Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
Click the orange button to the right to learn more about what you can start doing today.
Can CBD (cannabidiol) ameliorate heart damage? Specifically, can cannabidiol prevent the chemotherapy-induced cardiomyopathy that doxorubicin (adriamycin) can cause?
I was diagnosed with multiple myeloma in early 1994. I didn’t know it at the time but I was prescribed 5 chemotherapy regimens that are known to be cardiotoxic.
Fully 15 years after my conventional cancer therapies, I developed chemotherapy-induced cardiomyopathy. I wish I knew then what I know now…
What are some other non-conventional therapies to protect against chemo-induced heart damage?
Don’t be surprised if your oncologist does not suggest any of the therapies listed above if you are to undergo one or more cardiotoxic chemo regimens. Everything listed above (as well as CBD) is consider non-conventional meaning, not approved by the FDA.
Email me at David.PeopleBeatingCancer@gmail.com with questions about your MM or questions about chemotherapy-induced cardiomyopathy.
Background:
Doxorubicin (DOX) is a chemotherapeutic agent widely used for cancer treatment and has non-negligible cardiotoxicity. Some previous studies have reported that cannabidiol (CBD) has cardioprotective effects. In this study, we evaluated the protective effects of CBD against DOX-induced cardiomyocyte injury, and explored the downstream molecular mechanism.
Methods and Materials: GSE193861, containing healthy myocardial tissues and myocardial tissues with DOX-induced injury, was analyzed to screen for the involved proteins and pathways. Molecular docking was performed to identify candidate drugs.
After H9c2 cells were treated with DOX and CBD, their viability, oxidative stress, and apoptosis were assessed. After YAP depletion, the role of the Hippo pathway in CBD function was investigated.
C57BL/6 mice were treated with DOX to establish an in vivo model, and CBD and verteporfin (VP) were used to treat the mice. Histological analyses and immunofluorescence were used to evaluate myocardial tissue injury, and apoptosis and oxidative stress of the myocardial tissues were also analyzed. Western blotting was used to investigate the regulatory effects of CBD on the Hippo and apoptosis-related pathways.
Results: Bioinformatic analysis suggested that the Hippo pathway was a crucial pathway involved in DOX-induced myocardial injury. Molecular docking showed that CBD targeted multiple regulators of the Hippo pathway. CBD showed cardioprotective effects against DOX-induced myocardial injury both in vitro and in vivo and regulated Hippo pathway activity in cardiomyocytes. After inactivation of the Hippo pathway by YAP knockdown or VP intervention, the protective effects of CBD were reversed.
Conclusion: For the first time, we revealed that CBD is likely to reduce DOX-induced myocardial injury by regulating the Hippo signaling pathway.
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