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Cancer Coaching- Does PQQ Promote Breast Cancer?

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“study showed that higher concentrations of PQQ (50-100 μM) could result in 2-5 fold increase in apoptosis-inducing of U937 human promonocytic lymphoma cells through the depletion of cellular glutathione and the increasing of intracellular ROS..”

Dear Cancer Coach- I’m an early breast cancer patient (DCIS) utilizing solely natural treatments right now and am taking Pyrroloquinoline quinone (PQQ) along with Berberine and a host of other supplements. I’ve read some conflicting reports which state PQQ promotes cancer growth. If you can shed any light on this I’d be so grateful. Thanks for any insight you can provide.

Hi BC Survivor-

I am linking the two studies below to demonstrate the pawcity of research into PQQ and breast cancer. Or any type of cancer for that matter.

The idea that antioxidant supplementation, any type of antioxidants, can encourage cancer’s growth is still a topic of heated debate. Dispite the dozens of studies encorporating thousands of patients,  pointing to either

  1. specific antioxidants (PQQ and curcumin for example) being apoptotic (killing) cancers and/or
  2. cancer patients supplementing with both nutritional antioxidants as well as antioxidants in capsule form, living better and longer-

The debate continues.

Keep in mind also, that surviving cancer is about killing the cancer certainly, but it is also about surviving therapies such as chemo and radiation. Your approach, non-toxic therapies, is one approach to minimize dise effects. Another approach can be antioxidant supplementation such as PQQ, shown to protect heart and brain health, both that take a hit with chemotherapy administration.

I believe there are a host of evidence-based, non-toxic breast cancer therapies. If you would like to learn more scroll down the page, post a question or comment and I will reply to you ASAP.

Thank you,

David Emerson

  • Cancer Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading-

Pyrroloquinoline Quinone Induces Cancer Cell Apoptosis via Mitochondrial-Dependent Pathway and Down-Regulating Cellular Bcl-2 Protein Expression

“Discussion- PQQ, as an antioxidant nutrient, has the effects of radioprotection and neuroprotection…

Thus PQQ exhibits strong antioxidant feature 5. Recently, study showed that higher concentrations of PQQ (50-100 μM) could result in 2-5 fold increase in apoptosis-inducing of U937 human promonocytic lymphoma cells through the depletion of cellular glutathione and the increasing of intracellular ROS 9. Other studies also demonstrated that PQQ could regulate cell function of different cells and induce cell apoptosis, directly or indirectly 5, 10, 11. However, there is no study that has investigated the effect of PQQ on directly inducing solid tumor cell apoptosis and the associated mechanisms…”

Study shows antioxidant use may promote spread of cancer

“A team of scientists at the Children’s Research Institute at UT Southwestern (CRI) has made a discovery that suggests cancer cells benefit more from antioxidants than normal cells, raising concerns about the use of dietary antioxidants by patients with cancer. The studies were conducted in specialized mice that had been transplanted with melanoma cells from patients. Prior studies had shown that the metastasis of human melanoma cells in these mice is predictive of their metastasis in patients…

Leave a Comment:

Michael Hope says 3 years ago

Very interesting article about anti oxidants increasing cancer growth. I have helped many people over the years with everything from brain tumours, breast cancer, stomach cancer, multiple myeloma, you name it.

I am lucky enough that some of these people allowed some experimentation on themselves. This is what we found, backed up through blood tests and scans.

While treating people with THC/CBD and a couple of other supplements we found that the anti oxidant increasing the cancer cell growth rate to be a double edged sword to the cancer. The faster it tried to reproduce the more THC/CBD and other supplements became effective. We proved this with 5 people, albeit a small sample, with identical breast cancer (HER2) all virtually at the same size tumours and all very similar blood markers.

PQQ at 20mg twice a day absolutely increased apoptosis, not decreased it. Initially the 3 on PQQ noticed increased palpable tumour size along with an increase in markers. We were initially very worried but the 3 ladies continued on. Around 6 weeks after the taking PQQ all the markers fell off a cliff and tumour size shrunk, so dramatically that the other 2 women who were only on THC/CBD and supplements took up PQQ too. Same time period their marker also fell off the cliff and decreased dramatically.

My friend has Parkisons disease, we have been treating him with our own auto-immune protocol I developed for my own graves disease. Adding 20mg PQQ 2 times a day, the difference was noticeable within a week.

I think some of these studies that are carried out with only one supplement in isolation of other supplements are a complete fraud, this being one of them. PQQ is now one of our staple supplements when treating cancer, heart disease and auto immune diseases.

    David Emerson says 3 years ago

    Hi Michael,

    I replied to your post directly via email. Thanks.

    David Emerson

    Sam says 3 years ago

    Hi Michael

    Have you seen PQQ supplementation work for metastatic HER2-positive breast cancer?

    Kind regards


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