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CBD vs. Hemp Oil as Myeloma Therapy- What’s the Diff?

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Hemp oil is not the same as cannabidiol (CBD) oilHemp seed oil comes from the small seeds of the Cannabis sativa plant.”

Hi David. Hi I would really like more information on hemp oil (HO). As far as multiple myeloma is concerned, what is the difference between CBD oil and hemp oil? Joan

Hi Joan,
I want to be sure I understand your question. I am assuming that you are asking about both hemp (H) and hemp seed (HS) and CBD oil all from the standpoint of
  • therapy for multiple myeloma,
  • complementary therapy for MM as well as
  • an integrative MM therapy.
The posts I have written about CBD oil and published on PeopleBeatingCancer.org have all been based on cannabidiol aka full spectrum CBD oil.
HO and hempseed oil, is based on oil from hempseed (pictured to the left) I will link and excerpt from an analysis below.
I think the two articles do a good job of communicating the separate issues.
H and hemp seed is beneficial, nutritionally speaking. However, it is not the same as CBD oil from a MM standpoint. The key difference, at least as MM is concerned, is the issue of full-spectrum cannabinoids and the percentage of THC.
As the bottom linked study explains, cannabinoids enhance or synergize with MM chemotherapy regimens
  • Velcade (bortezomib)
  • Kyprolis (Carfilzomib)
thereby increasing the efficacy of these regimens. H and HO do not. Further, cannabinoids can reduce bone pain while they enhance bone healing. 
All to say it is in the interests of the MM patient to find the oil with the highest percentage of cannabinoids.
The top article linked below does a good job of distinguishing between:
  • Hemp oil
  • CBD oil
As far as the limited research is concerned,  Hemp Seed oil offers nutritional benefits and offers topical benefits only. It is the benefits of cannabinoids, the benefits of CBD oil as a complementary, integrative and non-conventional MM therapy that is of interest of us MM patients and survivors.
Lastly, the top article linked below does talk about “full-spectrum HO.” The article does list health benefits that come from full-spectrum HO however the article admits that more study is needed.
All of the content on PBC that I’ve written about CBD oil and MM, is based on studies of cannabinoids and multiple myeloma and not hemp or hemp seed oil.
Let me know if you have any questions Joanne,
David Emerson
  • MM Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading-

Hemp oil benefits list

HO can refer to a full-spectrum oil from the Cannabis sativa plant or hemp seed oil, which is oil that comes from just the seeds of the hemp plant
There is very little risk of intoxication from hemp oil as all forms of hemp oil come from food-grain strains of hemp. The authors of a study in the journal Cannabis and Cannabinoid Research note that food-grain strains of hemp must contain less than 0.3 percent tetrahydrocannabinol (THC). THC is the compound that causes the so-called “high” of marijuana
  • HO is not the same as cannabidiol (CBD) oil. The production of CBD oil uses the stalks, leaves, and flowers of the hemp plant, which contain a higher concentration of CBD, another potentially beneficial compound in the plant.
  • H seed oil comes from the small seeds of the Cannabis sativa plant. The seeds do not contain the same levels of compounds as the plant itself, but they still have a rich profile of nutrients, fatty acids, and useful bioactive compounds.

What are the health benefits of hemp?

H is a plant grown in the northern hemisphere that takes about 3-4 months to mature. H seeds can be consumed or used to produce a variety of food products including h milk, h oil, h cheese substitutes and hemp-based protein powder.

Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration

“Several studies showed a potential anti-tumor role for cannabinoids, by modulating cell signaling pathways involved in cancer cell proliferation, chemo-resistance and migration.

Cannabidiol (CBD) was previously noted in multiple myeloma (MM), both alone and in synergy with the proteasome inhibitor bortezomib, to induce cell death.

In the current study, we evaluated the effects of THC alone and in combination with CBD in MM cell lines. We found that CBD and THC, mainly in combination, were able to reduce cell viability by inducing autophagic-dependent necrosis…

Herein, we also found that the CBD and THC combination is able to reduce expression of the β5i subunit as well as to act in synergy with CFZ to increase MM cell death and inhibits cell migration. In summary, these results proved that this combination exerts strong anti-myeloma activities…”


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