Recently Diagnosed or Relapsed? Stop Looking For a Miracle Cure, and Use Evidence-Based Therapies To Enhance Your Treatment and Prolong Your Remission
Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
Click the orange button to the right to learn more about what you can start doing today.
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Counteract Chemo-induced Senescence
I am a long-term Multiple Myeloma survivor. One of my long-term goals is to counteract chemo-induced senescence. I sustained chemo-induced senescence by undergoing FDA approved standard-of-care induction therapies and an autologous stem cell transplant in 1995 for the treatment of my incurable blood cancer.
Until now, I have been doing therapies to heal/counteract my therapy-induced senesence with
- Exercise
- Nutrition
- Supplementation
- Lifestyle therapies
Based on the studies linked below, I will add Salvia haenkei (Haenkenium (HK) to my supplement regimen.
Healing treatment-induced senescence-
For the record, I am not pursuing counteracting therapy-induced senescence in hopes of finding some sort of fountain of youth. I’ve sustained far too many long-term side effects.
What I am hoping to do is to prevent established long-term side effects from my many therapies such as a secondary cancer.
Email me at David.PeopleBeatingCancer@gmail.com with questions about managing your multiple myeloma.
Thanks,
David Emerson
- MM Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice
“Accumulating senescent cells within tissues contribute to the progression of aging and age-related diseases. Botanical extracts, rich in phytoconstituents, present a useful resource for discovering therapies that could target senescence and thus improve healthspan.
Here, we show that daily oral administration of a standardized extract of Salvia haenkei (Haenkenium (HK)) extended lifespan and healthspan of naturally aged mice.
HK treatment inhibited age-induced inflammation, fibrosis and senescence markers across several tissues, as well as increased muscle strength and fur thickness compared with age-matched controls. We also found that HK treatment reduced acutely induced senescence by the chemotherapeutic agent doxorubicin, using p16LUCreporter mice…
Aging is associated with a rise in age-related disorders such as cancer, cardiovascular, metabolic, kidney and neurodegenerative diseases, which represent the leading causes of death worldwide2,3,4…
It is now widely accepted that treating aging as a whole, rather than single pathologies, may represent a more impactful strategy to tackle age-related disorders and increase the healthspan of older adults6. The accumulation of senescent cells within the body is a main contributor to organismal aging7,8. Cellular senescence, defined as a stable arrest of cell division, can be triggered by exogenous cellular insults such as DNA-damaging agents, ultraviolet (UV) irradiation or endogenous cellular stressors such as age-associated telomere attrition or the expression of oncogenes…
It has been demonstrated that the selective removal of senescent cells can increase lifespan and restore the healthspan of aged animals11,12,13,14,15. Botanical extracts have long been used to treat age-related diseases in indigenous, traditional or folk medicines16. An expanding body of research has identified phytochemical constituents (for example, polyphenols, flavonoids, terpenoids) with putative anti-aging properties17,18…
In the present study, we test the in vivo anti-aging potential of a standardized extract of SH, referred to as Haenkenium (HK). We report that treating naturally aged mice with a daily low dose of HK in drinking water decreased the accumulation of senescent cells and alleviated several aging-related parameters, including lifespan, physical fitness, fibrosis, bone mineralization and inflammation.
HK treatment also decreased senescence in mice with therapy-induced senescence (TIS)…
HK administration was safe, and treatment did not result in alterations of hematopoietic parameters or organ toxicity, as assessed by histopathological evaluation of the skin, liver, kidney and lung of animals treated (Extended Data Fig. 1e,f).
Moreover, HK treatment, compared with control, did not induce changes in glucose concentration after either insulin or glucose injection, changes in daily average water intake, or alterations in lean and fat mass in male and female mice (Extended Data Fig. 1g–j)…”
Further assessment of Salvia haenkei as an innovative strategy to counteract skin photo-aging and restore the barrier integrity
“Skin is the essential barrier of the human body which performs multiple functions. Endogenous factors, in concert with external assaults, continuously affect skin integrity, leading to distinct structural changes that influence not only the skin appearance but also its various physiological functions.
Alterations of the barrier functions lead to an increased risk of developing disease and side reactions, thus the importance of maintaining the integrity of the epidermal barrier and slowing down the skin aging process is evident.
Salvia haenkei (SH) has been recently identified as a potential anti-senescence agent; its extract is able to decrease the level of senescent cells by affecting the IL1α release and reducing reactive oxygen species (ROS) generation…
Our data points out Salvia haenkei extract as a useful compound for either aiding barrier re-establishment or dampening the epidermal stress response. Concomitantly with the recent trial in humans, this work furnishes further insights into the mechanisms involved in the positive effect of the extract in skin aging.
This work, in support to the previous works [18, 46], identifies in a more peculiar way molecular mechanism linked to the efficacy of Salvia haenkei in modulating skin parameters, underlining the relevance of Salvia haenkei as an appealing agent useful for anti-ageing and ageing-related skin disorders.”
counteract chemo-induced senescence. counteract chemo-induced senescence.