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Colorectal Cancer Non-Conventional Therapies-

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Colorectal cancer has been shown to respond to many antioxidant supplements before, during and after diagnosis.

Image result for photo of colon cancer

Depending on your age, stage at diagnosis and your prognosis and therapy plan nutrition, supplementation and other lifestyle therapies can both enhance conventional therapies and/or kill colon cancer on their own.

The four studies linked and excerpted below are a few of the many evidence-based but non-conventional (not FDA approved) therapies that colorectal cancer patients and survivors should consider when learning about their colorectal cancer diagnosis and prognosis.

I am a long-term cancer survivor and cancer coach. I was diagnosed with my blood cancer in 1994 and was told “we can do nothing more for you” in September of 1997 after exhausting all conventional therapies for my cancer. I underwent a non-conventional cancer therapy called Antineoplaston Therapy from 11/97-4/99 and have been in complete remission from my “incurable cancer” ever since.

 I keep my cancer in complete remission by living an evidence-based. non-toxic, lifestyle through nutrition, supplementation, bone health, etc. therapies.

Have you been diagnosed with colorectal cancer? Scroll down the page, post a question or comment and I will reply to you ASAP.

Thank you,

David Emerson

  • Cancer Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:


Vitamin D and Colon Cancer

“”They found 107 systematic literature reviews, 74 meta-analyses of observational studies of plasma vitamin D concentrations, and 87 meta-analyses of randomized controlled trials of vitamin D — a huge body of literature that has been summarized and reviewed repeatedly, with a whole variety of nicely methodologically and statistically strong results. Where does it take us?
The role of vitamin D in colorectal cancer prevention, and possibly in treatment, is biologically plausible.

A vast literature has been summarized many times over. The conclusion of this umbrella review was that in cancer, particularly colorectal cancer, the evidence is suggestive of benefit for vitamin D…”

Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: a p53-independent induction of p21WAF1/CIP1 via C/EBPbeta.

“Colorectal cancer (CRC) is the second leading cause of cancer deaths in the United States. Five-fluorouracil (5FU) remains the single most effective treatment for advanced disease, despite a response rate of only 20%. Herein, we show that the antioxidants pyrrolidinedithiocarbamate and vitamin E induce apoptosis in CRC cells. This effect is mediated by induction of p21WAF1/CIP1, a powerful inhibitor of the cell cycle, through a mechanism involving C/EBPbeta (a member of the CCAAT/enhancer binding protein family of transcription factors), independent of p53. Antioxidants significantly enhance CRC tumor growth inhibition by cytotoxic chemotherapy in vitro (5FU and doxorubicin) and in vivo (5FU). Thus, chemotherapeutic agents administered in the presence of antioxidants may provide a novel therapy for colorectal cancer.

Melatonin potentiates flavone-induced apoptosis in human colon cancer cells by increasing the level of glycolytic end product

“Melatonin is a natural compound synthesized by a variety of organs. It has been described to possess cell protecting activity in normal cells but was shown to induce apoptotic cell death in cancer cells. We determined to which extent and based on which molecular mechanisms melatonin is able to cause apoptosis in HT-29 human colon cancer cells…

Our study provides evidence that melatonin potentiates flavone-induced apoptosis in HT-29 human colon cancer cells by enhancing the level of oxidizable substrates that can be transported into mitochondria in the presence of flavone.”

Alpha-Lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2-*-generation.

“In conclusion, our study provides evidence that ALA and DHLA can effectively induce apoptosis in human colon cancer cells by a prooxidant mechanism that is initiated by an increased uptake of oxidizable substrates into mitochondria.”

Leave a Comment:

9 comments
Older Colon Cancer Stage 3 Patients - Less Is More - PeopleBeatingCancer says 3 years ago

[…] Colorectal Cancer Non-Conventional Therapies- […]

Reply
Nancy says 6 years ago

Hello David.

My husband is 38 was diagnosed with colon cancer august 2015. There were no symptoms at all he had emergency surgery where they removed 14cm of his colon, several lymph nodes and they took a biopsy of his liver as they said it looked “sketchy”.

