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Cancer Coaching- Does PQQ Promote Breast Cancer?

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“study showed that higher concentrations of PQQ (50-100 μM) could result in 2-5 fold increase in apoptosis-inducing of U937 human promonocytic lymphoma cells through the depletion of cellular glutathione and the increasing of intracellular ROS..”

Dear Cancer Coach- I’m an early breast cancer patient (DCIS) utilizing solely natural treatments right now and am taking Pyrroloquinoline quinone (PQQ) along with Berberine and a host of other supplements. I’ve read some conflicting reports which state PQQ promotes cancer growth. If you can shed any light on this I’d be so grateful. Thanks for any insight you can provide.


Hi BC Survivor-

I am linking the two studies below to demonstrate the pawcity of research into PQQ and breast cancer. Or any type of cancer for that matter.

The idea that antioxidant supplementation, any type of antioxidants, can encourage cancer’s growth is still a topic of heated debate. Dispite the dozens of studies encorporating thousands of patients,  pointing to either

  1. specific antioxidants (PQQ and curcumin for example) being apoptotic (killing) cancers and/or
  2. cancer patients supplementing with both nutritional antioxidants as well as antioxidants in capsule form, living better and longer-

The debate continues.

Keep in mind also, that surviving cancer is about killing the cancer certainly, but it is also about surviving therapies such as chemo and radiation. Your approach, non-toxic therapies, is one approach to minimize dise effects. Another approach can be antioxidant supplementation such as PQQ, shown to protect heart and brain health, both that take a hit with chemotherapy administration.

I believe there are a host of evidence-based, non-toxic breast cancer therapies. If you would like to learn more scroll down the page, post a question or comment and I will reply to you ASAP.

Thank you,

David Emerson

  • Cancer Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading-


Pyrroloquinoline Quinone Induces Cancer Cell Apoptosis via Mitochondrial-Dependent Pathway and Down-Regulating Cellular Bcl-2 Protein Expression

“Discussion- PQQ, as an antioxidant nutrient, has the effects of radioprotection and neuroprotection…

Thus PQQ exhibits strong antioxidant feature 5. Recently, study showed that higher concentrations of PQQ (50-100 μM) could result in 2-5 fold increase in apoptosis-inducing of U937 human promonocytic lymphoma cells through the depletion of cellular glutathione and the increasing of intracellular ROS 9. Other studies also demonstrated that PQQ could regulate cell function of different cells and induce cell apoptosis, directly or indirectly 5, 10, 11. However, there is no study that has investigated the effect of PQQ on directly inducing solid tumor cell apoptosis and the associated mechanisms…”

Study shows antioxidant use may promote spread of cancer

“A team of scientists at the Children’s Research Institute at UT Southwestern (CRI) has made a discovery that suggests cancer cells benefit more from antioxidants than normal cells, raising concerns about the use of dietary antioxidants by patients with cancer. The studies were conducted in specialized mice that had been transplanted with melanoma cells from patients. Prior studies had shown that the metastasis of human melanoma cells in these mice is predictive of their metastasis in patients…

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