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Curcumin, Pycnogenol, Antioxidants- Breast Cancer

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“The findings of both studies support a growing body of research that suggests lifestyle interventions lower biomarkers associated with breast cancer recurrence and mortality, and improve quality of life,” said one expert…”

I am contacted almost weekly by women hoping to learn about evidence-based, non-toxic therapies to both reduce the risk of breast cancer (BC) reduce the risk of a BC relapse or reduce the risk of side effects.

The links below are to studies that document the many lifestyle, nutrition, supplementation therapies that do just that- fight BC.

The devil is in the details as the saying goes. Anyone diagnosed with breast cancer would like to prevent a relapse, right? There needs to be a discussion with the breast cancer survivor of your stage at diagnosis, conventional therapies, age, goals, etc. are. In short, the goal is to figure out where you started, and where you want to go.

I have taken Life Extension Curcumin and Omega 3 Fatty acids for years now. I do because of their absorbability and the fact these supplements have been tested and approved by ConsumerLab.com.

I am both a cancer survivor and cancer coach. Have you been diagnosed with breast cancer? If so, what stage? What therapies are you considering or have you undergone already? Scroll down the page, ask a question or comment and I will reply to you ASAP.

Thank you,

David Emerson

  • Cancer Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:

Vitamins & Supplements SearchWeb MD- BC-

“Considering taking a vitamin or supplement to treat Breast Cancer? Below is a list of common natural remedies used to treat or reduce the symptoms of Breast cancer. Follow the links to read common uses, side effects, dosage details and read user reviews for the drugs listed below.”

Expression profiles of apoptotic genes induced by curcumin in human breast cancer and mammary epithelial cell lines.

“These results suggest that curcumin induces apoptosis in BC cells by regulation of multiple signaling pathways, indicating its potential use for prevention and treatment of cancer.”

Selective induction of apoptosis in human mammary cancer cells (MCF-7) by pycnogenol.

“In this study, we compared the response of human breast cancer cells (MCF-7) and normal human mammary cells (MCF-10) to apoptosis in the presence of pycnogenol. Pycnogenol is a mixture of flavonoid compounds extracted from the bark of pine trees. MCF-7 and MCF-10 cells were plated out in culture dishes and grown in medium containing 0, 40, or 80 micrograms pycnogenol/ml culture medium. Cells were harvested at confluency, incubated with DAPI for 15 min and viewed microscopically for evidence of apoptosis. Apoptosis is detectable by morphology, chromatin condensation, nuclear DNA fragmentation, DNA strand breakage or apoptotic bodies. DAPI is a DNA-binding fluorescent dye used to visualize DNA fragmentation. Apoptosis, as detected by DAPI staining, was significantly higher in MCF-7 cells treated with pycnogenol than the untreated cells. The presence of pycnogenol did not significantly alter the number of apoptotic cells in MCF-10 samples. These results suggest that pycnogenol selectively induced death in human mammary cancer cells (MCF-7) and not in normal human mammary MCF-10 cells.”

Curcumin inhibits cell proliferation of MDA-MB-231 and BT-483 breast cancer cells mediated by down-regulation of NFκB, cyclinD and MMP-1 transcription

Curcumin, an active constituent of turmeric, has been shown to possess inhibitory effect of cell proliferation and induction of apoptosis towards a broad range of tumors. Cell inhibition activities of curcumin behave differently in various cell types. To investigate the mechanistic basis for the cell inhibition of curcumin on breast cancer cell lines, we examine curcumin effect on NFκB, cell cycle regulatory proteins and matrix metalloproteinases (MMPs) in two BC cell lines (MDA-MB-231 and BT-483). Cell proliferation was performed by water-soluble tetrazolium WST-1 assay. The effect of curcumin’s on the activity of matrix metalloproteinase-1, 3, 9 was analyzed by RT-PCR. Cell cycle regulatory protein including cyclin D1, CDK4 and p21 were examined by immunochemistry. The expressions of NFκB in breast cancer cells treated with curcumin were studied by immunochemistry and western blot. The results from WST-1 cell proliferation assay showed that curcumin exhibited the anti-proliferation effect on MDA-MB-231 and BT-483 cells in a time- and dose-dependent manner.

Specialty supplements and breast cancer risk in the VITamins And Lifestyle (VITAL) Cohort.

“RESULTS: Current use of fish oil was associated with reduced risk of BC (HR, 0.68; 95% CI, 0.50-0.92). Ten-year average use was suggestive of reduced risk (P trend = 0.09). These results held for ductal but not lobular cancers. The remaining specialty supplements were not associated with BC risk: Specifically, use of supplements sometimes taken for menopausal symptoms (black cohosh, dong quai, soy, or St. John’s wort) was not associated with risk.”

Lifestyle changes improve biomarkers for breast cancer recurrence, mortality

“Lifestyle changes in the form of healthy eating and regular exercise can decrease biomarkers related to BC recurrence and mortality, a pair of interventional studies involving breast cancer survivors has found. “The findings of both studies support a growing body of research that suggests lifestyle interventions lower biomarkers associated with breast cancer recurrence and mortality, and improve quality of life,” said one expert…”

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