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Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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Can Vitamin D Slow Aging?
Can vitamin D slow aging? Yes, according to the research linked below. FYI, my purpose in writing this post is NOT to highlight some anti-aging therapy.
The two reasons for writing this post are:
- Bring attention to yet another health benefit of vitamin D supplementation and
- Try to balance the aging process, already begun by chemotherapy.
While I don’t look to segments on Good Morning America to cover important topics for MM patients, I found this GMA segment to focus on the key issues-
Vitamin D supplements may slow biological aging, new study finds
I am quick to follow the anti-aging properties of vitamin D supplementation, with many other reasons for MM patients to consider supplementation with vitamin D.
- Myeloma, Vitamin D and Gut Health
- Is Vitamin D Important for Myeloma?
- Vitamin D- Myeloma side effect prevention
- Vitamin D, Myeloma Immune Function
- Bone Health- Vitamin D3 as Therapy
- Myeloma, Nerve Pain & Vitamin D3
I am a long-term MM survivor. Email me at David.PeopleBeatingCancer@gmail.com to learn more about managing your MM with both conventional and evidence-based non-conventional therapies.
David Emerson
- MM Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
Vitamin D3 and marine ω-3 fatty acids supplementation and leukocyte telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial
Background
Limited studies suggest that vitamin D or omega 3 fatty acids (n-3 FAs) supplementation may be beneficial for telomere maintenance, however, evidence from large randomized clinical trial is lacking.
Objective
We aimed to determine whether vitamin D or n-3 FAs supplementation reduce leukocyte telomere length (LTL) attrition over time by leveraging the VITamin D and OmegA-3 TriaL (VITAL) trial.
Methods
VITAL is a large, randomized, double-blind, placebo-controlled trial with a 2 x 2 factorial design of vitamin D3 (2,000 IU/day) and marine n-3 FAs (1 g/day) supplements for 5 years among a representative sample of 25,871 US females ≥55 and males ≥50 years of age.
The VITAL Telomere study (NCT04386577) included 1054 participants who were evaluated in person at the Harvard Clinical and Translational Science Center. LTL was determined by the Absolute Human Telomere Length Quantification quantitative Polymerase Chain Reaction (PCR) method at baseline, Year 2, and Year 4. The pre-specified primary outcome measures were changes in LTL between baseline, Year 2 and Year 4. Analyses of intervention effect used mixed-effects linear regression models.
Results
LTL was measured in a total of 2,571 samples from the 1031 participants at baseline, year 2, and year 4. Compared to placebo, vitamin D3 supplementation significantly decreased LTL attrition by 0.14 kilo base pairs (kb) (95%CI: 0.007, 0.27) over 4 years (p = 0.039). Overall trend analysis showed that the vitamin D3 supplementation group had LTLs that were about 0.035 kb higher per year of follow-up compared to placebo group (95%CI: 0.002, 0.07, p=0.037). Marine n-3 FAs supplementation had no significant effect on LTL at either year 2 or year 4.
Conclusion
4-years of supplementation with 2000 IU/day vitamin D3 reduced telomere attrition by 140 bp, suggesting that vitamin D3 daily supplementation with or without n-3 FAs might have a role in counteracting telomere erosion or cell senescence.
Can vitamin D slow aging Can vitamin D slow aging Can vitamin D slow aging