We were referred to Sunny Brooke hospital a few weeks later for the results.
The results were that the stage 4 cancer has spread I’m the liver and also the lymph nodes.

He goes for chemo every two weeks and has little side affects. We are waiting for ctscan results do see if the chemo has shrunk the lymph nodes.

We had a chat with his oncologist yesterday and felt we hit another red light (there’s been a few ). If the chemo is working my husband will carry on indefinitely . He wouldn’t give a straight answer! If it’s not working they will change the drugs. They won’t consider surgery and we are at the point now of getting a second opinion . We live near toronto and can access princess margerate.
We never leave there feeling positive in anyway and it’s hard coming home to out 7 and 2 year old girls. Living day to day not knowing.

My husband is doing everything on his side
Organic foods. No sugars red meats.
Meditation
Church
Homeopathic who prescribed him.
Melatonin (oncologist said not to take)
Vit d
Fermented wheat germ (oncologist said not to take )
Mistletoe. (Oncologist said not to take)

The oncologist recommended that non of the above mentioned be taken as they are high in anti oxidants and the chemo is a oxidant.

We have avoided the internet since his diagnoses as there are stories you simply cannot read until now, thankfully I came across your site first.
How do we find out about a Second opion ?

Best Nancy

Reply
    David Emerson says 6 years ago

    Hi Nancy-

    I am sorry to learn of your husband’s colon cancer diagnosis. It’s good to read that he is managing his chemotherapy with few side effects. Your husband’s young age is a double edged sword. You two have young kids but his age gives him strength to manage his cancer.

    You sound frustrated with your oncologist. Keep in mind that conventional chemotherapy is not curative for colon cancer that is diagnosed to have spread (stage 4). You must think outside the conventional oncology box in my opinion.

    I understand that conventional oncology advises against many non-conventional therapies such as antioxidant supplementation. You are between a rock and a hard place. The therapies offered by your oncologist are not going to cure your husband’s cancer yet your oncologist is not recommending those therapies that may help you and your husband manage his cancer.

    Regarding your question “How do we find out about a Second opion ?” I am not clear what you are asking though I will assume that you are wondering about getting a second opinion.

    I am not sure about how the Canadian health system handles payment for a second opinion. My hope is that you can contact another oncologist who is familiar with colon cancers and schedule and have another appt. to present your situation and ask any and all questions.

    There are a number of studies that show that antioxidants such as curcumin can enhance the EFFICACY while reducing the toxicity of chemotherapies such as FolFox or cisplatin. If you are interested in learning more about these therapies then you must tell me what chemotherapies your husband is undergoing. I can then provide the names of antioxidants along with the studies for you to consider.

    I don’t tell people what to do or not do. I can provide studies and research for you to decide on your own about issues and therapies.

    Princess Margaret is a fine hospital as far as I know. Are there other oncologists who understand colon cancer in your area?

    Please consider adding daily, moderate exercise to your husband’s routine (go for a brisk walk each morning). Many studies cite the importance of regular exercise for killing cancer.

    Do you have any questions?

    Hang in there,

    David Emerson

    Reply
Gary Hagen Subject: AHCC says 6 years ago

My father in law was recently (April,15) diagnosed with stage 4 colon cancer. I have been giving him Hemp/CBD oil once a day and Avemar ultra once a day, also. I wanted to add AHCC or another mushroom suppliment to aid in his recovery. He seems to be doing well. But, I just want to give him whatever it takes. Can you make a recomendation?

Reply
    David Emerson says 6 years ago

    Hi Gary-

    Has your FIL undergone any conventional therapies such as chemo, radiation and/or surgery? Keep in mind that none of these conventional therapies are curative. Regardless all of the therapies you mention, frequent, moderate exercise, eating well, CBD/Hemp, and Avemar all seem to be helping to maintain your FIL quality of life.

    As for long naps during the day don’t know enough to offer an opinion. My guess is that your FIL’s body is working really hard to fight his cancer. Really hard… My thinking about sleep is that if the desire to sleep is natural and not drug induced then it is our body telling us that it needs sleep. It is a therapy.

    There are other non-conventional, non-toxic, evidence-based therapies if you would like to learn more. I can email the studies if you would like. Up to you…I guess I am advocating a sort of throw everything but the kitchen sink at your FIL’s cancer. Up to you.

