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Chemo Ages BC patients 10-15 years?!?!

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We have shown that cytotoxic chemotherapy potently induces the expression of markers of cellular senescence in the hematologic compartment in vivo,

Chemotherapy ages us.  It is a good feeling when researchers confirm something that you have suspected about chemotherapy. Full disclosure- I am not a breast cancer survivor. I am a multiple myeloma survivor. I had high-dose chemotherapy during an autologous stem cell transplant.

I feel like my aggressive chemo, radiation, etc. aged me at least the 15  years cited below.

Image result for image of cellular senescence

Is there any way, any therapy to delay the loss of organ function in cancer survivors who have undergone chemotherapy? My experience over the past 20 plus years is that yes, organ function can be managed.

No I’m not talking about “anti-aging” therapies although you can look at many of the non-toxic therapies that I am talking about as slowing the aging process.Simply put, you will live longer, on average, by pursuing these therapies.

I’m talking about the previous blog I wrote about preventing cataracts. Or I’m talking about the blog I wrote about supplementation to reduce my chronic blood clot. The same blood clot that was caused by my chemotherapy…

The good news is that there are therapies that work integratively to either reduce the toxicity of conventional breast cancer chemotherapy or enhance the efficacy of conventional chemotherapies.

Reducing inflammation ages you more slowly.

In addition to being a cancer survivor I am also a cancer coach. To learn more about non-toxic, non-conventional breast cancer therapies, scroll down the page, post a question or comment and I will reply ASAP.

Thank you,

David Emerson

  • Cancer Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:


Adjuvant chemotherapy increases markers of molecular aging in blood of breast cancer survivors

“Adjuvant chemotherapy for breast cancer is ‘gerontogenic,’ accelerating the pace of physiologic aging, according to a new study. The authors conclude, “We have shown that cytotoxic chemotherapy potently induces the expression of markers of cellular senescence in the hematologic compartment in vivo, comparable with the effects of 10 to 15 years of chronologic aging in independent cohorts of healthy donors.”

10 Things Your Doctor Won’t Tell You About Breast Cancer Treatment

  1. You may experience neutropenia, a serious and potentially life-threatening side effect of chemotherapy.
  2. Side effects of treatment may linger longer than you expect.
  3. Tests are now available to see if you might benefit from chemotherapy.
  4. Advice might be anecdotal, not based on evidence.
  5. Most cancer patients do not participate in clinical trials.
  6. Chemo brain is real. Chemo ages you.
  7. Get a second opinion.
  8. Complementary or alternative treatment may help.
  9. Surviving cancer brings a new set of challenges.
  10. Beware of the ‘hidden’ costs of your treatment.

Younger Skin Through Exercise

“Exercise not only appears to keep skin younger, it may also even reverse skin aging in people who start exercising late in life, according to surprising new research…”

Chemotherapy-induced senescence, an adaptive mechanism driving resistance and tumor heterogeneity

“Senescence is activated in response to chemotherapy to prevent the propagation of cancer cells. In transformed cells, recent studies have shown that this response is not always definitive and that persistent populations can use senescence as an adaptive pathway to restart proliferation and become more aggressive.

Here we discuss the results showing that an incomplete and heterogeneous senescence response plays a key role in chemotherapy resistance. Surviving to successive chemotherapy regimens, chronically existing senescent cells can create a survival niche through paracrine cooperations with neighboring cells. This favors chemotherapy escape of premalignant clones but might also allow the survival of adjacent clones presenting a lower fitness.

A better characterization of senescence heterogeneity in transformed cells is therefore necessary. This will help us to understand this incomplete response to therapy and how it could generate clones with increased tumor capacity leading to disease relapse.”

Leave a Comment:

9 comments
Inflammation- Brain, Skin, Heart, Cancer... - PeopleBeatingCancer says 6 months ago

[…] Chemotherapy Ages Breast Cancer Patients 10-15 years?!?! […]

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Surviving Multiple Myeloma- Side Effects, Aging and Skin Care - PeopleBeatingCancer says 3 years ago

[…] 1994. I have weathered all forms of cancer therapy- conventional, integrative and alternative. I’m here to tell you that aggressive toxic chemotherapy and radiation ages you…at least …. The side effects of toxic therapies are hard on your […]

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Integrative Therapies for Active Surveillance Prostate Cancer says 3 years ago

[…] Chemotherapy Ages Breast Cancer Patients 10-15 years?!?! […]

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The Side Effects of Surviving Multiple Myeloma Require Skin Care - PeopleBeatingCancer says 3 years ago

[…] survivor who has weathered all forms of cancer therapy- conventional, integrative and alternative. I’m here to tell you that aggressive toxic chemotherapy and radiation ages you…at least …. The side effects of toxic therapies are hard on your […]

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Elderly Patients With Multiple Myeloma - PeopleBeatingCancer says 6 years ago

[…] Chemotherapy is toxic. Most everyone undergoing chemo or radiation feels awful having the effect of aging the patient- […]

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Managing Chemo Side Effects With Style - PeopleBeatingCancer says 7 years ago

[…] Chemo ages breast cancer patients 10-15 years?!?! […]

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Prevent skin cancer naturally - PeopleBeatingCancer says 7 years ago

[…] say that chemotherapy ages you by 10-15 years. As the study below explains,  green tea is “enhancing DNA repair” so maybe my skin is […]

Reply
    DURATIUS MOHULATSI says a couple of years ago

    Can I benefit from drinking green tea , had chemotherapy for breast cancer 12 years ago

    Reply
      David Emerson says a couple of years ago

      Hi DM-

      I am sorry to read of your BC diagnosis 12 years ago. Yes, according to research there are a number of non-toxic therapies shown to reduce the risk both of a first BC diagnosis or reducing the risk of a BC relapse.

      David Emerson

      Reply
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