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Colon Cancer Prevention with Curcumin
Colon cancer prevention with curcumin is one of many tools I am utilizing. My name is Bernie Davis. I was recently diagnosed with colon cancer. I had the tumor surgically removed, and I’m researching evidence-based non-conventional therapies such as curcumin to help me prevent a colon cancer relapse.
I will probably undergo adjuvant chemotherapy. I really don’t like the thought of undergoing chemotherapy but I believe that I can enhance the efficacy of my chemo while reducing the negative effects of it with supplements like curcumin as well as a healthy gut microbiome.
Turmeric Curcumin and Colon Cancer
As you can see, my approach to managing my colon cancer is to utilize the best of both conventional, FDA approved therapies, such as surgery and adjuvant chemotherapy as well as:
- Prehabilitation,
- Diet,
- Nutritional supplementation,
- and lifestyle therapies.
Have you been diagnosed with colon cancer? What stage? What therapies have you had? Scroll down the page, post a question or a comment and I will reply to you ASAP.
Thanks,
- Bernie Davis
- Colon Cancer Survivor
Anticancer Properties of Curcumin Against Colorectal Cancer: A Review
Abstract
Colorectal cancer (CRC) is one of the most common and recurring diseases, as well as the world’s second largest cause of mortality. Despite existing preventative, diagnostic, and treatment methods, such as chemotherapy, the number of instances rises year after year.
As a result, new effective medications targeting specific checkpoints should be developed to combat CRC. Natural compounds, such as curcumin, have shown significant anti-colorectal cancer characteristics among medications that can be used to treat CRC.
These chemicals are phenolic compounds that belong to the curcuminoids category. Curcumin exerts its anti-proliferative properties against CRC cell lines in vitro and in vivo via a variety of mechanisms, including the suppression of intrinsic and extrinsic apoptotic signaling pathways, the stoppage of the cell cycle, and the activation of autophagy.
Curcumin also has anti-angiogenesis properties. Thus, this review is aimed at emphasizing the biological effect and mode of action of curcumin on CRC. Furthermore, the critical role of these substances in CRC chemoprevention was emphasized…
Curcumin alters the colorectal cancer stem cell growth via growth factor modulation, cell death, and epigenetic alteration (1). Hence, the major reason for this study is to emphasize the significance of curcumin as a source of anticancer medications against colorectal cancer by focusing on its pharmacological activities in chemoprevention…
Curcumin sensitizes human colorectal cancer to capecitabine
Because of the poor prognosis and the development of resistance against chemotherapeutic drugs, the current treatment for advanced metastatic colorectal cancer (CRC) is ineffective. Whether curcumin (a component of turmeric) can potentiate the effect of capecitabine against growth and metastasis of CRC was investigated…
The effect of curcumin on the growth and metastasis of CRC was also examined in orthotopically implanted tumors in nude mice. In vitro, curcumin inhibited the proliferation of human CRC cell lines, potentiated capecitabine-induced apoptosis, inhibited NF-kappaB activation and suppressed NF-kappaB-regulated gene products.
In nude mice, the combination of curcumin and capecitabine was found to be more effective than either agent alone in reducing tumor volume (p = 0.001 vs. control; p = 0.031 vs. capecitabine alone), Ki-67 proliferation index (p = 0.001 vs. control) and microvessel density marker CD31.
The combination treatment was also highly effective in suppressing ascites and distant metastasis to the liver, intestines, lungs, rectum and spleen. This effect was accompanied by suppressed expression of activated NF-kappaB and NF-kappaB-regulated gene products (cyclin D1,c-myc, bcl-2, bcl-xL, cIAP-1, COX-2, ICAM-1, MMP-9, CXCR4 and VEGF).
Overall, our results suggest that curcumin sensitizes CRC to the antitumor and antimetastatic effects of capecitabine by suppressing NF-kappaB cell signaling pathway.
Colon cancer prevention with curcumin Colon cancer prevention with curcumin