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Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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Can Astaxanthin support Myeloma?
Can astaxanthin support myeloma patients and survivors? When I was diagnosed with MM I spent the next 3.5 years undergoing conventional MM therapies such as surgery, chemotherapy and radiation.
Most if not all MM patients undergo lots of toxicity during their MM experience. The challenge is that while these therapies can kill MM, they can also cause lots of damage.
Though I reached complete remission (an alternative cancer therapy called ANP, I developed a series of serious side effects. Chemotherapy-induced cardiomyopathy is one of the most serious of my side effects.
So when I read the study linked below I decided to write a blog post about the many health benefits of astaxanthin.
I want to stress that first and foremost, I try to get as much of the benefits of substances like astaxanthin from the food I eat. But there are many examples of supplements that I take because I just don’t eat enough of the foods that can provide it- think fish oils, curry, red wine… etc.
Astaxanthin : The Health Benefits Review
How can astaxanthin support cancer survivors?
Astaxanthin, a naturally occurring carotenoid with potent antioxidant properties, may support cancer survivors in several ways:
- Reducing Oxidative Stress: Cancer treatments like chemotherapy and radiation often increase oxidative stress in the body. Astaxanthin’s antioxidant capabilities may help reduce this stress, supporting cellular health and recovery.
- Anti-Inflammatory Properties: Chronic inflammation is a concern for cancer survivors, as it can contribute to recurrence or other health issues. Astaxanthin may help reduce inflammation by inhibiting inflammatory pathways.
- Immune System Support: Astaxanthin has been shown to modulate the immune system, potentially improving its ability to fight infections and other challenges post-cancer treatment.
- Skin and Tissue Health: Survivors may experience skin damage or other tissue-related side effects from treatments. Astaxanthin has demonstrated benefits in improving skin elasticity, hydration, and overall health, which might assist in recovery.
- Fatigue Reduction: Astaxanthin has been explored for its role in improving energy metabolism and reducing fatigue, which is a common concern among cancer survivors.
Considerations:
- Individual Health Needs: Cancer survivors should consult healthcare providers before starting any new supplement, including astaxanthin, to ensure it aligns with their specific health circumstances and treatment history.
I’m often asked if nutritional supplements interfere with chemotherapy. Many oncologists discourage their patients from supplementation. However, I’ve read many studies that support cancer patients supplementing.
If you are at all conflicted on the subject I recommend supplementing only when you are not undergoing active therapy.
Email me at David.PeopleBeatingCancer@gmail.com with your questions about MM.
Thank you,
David Emerson
- MM Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
Astaxanthin: Sources, Extraction, Stability, Biological Activities-
“There is currently much interest in biological active compounds derived from natural resources, especially compounds that can efficiently act on molecular targets, which are involved in various diseases…
Astaxanthin, used as a nutritional supplement, antioxidant and anticancer agent, prevents diabetes, cardiovascular diseases, and neurodegenerative disorders, and also stimulates immunization. Astaxanthin products are used for commercial applications in the dosage forms as tablets, capsules, syrups, oils, soft gels, creams, biomass and granulated powders…
Conclusion-The current research data on astaxanthin is encouraging and have resulted from well controlled trials in in vitro and in vivo models. Astaxanthin showed potential effects on various diseases including cancers, hypertension, diabetes, cardiovascular, gastrointestinal, liver, neurodegenerative, and skin diseases..”
Astaxanthin mitigates doxorubicin-induced cardiotoxicity
Background: Doxorubicin (DOX), a widely employed chemotherapeutic agent in cancer treatment, has seen restricted use in recent years owing to its associated cardiotoxicity. Current reports indicate that doxorubicin-induced cardiotoxicity (DIC) is a complex phenomenon involving various modes of cell death.
Astaxanthin (ASX), a natural carotenoid pigment, has garnered significant attention for its numerous health benefits. Recent studies have shown that ASX has a broad and effective cardiovascular protective effect.
Our study aims to investigate the protective effects of ASX against DIC and elucidate its underlying mechanisms. This has substantial practical significance for the clinical application of DOX.
Methods: Bioinformatic analyses were conducted using transcriptomic data from the gene expression omnibus (GEO) database to identify key mechanisms underlying DIC.Network pharmacology was employed to predict the potential pathways and targets through which ASX exerts its effects on DIC. In vitro experiments, following pretreatment with ASX, H9C2 cells were exposed to DOX.
Cell viability, injury and the protein expression levels associated with ferroptosis and autophagy were assessed.In the animal experiments, rats underwent four weeks of gavage treatment with various doses of ASX, followed by intraperitoneal injections of DOX every two days during the final week.
Histological, serum, and protein analyses were conducted to evaluate the effects of ASX on DIC.The bioinformatics analysis revealed that ferroptosis and autophagy are closely associated with the development of DIC. ASX may exert an anti-DIC effect by modulating ferroptosis and autophagy.
The experimental results show that ASX significantly mitigates DOX-induced myocardial tissue damage, inflammatory response, oxidative stress, and damage to H9C2 cells.
Mechanistically, ASX markedly ameliorates levels of ferroptosis and autophagy both in vitro and in vivo.Specifically, ASX upregulates solute carrier family 7 member 11 (SLC7A11) and glutathione peroxidase 4 (GPX4), while downregulating the expression of transferrin receptor 1 (TFRC), ferritin heavy chain (FTH1) and ferritin light chain (FTL). 3
Additionally, ASX enhances the expression of P62 and decreases levels of Beclin1 and microtubule-associated proteins light chain 3 (LC3). Conclusions: Our results indicate that ferroptosis and autophagy are critical factors influencing the occurrence and progression of DOX-induced cardiotoxicity. ASX can alleviate DIC by inhibiting ferroptosis and autophagy.”
Can astaxanthin support myeloma Can astaxanthin support myeloma