Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
Click the orange button to the right to learn more about what you can start doing today.
This his the first post I have written that talks about CIPN therapy before velcade, not CIPN therapy shown to help CIPN once it starts. Because the FDA approved induction therapy is Velcade, Revlimid and dexamethasone (VRd), virtually all NDMM patients will undergo velcade aka bortezomib.
Chemotherapy-induced peripheral neuropathy is one of the most prevalent and certainly most painful of all MM side effects What’s worse, there are few effective therapies to manage this potentially debilitating side effect.
Let me be clear. There is no guarantee that NDMM patients will develop the side effect called CIPN. My point is that a substantial percentage of NDMM patients develop extremely painful CIPN and I research shows that all NDMM patients will benefit from exercise before they begin active therapy.
If you are a newly diagnosed MM patient, please begin pre-habilitation and include either/or neuromuscular training or whole-body vibration that is to say CIPN therapy before velcade.
If you are a NDMM patient interested in learning more about evidence-based conventional and non-conventional MM therapies email me at David.PeopleBeatingCancer@gmail.com
Thank you,
David Emerson
“Main Outcomes and Measures The primary end point was the incidence of CIPN. Secondary end points included subjective neuropathy symptoms, balance control, physical activity levels, quality of life, and clinical outcome. For cross-stratum evaluations, the Mantel-Haenszel test (MH) was used, and within individual strata, Fisher exact test was used for analysis.
Results A total of 158 patients (mean [SD] age, 49.1 [18.0-82.0] years; 93 [58.9%] male) were randomized into 1 of 3 groups: 55 (34.8%) in SMT, 53 (33.5%) in WBV, and 50 (31.6%) in treatment as usual (TAU).
The incidence of CIPN in participants was significantly lower in both intervention groups compared to the control group (TAU): (SMT, 12 of 40 [30.0%; 95% CI, 17.9%-42.1%] and WBV, 14 of 34 [41.2%; 95% CI, 27.9%-54.5%] vs TAU, 24 of 34 [70.6%; 95% CI, 58.0%-83.2%]; P = .002 for intention to treat–MH).
Improvements in favor of SMT compared to TAU were found for balance control bipedal with eyes open; bipedal with eyes closed; monopedal, vibration sensitivity, sense of touch, lower leg strength, pain reduction, burning sensation, chemotherapy dose reductions, and mortality.
Conclusion and Relevance This randomized clinical trial provides initial evidence that neuromuscular training decreases the onset of CIPN.
“Certain physical exercises may prevent nerve damage caused by chemotherapy among individuals being treated for cancer, results of a randomized study published in JAMA Internal Medicine showed…
“But this side effect (CIPN) not only affects their quality of life, it also influences their medical therapy as it can cause therapy alterations, [including] dose reductions or even termination,” she added. “Furthermore, it can impact their ability to work, the necessity for assistance in their activities of daily living, impact sleep quality, as well as cause additional health costs and medication…”
CIPN is a clinically relevant adverse effect for some patients after chemotherapy that can negatively impact a patient’s quality of life for weeks, months or even years.
A current lack of options to treat CIPN can cause patients to change cancer therapies, sometimes also reducing survival…
Researchers conducted a prospective clinical trial to determine whether sensorimotor training and whole-body vibration training could reduce symptoms and decrease the onset of CIPN of patients undergoing treatment with oxaliplatin or vinca alkaloids…
Of the 158 total patients, 55 (34.8%) received sensorimotor training and 53 (33.5%) received whole-body vibration training twice a week for 15 to 30 minutes per session, while another 50 (31.6%) received standard treatment…
Study participants who received either sensorimotor training (12 out of 40, 30%; 95% CI, 17.9-42.1) or whole-body vibration training (14 of 34, 41.2%; 95% CI, 27.9-54.5) had a significantly lower incidence of CIPN compared with the control group (24 of 34, 70.6%; 95% CI, 58-83.2).
Patients who received vinca alkaloids and performed sensorimotor training benefited the most among those in the study…
In per-protocol analysis, researchers noted more pronounced results in patients who achieved greater than 75% participation in the intervention…
Noted improvements in favor of sensorimotor training over standard treatment included