“curcumin reverses chemo-resistance and sensitizes cancer cells to chemotherapy and targeted therapy in breast cancer”
There are now a number of studies discussed on PeopleBeatingCancer that establish that curcumin can both enhance the anti-cancer action of certain chemotherapies as well as reduce cancer proliferation. The study linked below discusses how “curcumin reverses chemo-resistance and sensitizes cancer cells to chemotherapy and targeted therapy in breast cancer (BC).”
The devil is in the details as the saying goes. I supplement with a form of curcumin that has been shown to be much more bioavailable (absorbable in the blood). I believe using this formula is essential for us cancer patients. I use and recommend Life Extension Super Bio Curcumin.
I am a cancer survivor and cancer coach. If you are interested in learning more about evidence-based, non-toxic BC therapies please scroll down the page, post a question or comment and I will reply to you ASAP.
- Cancer Survivor
- Cancer Patient
- Director PeopleBeatingCancer
“Abstract: Curcumin, a principal component of turmeric (Curcuma longa), has potential therapeutic activities against BC through multiple signaling pathways. Increasing evidence indicates that curcumin reverses chemo-resistance and sensitizes cancer cells to chemotherapy and targeted therapy in breast cancer.
To date, few studies have explored its potential antiproliferation effects and resistance reversal in antiestrogen-resistant breast cancer. In this study, we therefore investigated the efficacy of curcumin alone and in combination with tamoxifen in the established antiestrogen-resistant breast cancer cell lines MCF-7/LCC2 and MCF-7/LCC9.
We discovered that curcumin treatment displayed anti-proliferative and pro-apoptotic activities and induced cell cycle arrest at G2/M phase. Of note, the combination of curcumin and tamoxifen resulted in a synergistic survival inhibition in MCF-7/LCC2 and MCF-7/LCC9 cells. Moreover, we found that curcumin targeted multiple signals involved in growth maintenance and resistance acquisition in endocrine resistant cells. In our cell models, curcumin could suppress expression of pro-growth and anti-apoptosis molecules, induce inactivation of NF-κB, Src and Akt/mTOR pathways and downregulate the key epigenetic modifier EZH2.
The above findings suggested that curcumin alone and combinations of curcumin with endocrine therapy may be of therapeutic benefit for endocrine-resistant BC.”