“These studies uncovered actionable mutations in multiple myeloma, and coupled with explosion of various pathways and targeted inhibitors there is a growing optimism to hope for mutation specific adapted treatment strategies becoming reality in the near future (cure?)…”
I try not to use the word “cure” when I’m writing about multiple myeloma (MM). But I can come up with no other outcome for my MM experience. I remain completely MM free and I rely exclusively on evidence-based non-conventional therapies… I believe my multiple myeloma therapies have changed my genetic expression…
Conventional oncology studies chemotherapy and how it affects MM. That’s what they do. The top study below talks about changing MM genetic expression with chemotherapy.
I am a long-term multiple myeloma survivor and MM cancer coach. I have remained in complete remission from my “incurable” cancer since 1999 and I was originally diagnosed in 1994.
Conventional chemotherapy did little to treat my MM. In other words, “killing” my MM cells didn’t work for me. But since 1997, I have undergone a host of therapies all that could have changed how my MM genes expressed themselves aka epigenetics.
The GEMINAL study showed that intensive lifestyle changes could alter the genetic expression of prostate cancer patients.
I have to be honest and admit that I can’t prove that my evidence-based, anti-MM nutrition, supplementation, bone health, lifestyle and mind-body therapies actually changed my genetic expression. I did not undergo genetic testing when I was first diagnosed. But as the studies linked and excerpted below explain, supplementation, nutrition and lifestyle can change gene expression. I can prove that all of the non-toxic therapies that I pursue daily are evidence-based and are cytotoxic to MM.
And I have had MM since 1994 and I have been in complete remission since early 1999. So what else could be the reason for what can only be called a cure of my multiple myeloma?
Have you been diagnosed with cancer? What type? What stage? If you would like to learn more about cancer coaching please scroll down the page to post a question or a comment and I will reply ASAP.
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David Emerson
- MM Survivor
- MM Coach
- Director PeopleBeatingCancer
Recommended Reading:
“Moving further into personalized treatment decision making, this mutational profiling may guide therapeutic choice in the future with ever increasing number of available antimyeloma agents or nonmyeloma specific but pathway specific drugs.
In a study of 133 patients with relapsed myeloma treated with single-agent bortezomib, a targeted sequencing of a panel of 41 known oncogenes and tumor suppressor genes was performed [56]. Mutually exclusive mutations of BRAF and RAS were seen in closer to a half of patients and mutations of NRAS (but not KRAS) were associated with lower response rate to bortezomib [56].
On the other hand, mutations in IRF4 which are believed to be the downstream of immunomodulatory drug target of cereblon seem to be associated with better survival [55].
These studies uncovered actionable mutations in multiple myeloma, and coupled with explosion of various pathways and targeted inhibitors there is a growing optimism to hope for mutation specific adapted treatment strategies becoming reality in the near future…”
“A single cancer cell may harbor dozens or even hundreds of mutant genes. Some of those genes instruct the cell to grow abnormally large, others tell it to divide repeatedly or to detach itself and roam the body looking for a new home…
What if you could shut off one, two or even a dozen of those genes, all at once? Some scientists believe that they will soon be able to do just that through RNA interference, a natural process that happens within cells…
“It (siRNA-short interfering RNA) offers the potential to turn off essentially any gene in a cell,”That means scientists can try to shut off the genes that cause cancer cells to go haywire, growing out of control and breaking free from their usual constraints to travel through the body to start new tumors…”
“Conclusion- Experimental evidence accumulated in the recent years clearly supports the idea that dietary nutraceuticals such as curcumin have great potential as epigenetic agents. Unlike genetic changes, epigenetic changes can be modified by the environment, diet, or pharmacological intervention. This characteristic has increased enthusiasm for developing therapeutic strategies by targeting the various epigenetic factors, such as HDAC, HAT, DNMTs, and miRNAs, by dietary polyphenols such as curcumin (Fig. )…”
