Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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Curcumin anti-tumor effects were previously characterized in multiple myeloma…The antidepressant benefits of the (curcumin) have been supported by the results of a trial…
A diagnosis of cancer is difficult. A diagnosis of an incurable blood cancer, multiple myeloma (MM) is depressing. While there is a long and growing list of FDA approved multiple myeloma chemotherapy regimens, only curcumin is evidence-based, anti-inflammatory, non-toxic antioxidant show by research to kill multiple myeloma as well as be an antidepressant.
Evidence-based research shows that Super Bio-curcumin helps the human body/brain fight all these chronic diseases. I know because I have been taking Super Bio-curcumin since 2007. I am a long-term cancer survivor who has remained cancer-free since 1999.
Please read the study linked and excerpted below. Please consider supplementing with Life Extension Super Bio-curcumin. I take this formulation because it is more bioavailable and absorbed into my blood. Also,Super Bio-curcumin has been tested and approved by ConsumerLab.com an independent testing service.
I am both a multiple myeloma survivor and MM cancer coach. I take CUR daily for it’s anti-cancer properties but it may be CUR’s effect on my mind that has kept me cancer-free since ’99.
For more information about nutritional or lifestyle therapies to manage multiple myeloma and depression, scroll down the page, post a question or a comment and I will reply ASAP.
“Multiple myeloma (MM), a plasma cell malignancy, remains incurable despite the development of new therapies. Curcumin anti-tumor effects were previously characterized in multiple myeloma, however only few MM cell lines were included in these studies. Since myeloma is a heterogeneous disease it is important to address the impact of myeloma molecular heterogeneity in curcumin cell death induction.
Myeloma cell lines harboring the t(11;14) translocation were less sensitive (median LD50 32.9 μM) than non-t(11;14) (median LD50 17.9 μM), which included poor prognosis t(4;14) and t(14;16) cells.
Interestingly, curcumin sensitivity was not dependent on TP53 status. For the first time we showed that primary myeloma cells were also sensitive, even those displaying del(17p), another poor prognosis factor. We also unravel the contribution of anti-apoptotic Bcl-2 family molecules in curcumin response. We found that down-regulation of Mcl-1, an essential MM survival factor, was associated with curcumin-induced cell death and its knockdown sensitized myeloma cells to curcumin, highlighting Mcl-1 as an important target for curcumin-induced apoptosis. Altogether, these results support clinical trials including curcumin in association with standard therapy.
“The antidepressant benefits of the Indian spice turmeric have been supported by the results of a trial run by a Murdoch University researcher…
“There have been a few positive human-based studies investigating the effects of curcumin in depression. However, this is the first randomised, double blind, placebo-controlled study and over the longest duration…”
“The findings from this study suggest that depression can be treated with an agent that has anti-inflammatory and antioxidant properties,” he added.
“Our findings support consistent research that depression is associated with increased inflammation. Despite what has been previously believed, depression is not all about brain chemicals such as serotonin…”
“A search of the Pubmed database for the word curcumin yields 601 studies spaning health topics from multiple myeloma (MM) and colorectal cancer, to chemotherapies that synergizes with CU, to Alzheimer’s Disease, arthritis and more. Based on years of reading studies and personal accounts, I think it is safe to say that CU supplementation is safe and relatively inexpensive.
I have read about myeloma patients taking daily doses of CU from 400 milligrams to 8 grams (1000 milligrams = 1 gram). By almost any measure, CU is a safe, inexpensive wonder drug.
The only challenge is that CU is famously difficult to absorb in the body. In other words, a person has to mix curcumin with some sort of fat (coconut oil, chocolate, etc.) or take a brand of curcumin capsule that is already formulated to be more “bioavailable” in order to derive the full benefit of CU.
The study linked and exerpted below reviews different formulations of CU. The study itself lists the three most bioavailable formulation/brand of CU and I’ve added an excerpt from a further review from Consumerlab.com that lists four additional bioavailable brands of CU.
I consult the independent evaluation service Consumerlab.com frequently. For one low annual payment, I can read about and evaluate all of the nutritional supplements that I take.
Please watch the video below to learn more about the evidence-based, integrative therapies to combat treatment side effects and enhance your chemotherapy.
“CU is a bright yellow chemical produced by some plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. It is sold as an herbal supplement, cosmetics ingredient, food flavoring, and food coloring.“
“Are you looking for a way to boost every facet of your health with a single spice? It sounds crazy, but turmeric curcumin with BioPerine may be the magic supplement we’ve been seeking. Turmeric benefits the body and mind in more ways than you can imagine. Similar to bone broth, turmeric impacts almost every facet of life. Over 10,000 peer-reviewed and clinical studies support using turmeric for better health…”
“Curcumin is a widely studied natural compound which has shown tremendous in vitro therapeutic potential. Despite that, the clinical efficacy of the native CU is weak due to its low bioavailability and high metabolism in the gastrointestinal tract. During the last decade, researchers have come up with different formulations with a focus on improving the bioavailability of curcumin. As a result, a significant number of bioavailable curcumin-based formulations were introduced with the varying range of enhanced bioavailability.
The purpose of this review is to collate the published clinical studies of CU products with improved bioavailability over conventional (unformulated) CU. Based on the literature search, 11 curcumin formulations with available human bioavailability and pharmacokinetics data were included in this review. Further, the data on clinical study design, analytical method, pharmacokinetic parameters and other relevant details of each formulation were extracted.