    David Emerson

    Reply
Ruth says 7 years ago

My mum is just about to start her chemo 5fu this week. How much of vitamin e and Coq 10 should she take per day? Her prognosis is good. Low grade and none in any of the 16 lymph nodes. Reason she’s been asked to undergo chemo is because of her positive margin, some cancer cells have been left behind. I’d like to help her get through 6 months of chemo with little side effects. She’s 71 yo with history of manageable high blood pressure but in good health otherwise.

Reply
    David Emerson says 7 years ago

    Hi Ruth-

    I am sorry to read of your mother’s colorectal cancer diagnosis. However I am happy to read that her prognosis is good and that you are recommending that she undergo supplementation during her 5-FU chemotherapy.

    The article that you came in on “Colorectal cancer non-conventional therapy supplementation…” links evidence-based research citing how various supplements kill colorectal cancer cells, enhance the efficacy of 5-FU and/or reduce the collateral damage (side effects) of 5-FU.

    Since none of the studies linked in the post list specific doses, I can’t relay, with any specificity, what you are asking. If the studies don’t give the info, I don’t know. Further, my intent on writing the blog post was to propose the idea that 5-F chemotherapy is only effective in 20% of cases reportedly and that 5-FU chemotherapy often causes collateral damage and that the patient with therefore need help.

    Nutritional supplementation is that help. My suggestion then is to take the recommended dose on the supplement bottle. Probably 400mg daily but read the labels. I will say that the key to vitamin e, based on the research, is to take a broad spectrum vitamin E or “mixed Vitamin E Tocopherols (d-gamma, d-beta, d-delta) –

    The brand and dose of CoQ10 that I take is Doctor’s Best-

    The brand and dose of Vitamin E that I take is Now Vitamin E- full spectrum, natural-

    Let me know if you have any questions. Good luck to you and your mom.

    Take it easy,

    David Emerson

    Reply
joseph longo says 7 years ago

wife has colorectal cancer.surgury performed.has colostomy that can be reversed. tried chemo with 5fu but suffered chest pain. hospitalized and catherization showed weak heart. stopped chemo and now on radiation. oncologist believes cancer in lymph nodes.we have concerns that the radiation will destroy good cells as well as bad.please advise if there would be other solutions.

Reply
    David Emerson says 7 years ago

    Hi Joseph-
    I am sorry to read of your wife’s colorectal cancer diagnosis. If your wife had a colostomy performed in addition to cancer in her lymph nodes I will operate under the assumption that she is at an advanced stage.

    Yes, a common side effect of 5FU chemotherapy is heart damage. See the link below to possibly reverse the damage.

    5-Fluorouracil cardiotoxicity: reversible left ventricular systolic dysfunction with early detection.

    In short, you and your wife are between a rock and a hard place. Meaning the cancer is advanced enough to require toxic therapies aka chemo and or radiation. The only option that is evidence-based is to pursue “integrative” therapies. Meaning therapies that are designed to enhance the efficacy of chemo or radiation while reducing toxicity.

    Mitigation of Chemotherapy Side Effects

    I will excerpt key quotations of the linked info above- please click the link and read the LEF info carefully.

    “Vitamin E has been shown to protect against cardio-myopathies induced by chemotherapy. Vitamin E has also been used in combination with vitamin A and CoQ10 to reduce the side effects of the chemotherapy drug Adriamycin (doxorubicin). Vitamin E is complementary to chemotherapy in that it boosts the effectiveness of these drugs. One study showed enhanced efficacy of both 5-FU and doxorubicin against human colon cancer cells, with vitamin E supplementation (Chinery et al. 1997).”

    “CoQ10
    CoQ10 is used with vitamin E to protect patients from chemotherapy-induced cardiomyopathies. CoQ10 is nontoxic even at high dosages and has been shown to prevent liver damage from the drugs Mitomycin C and 5-FU. Adriamycin-induced cardiomyopathies have been prevented by concomitant supplementation with CoQ10.”

    Let me know if you have any questions. Good Luck-

    David Emerson

    Reply
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