a Comment:

8 comments
Deb Vallus says a couple of years ago

Hello David – I wonder if you work with people like me who have opted out of conventional medical treatments for endometrial cancer… meaning no surgery, chemo, radiation, conventional pharma. I have been using cbd oil and medical cannabis. Plus another completely off-label ‘drug’ that really seems to be helping but that I’m waiting until later to talk about. Thank you & congrats on your own success.

Reply
    David Emerson says a couple of years ago

    Hi Deb-

    Thank you. I work with cancer survivors and caregivers. My job is to research and present information about both conventional and non-conventional therapies. The patient/survivor decides his/her therapy plan.

    It is interesting to read of the growing interest in off-label therapies.

    hang in there,

    David Emerson

    Reply
Laurie Harrison says 4 years ago

How does one know, without an internal exam or biopsy,, that CBD has caused apoptosis of precancerous cells?

Reply
    David Emerson says 4 years ago

    Hi Laurie-
    The short answer is, without an internal exam or biopsy, you can’t know if CBD caused apoptosis of precancerous cells. Studies have documented the ability of a number of non-toxic therapies to kill uterine cancer cells. But you can’t know without diagnostic testing.

    David Emerson

    Reply
David Emerson says 4 years ago

Hi Justyna- I specialize in multiple myeloma. I no longer coach endometrial cancer. To answer your question about CBD dosing, as a non-conventional therapy, the studies of CBD oil talk only about ” a time and dose dependent manner” meaning the more the better.
My point is that your mom should start slow and increase her dosing as she sees fit.
David

Reply
Justyna says 4 years ago

Is there any way I can get a translation of all this to the average person that doesn’t understand such intense medical terms ??

My mother has endometrial cancer and in the spleen… she went through 6 rounds of chemo and in combination was taking high grade CBD and THC…. the cancer in the endometrial area has cleared but it’s still in the spleen… they put her on some clinical trial medication but she reacted very badly to it … and I’m afraid this medication will not be an option for her… I’m trying to understand how THC and CBD works for her in this case

Reply
    David Emerson says 4 years ago

    Hi Justyna,

    I’m sorry for any/all medical jargon. I try to research and write about/symplify the studies but they can still be confusing. The reason why I am a cancer coach is for the reason why you are writing. As a long-term cancer survivor myself, I understand and provide info and expertise.

    For a fee I work with cancer patients and caregivers to understand their conventional therapies (chemo your mom has already had) and will as future non-conventional therapies such as CBD/THC as well as possible chemotherapies.

    I am here if you need me. Hang in there,

    David Emerson

    Cancer Survivor
    Cancer Coach
    Director PBC

    Reply
      Justyna says 4 years ago

      Hello thank you for the response, and where can I find your fee’s

      My mother’s immune system isn’t doing so great and he white blood cell count has been too low for chemo twice now …. she is taking CBD & THC religiously but I’m trying to research if she is taking enough ? She takes it twice a day …. CBD mostly in the morning and 1/2 and 1/2 of CBD and THC at night thru a suppository

      Her diagnoses is called Advanced recurring endometrial cancer … any help would be much appreciated

      Reply
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