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Cervical Cancer Complementary/Integrative Therapies-

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Cervical Cancer Patients Must Think Outside the Box to Reach Long-Term Remission while Minimizing Collateral Damage aka Side Effects

A cancer diagnosis is one of the most difficult life experiences you will ever face. The world of cancer therapy is confusing at best, frustrating at worst. Though it may be difficult to see beyond what your oncologist calls your “induction therapy” (initial therapy), I strongly encourage you to look at the bigger picture.

I am a long-term cancer survivor and cancer coach. I have remained in complete remission from my incurable cancer since 1999 by living an evidence-based, non-toxic, anti-cancer lifestyle through nutrition, supplementation, bone health, lifestyle and mind-body therapies.

Image result for photo of strong woman

By bigger picture I mean that you must look at both killing your cancer as well as minimizing side effects that can damage your body in the short, long-term and perhaps late stages.

The studies linked and excerpted below talk about cervical cancer therapies that can both enhance conventional chemotherapy while minimizing toxicity. If you can get an honest opinion from your oncologist, he/she will tell you than a single agent such as cisplatin is both toxic and limited in its efficacy. Utilizing evidence-based therapies to attack your cancer is smart. Especially if the therapies are relatively inexpensive and have few if any side effects of their own.

Do you have cervical cancer? Are you living with short, long-term and late stage side effects?

For more information about other non-toxic, evidence-based therapies to support your cancer management efforts, scroll down the page, post a question or comment and I will reply ASAP.

Thank you,

David Emerson

  • Long-term cancer survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

Vitamin D in gynecological diseases

“Background: Most reproductive system studies suggest the protective effects of vitamin D, but vitamin D deficiency and insufficiency are growing global health issues. The present study investigates the association between vitamin Ddeficiency/insufficiency and gynecologic diseases to identify illness risks at different serum vitamin D levels in Taiwan…

Conclusion:  Associations were found between vitamin D deficiency and endometriosis, uterine myoma, dysmenorrhea, abnormal Pap smear results, and high-risk HPV infection of the cervix. Therefore, vitamin D supplements may present a cost-effective benefit for the prevention and treatment of gynecologic diseases, and thus reduction of healthcare expenditures.

TQ shows synergistic and/or potentiating anticancer effects when combined with clinically used chemotherapeutic agents...”

The bioactive natural products (plant secondary metabolites) are widely known to possess therapeutic value for the prevention and treatment of various chronic diseases including cancer. Thymoquinone (2-methyl-5-isopropyl-1,4-benzoquinone; TQ), a monoterpene present in black cumin seeds, exhibits pleiotropic pharmacological activities including antioxidant, anti-inflammatory, antidiabetic and antitumor effects.

TQ inhibits experimental carcinogenesis in a wide range of animal models and has been shown to arrest the growth of various cancer cells in culture as well as xenograft tumors in vivo.

The mechanistic basis of anticancer effects of TQ includes the inhibition of carcinogen metabolizing enzyme activity and oxidative damage of cellular macromolecules, attenuation of inflammation, induction of cell cycle arrest and apoptosis in tumor cells, blockade of tumor angiogenesis, and suppression of migration, invasion and metastasis of cancer cells.

TQ shows synergistic and/or potentiating anticancer effects when combined with clinically used chemotherapeutic agents. At the molecular level, TQ targets various components of intracellular signaling pathways, particularly a variety of upstream kinases and transcription factors, which are aberrantly activated during the course of tumorigenesis.

Curcumin, cervical and ovarian cancers-

Curcumin supplementation has shown anti-cancer action in breast, prostate, pancreatic, multiple myeloma and other cancers. The studies below cite the ability of curcumin to both kill both ovarian and cervical cancer cells while enhancing the efficacy of certain chemotherapies….”

Resveratrol inhibits the progression of cervical cancer by suppressing the transcription and expression of HPV E6 and E7 genes

“Resveratrol is a representative polyphenol of diet‑derived putative cancer chemopreventive agents, which have attracted increasing interest in the cancer chemoprevention community.

