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Cruciferous Veggies Kill Mesothelioma Enhance Cisplatin for Integrative Twofer

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The present study investigated the effects of Sulforaphane on enhancing the anticancer role of cisplatin in H‑28 malignant mesothelioma cells.

 Mesothelioma is one of the most aggressive cancers today. Conventional oncology is only a small part of the meso therapy picture. A chemotherapy such as cisplatin can kill meso, but cisplatin can kill more meso if it is enhanced with sulforaphane according to the article linked and excerpted below.

Image result for image of cruciferous vegetables

In case you don’t like eating broccoli I have good news. I take a supplement that combines several cruciferous veggies at once. Sulforaphane kills my cancer too it turns out.

I am a long-term survivor of an “incurable” cancer and cancer coach. Have you been diagnosed with mesothelioma? Scroll down the page, post a question or comment and I will reply to you ASAP.

Thank you,

David Emerson

  • Cancer Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

Pro-oxidant activity of sulforaphane and cisplatin potentiates apoptosis and simultaneously promotes autophagy in malignant mesothelioma cells.

“Sulforaphane (SFN) is an isothiocyanate compound derived from glucoraphanin, which is found in cruciferous vegetables, and has been heralded as a chemopreventive and/or chemotherapeutic agent. The present study investigated the effects of SFN on enhancing the anticancer role of cisplatin (cis-dichlorodiammineplatinum; CDDP) in H‑28 malignant mesothelioma cells

Pretreatment with the antioxidant N‑acetylcysteine attenuated both apoptosis and autophagy, whereas inhibition of autophagy by bafilomycin A1 potentiated apoptotic cell death following the combination treatment with SFN and CDDP. Considering the pro‑oxidant‑based combinational approach, the results of the present study provide a rationale for targeting cytoprotective autophagy as a potential therapeutic strategy for malignant mesothelioma.”

Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition

“Further characterization of the chemopreventive properties of sulforaphane and its capacity to be selectively toxic to malignant cells are warranted to potentially establish the clinical utility of the dietary compound as an anti-cancer compound alone, and in combination with clinically relevant therapeutic and management strategies…”

Cruciferous vegetables

“Cruciferous vegetables contain glucosinolates which are under basic research for their potential properties of affecting some types of cancer.[2][3][4][5] Glucosinolates are hydrolyzed to isothiocyanates (ITCs) by the action of myrosinase.[6] ITCs, possibly a bioactive component in cruciferous vegetables, are being investigated for their chemopreventive and chemotherapeutic effects…”

 

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