What I wish I knew about Multiple Myeloma treatments 25 years later...

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Cannabis as Multiple Myeloma Therapy-

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Cannabinoids have a very selective antitumor effect against MM cells… In vivo studies confirmed the efficacy of these agents in the treatment of MM…”

The fall of 2013 marks the beginning of PeopleBeatingCancer’s research into cannabis (CAN), CBD, cannabinoids as a therapy for multiple myeloma (MM) – for pain, nausea and as a therapy to kill MM itself.

 My initial research indicates that

  • CAN is a legitimate therapy for pain
  • CAN is a legitimate therapy for nausea
  • CAN is a legitimite integrative therapy when combined with certain chemotherapy regimens
  • CAN may be a legitimate therapy for your cancer depending on your type and stage

Some of the challenges faced by cancer patients currently is to determine if CAN may “work” on their cancer and, if so, what strain of cannabis or what strength, dose and ratio of cannabinoids and THC.

I am a long-term multiple myeloma survivor and MM cancer coach. To learn more about how medical marijuana may help you with your cancer, scroll down the page, post a question or a comment and I will reply to you ASAP.

Ed.Note- update as of 1/18- CAN for medical purposes has been legalized in many U.S. states and Canada though CAN has not been well-studied. At least not enough in my mind due to the desire of MM patients, survivors and caregivers to find therapies that can treat their pain, nausea, etc. and possibly act directly on their cancer.

thank you,

David Emerson

  • Multiple Myeloma survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer

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Some definitions-

Cannabidiol (CBD) is one of at least 85 cannabinoids found in cannabis.[2] It is a major constituent of the plant, second to THC, and represents up to 40% in its extracts.[3] Compared with THC, cannabidiol is less psychoactive, and is considered to have a wider scope of medical applications than THC,[4] including to epilepsy,[5] multiple sclerosis spasms,[6] anxiety disorders, bipolar disorder,[4] schizophrenia,[7] nausea, convulsion and inflammation, as well as inhibiting cancer cell growth.

Cannabigerol (CBG)  is a non-psychoactive cannabinoid found in the Cannabis genus of plants. Cannabigerol is found in higher concentrations in hemp rather than in varieties of Cannabis cultivated for high THC content and their corresponding psychoactive properties.

Cannabivarin, also known as cannabivarol or CBV, is a non-psychoactive cannabinoid found in minor amounts in the hemp plant Cannabis sativa

Hemp oil or hempseed oil is obtained by pressing hemp seeds. Cold pressed, unrefined hemp oil is dark to clear light green in color, with a pleasant nutty flavour. The darker the color, the grassier the flavour. Refined hempseed oil is clear and colorless, with little flavor and lacks natural vitamins and antioxidants. Refined hempseed oil is primarily used in body care products. Industrial hempseed oil is used in lubricants, paints, inks, fuel, and plastics-

Medical cannabis refers to the parts of the herb cannabis used as a form of medicine or herbal therapy, or to synthetic forms of specific cannabinoids such as THC (delta-9-tetrahydrocannabinol) as a form of medicine. The Cannabis plant has been used as a medicine over an extensive period of time.[1] Cannabis is one of the 50 “fundamental” herbs of traditional Chinese medicine,[2] and is prescribed for a broad range of indications.

Cannabinoids As Antimyeloma Agents: a New Approach for the Treatment of Multiple Myeloma

“CONCLUSIONS: Cannabinoids have a very selective antitumor effect against MM cells. This effect involves activation of apoptosis processes and alterations in the composition of membrane sphingolipids (ceramides). In vivo studies confirmed the efficacy of these agents in the treatment of MM…”

Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration.

“Herein, we also found that the CBD and THC combination is able to reduce expression of the β5i subunit as well as to act in synergy with CFZ to increase MM cell death and inhibits cell migration. In summary, these results proved that this combination exerts strong anti-myeloma activities.”

Prospective analysis of safety and efficacy of medical cannabis in large unselected population of patients with cancer

“Background-Cancer is a major public health problem as the leading cause of death. Palliative treatment aimed to alleviate pain and nausea in patients with advanced disease is a cornerstone of oncology. In 2007, the Israeli Ministry of Health began providing approvals for medical cannabis for the palliation of cancer symptoms. The aim of this study is to characterize the epidemiology of cancer patients receiving medical cannabis treatment and describe the safety and efficacy of this therapy…

Conclusions-CAN as a palliative treatment for cancer patients seems to be well-tolerated, effective and safe option to help patients cope with the malignancy related symptoms.”

Non-Hallucinogenic Cannabinoids Are Effective Anti-Cancer Drugs

“New research has shown that the non-hallucinogenic components of CAN could act as effective anti-cancer agents. The anti-cancer properties of tetrahydrocannabinol (THC), the primary hallucinogenic component of CAN, has been recognised for many years, but research into similar cannabis-derived compounds, known as cannabinoids, has been limited…

Of six cannabinoids studied, each demonstrated anti-cancer properties as effective as those seen in THC. Importantly, they had an increased effect on cancer cells when combined with each other…”Used in combination with existing treatment, we could discover some highly effective strategies for tackling cancer…

The study examined two forms of cannabidiol (CBD), two forms of cannabigerol (CBG) and two forms of cannabigevarin (CBGV). These represent the most common cannabinoids found in the cannabis plant apart from THC.”

Active Component Of Marijuana Has Anti-Cancer Effects, Study Suggests

“…Consistent with the in vitro data, administration of THC to mice with human tumors decreased tumor growth and induced the tumor cells to undergo autophagy. As analysis of tumors from two patients with recurrent glioblastoma multiforme (a highly aggressive brain tumor) receiving intracranial THC administration showed signs of autophagy, the authors suggest that cannabinoid administration may provide a new approach to targeting human cancers.

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

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