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Increases the effects of curcumin on inhibition of cellular growth in pancreatic cancer cells. More importantly, the new compound sensitized pancreatic cancer cells to gemcitabine…
If you are reading this post then you are probably a pancreatic cancer (PC) patient or caregiver. You probably already know that conventional oncology has little to offer the PC patient and that five-year survival rates for PC are dismal.
Try to look at conventional oncology’s inability to treat PC in a positive light. I didn’t do well when I relied exclusively on my oncologist. I began to do much better once I took control of my health.
Please don’t misunderstand me. I think conventional oncology- diagnostic testing, chemotherapy, radiation and even PC surgery called the Whipple Procedure– is all important for you to learn and understand. In fact, the goal of almost all pancreatic patients will be to shrink the tumor in order for it to be surgically removed. Pancreatic cancer is curable usually only after surgical removal of the tumor.
All I am saying is that once I learned to balance conventional and evidence-based non-conventional therapies I did much better. I supplement with Life Extension Super BioCurcumin as this brand and formula have been evaluated and approved by Consumerlab.com and independent testing company.
Please take a moment to watch the short video below in order to learn more about some of these therapies and how they can help you manage your Pancreatic Cancer:
Have you been diagnosed with PC? What stage? What therapies are you considering? Scroll down the page, post a question or comment and I will reply to you ASAP.
“Development of resistance to chemotherapeutic drugs is a major challenge in the care of patients with pancreatic ductal adenocarcinoma (PDAC). Acquired resistance to chemotherapeutic agents in PDAC has been linked to a subset of cancer cells termed ‘cancer stem cells’ (CSCs)…
Accumulating evidence indicates that curcumin, a phenolic compound extracted from turmeric, can overcome de novo chemoresistance and re-sensitize tumors to various chemotherapeutic agents...
Overall, this study indicates clinical relevance for combining curcumin with chemotherapy to overcome chemoresistance in PDAC…”
“A number of preclinical studies have demonstrated anticancer effects of curcumin in various types of tumors, including pancreatic cancer. Curcumin has anticancer effects both alone and in combination with other anticancer drugs (e.g., gemcitabine, 5-fluorouracil, and oxaliplatin), and it has been shown to modulate a variety of molecular targets in preclinical models, with more than 30 molecular targets identified to date..
However, the poor bioavailability of curcumin has been the major challenge to its clinical application. This problem has now been solved by the development of highly bioavailable forms of curcumin (THERACURMIN®), which can induce higher plasma curcumin levels without increased toxicity…”
“The present study demonstrates that water-soluble PEGylated curcumin conjugate that we generated increases the effects of curcumin on inhibition of cellular growth in pancreatic cancer cells. More importantly, the new compound sensitized pancreatic cancer cells to gemcitabine-induced cell apoptosis and growth inhibitory effects…”
“Pancreatic cancer is almost always lethal, and the only U.S. Food and Drug Administration-approved therapies for it, gemcitabine and erlotinib, produce objective responses in <10% of patients. We evaluated the clinical biological effects of curcumin (diferuloylmethane), a plant-derived dietary ingredient with potent nuclear factor-kappaB (NF-kappaB) and tumor inhibitory properties, against advanced pancreatic cancer…
Oral curcumin is well tolerated and, despite its limited absorption, has biological activity in some patients with pancreatic cancer…”
[…] have been shown to enhance the efficacy of these chemo regimens while reducing their toxicity. Further, curcumin has been shown to enhance the efficacy of gemcitabine chemotherapy in pancreatic […]
[…] The articles linked and excerpted below point out that because conventional oncology has little to offer pancreatic cancer patients, patients must think about both evidence-based non-conventional therapies such as ellagic acid and pomegranate extract as well as integrative therapies such as curcumin that has been shown to be cytotoxic to pancreatic cancer as well as enhance the efficacy of chemotherapy. […]