The inhibition of the action of human papillomavirus (HPV) E6 and E7 has been considered a key approach for cervical cancer therapy. Resveratrol has been shown to induce the apoptosis, and reduce both the viability and mitotic index of a number of cancer cell lines, including human cervical cancer cells.

In the present study, it was confirmed that resveratrol inhibited the HPV E6 mRNA, HPV E6 protein and phosphorylated retinoblastoma protein (p‑pRb1) levels, and increased the p53 protein levels in HeLa and Ca Ski cells, as well as in subcutaneous tumor tissue grown from HeLa cells.

On the whole, the present study demonstrates that resveratrol inhibits cervical cancer development by suppressing the transcription and translation of E6 and E7, and also by promoting the apoptosis and G1/S phase transition arrest. These findings may provide the basis for the development of resveratrol as a candidate for cervical cancer therapy…”

Apoptotic activities of thymoquinone, an active ingredient of black seed (Nigella sativa), in cervical cancer cell lines.

“Thymoquinone (TQ) is the main constituent of black seed (Nigella sativa, spp) essential oil which shows promising in vitro and in vivo anti-neoplastic activities in different tumor cell lines.

However, to date there are only a few reports regarding the apoptotic effects of TQ on cervical cancer cells. Here, we report that TQ stimulated distinct apoptotic pathways in two human cervical cell lines, Siha and C33A. TQ markedly induced apoptosis as demonstrated by cell cycle analysis in both cell lines.

Moreover, quantitative PCR revealed that TQ induced apoptosis in Siha cells through p53-dependent pathway as shown by elevated level of p53-mediated apoptosis target genes, whereas apoptosis in C33A cells was mainly associated with the activation of caspase-3…

These results support previous findings on TQ as a potential therapeutic agent for human cervical cancer.”

Thymoquinone from Nigella sativa was more potent than cisplatin in eliminating of SiHa cells via apoptosis with down-regulation of Bcl-2 protein.

Thymoquinone (TQ), the active constituent of Nigella sativa or black cumin exhibited cytotoxic effects in several cancer cell lines. In this study, the cytotoxicity of TQ in human cervical squamous carcinoma cells (SiHa) was investigated. TQ was cytotoxic towards SiHa cells…

TQ was more cytotoxic towards SiHa cells compared to cisplatin. Interestingly, TQ was less cytotoxic towards the normal cells (3T3-L1 and Vero)...

In conclusion, thymoquinone from N. sativa was more potent than cisplatin in elimination of SiHa cells via apoptosis with down-regulation of Bcl-2 protein.

 

Leave a Comment:

2 comments
Maluko says 5 years ago

I have been diagnosed with cells on my cervix that could lead to cancer.i don’t want to do surgery. I read about turmeric and information says it can remove the cells.i have no child and this scares me.please I need mor information on how I can stop this cancer . Please

Reply
    David Emerson says 5 years ago

    Hi Mauko-

    I am sorry to read of your pre-cervical cancer diagnosis. You are correct that your condition can lead to cancer but your condition is currently not cancer. You are correct that there are several supplements/antioxidants such as curcumin that can reduce your risks of cervical cancer. If you don’t mind I would like to ask a couple of question to understand your situation more fully.

    1) You said that you don’t want surgery. Are you interested in learning about other therapies such as cryotherapy?

    2) You said that you “have no child.” Does this mean that you plan to have children in the future?

    3) When you were diagnosed did anyone mention the term “CIN?” If so, do you know if you are CIN 1,2 or 3?

    I am not trying to sound nosey. I’m just trying to get a complete picture of your thinking.

    Let me know. I will organize my recommendations accordingly.

    Thanks

    David Emerson
    Cancer Survivor
    Cancer Coach

    Classification And Screening For Cervical Dysplasia

    Cervical dysplasia is commonly referred to as cervical intraepithelial neoplasia (CIN). It is often classified by the degree of penetration of abnormal cells into the tissue lining (epithelium):

    CIN I describes the involvement of the basal third of the epithelium.
    CIN II involves the basal two thirds of the epithelium.
    CIN III involves more than two thirds of the epithelium.

    Reply
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