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Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.

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Curcumin vs. Multiple Myeloma: The scientific evidence continues to pile up

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“We observed that curcumin cell death induction was heterogeneous, of note 16 Human Myeloma Cell Lines were highly sensitive to curcumin…”

Curcumin (Cu) is one of the best examples I know of of an evidence-based non-conventional cancer therapy. The applications of this wonder therapy are too many to write about (but scroll down the page to read research citing the anti-MM, pro-kidney, pro-bone health action of curcumin supplementation.

I am both a multiple myeloma (MM) survivor and MM cancer coach. I have been researching and writing about multiple myeloma for years. I can honestly say that MM patients and survivors may want to learn about and employ both conventional (FDA approved) and evidence-based non-conventional therapies if they are to manage their “incurable” blood cancer.

Multiple Myeloma – Nutritional Supplementation 

 

Suffice to say that if you have been diagnosed with cancer, any cancer, you must learn about possible applications of this therapy to help you in the weeks, months and years ahead. In the age of super high tech oncology it is critical to learn about non-toxic therapies such as curcumin.

If you have been diagnosed with multiple myeloma, curcumin has been shown to be cytotoxic (kill) MM itself as well as enhance the efficacy of both Velcade and Revlimid.

Also, according to the study linked below, curcumin promotes kidney and bone health. Kidney and bone damage can be a life-long challenge for multiple myeloma survivors.

In short, curcumin is a wonder… supplement.

I supplement with Life Extension Curcumin Elite Turmeric Extract as this formula and brand are approved both for purity and bioavailability.

Please scroll down the page, post a question or comment and I will reply to you ASAP.

David Emerson

  • Multiple Myeloma Survivor
  • MM Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:

Cu induces cell death of the main molecular myeloma subtypes, particularly the poor prognosis subgroups.

“In the present study, a large panel of human myeloma cell lines (HMCLs) (n = 29), representing the main molecular MM subgroups, was screened for curcumin sensitivity. We observed that curcumin cell death induction was heterogeneous, of note 16 HMCLs were highly sensitive to curcumin and only 7 HMCLs were weakly sensitive.

Cell lines harboring the t(11;14) translocation were less sensitive (median LD50 32.9 μM) than non-t(11;14) (median LD50 17.9 μM), which included poor prognosis t(4;14) and t(14;16) cells.

Interestingly, Cu sensitivity was not dependent on TP53 status. For the first time we showed that primary myeloma cells were also sensitive, even those displaying del(17p), another poor prognosis factor.

Altogether, these results support clinical trials including curcumin in association with standard therapy.”

Cu and chronic kidney disease (CKD): major mode of action through stimulating endogenous intestinal alkaline phosphatase.

“Cu, an active ingredient in the traditional herbal remedy and dietary spice turmeric (Curcuma longa), has significant anti-inflammatory properties. Chronic kidney disease (CKD), an inflammatory disease, can lead to end stage renal disease resulting in dialysis and transplant. Furthermore, it is frequently associated with other inflammatory disease such as diabetes and cardiovascular disorders.

Recent studies have shown that increased intestinal permeability results in the leakage of pro-inflammatory molecules (cytokines and lipopolysaccharides) from gut into the circulation in diseases such as CKD, diabetes and atherosclerosis.

This effect of Cu on intestine can explain why, despite poor bioavailability, Cu has potential anti-inflammatory effects in vivo and beneficial effects on CKD.”

Cu  Promotes Femoral Fracture Healing in a Rat Model by Activation of Autophagy

“Results- Autophagy of rat femoral bone tissue was activated following fracture, increasing with time, reaching a peak at 24 hours. Imaging and histology showed that curcumin promoted the fracture healing in rats, which was reduced by treatment with 3-MA. Immunohistochemistry, immunofluorescence, and Western blot showed that curcumin treatment increased the expression of Beclin-1 and LC3-II, which were reduced by treatment with the autophagy inhibitor, 3-MA.

Conclusions-The findings of this study, in a rat model of femoral bone fracture healing, showed that curcumin promoted bone healing and autophagy, which were reduced by treatment with 3-MA, a known inhibitor of autophagy.”

Johns Hopkins doctor says this is the most powerful anti-cancer spice

“Dr. Saraswati Sukumar, from Johns Hopkins, has been studying Cu  for many years. The primary active ingredient in the spice turmeric, says Dr. Sukumar, is arguably the most potent anti-cancer nutrient in existence…

As many as 25% of all cancers have a direct link to chronic inflammation. That means keeping your systemic inflammation to a minimum is a powerful way to prevent this life-threatening disease.

But Cu doesn’t just target inflammation-related cancers. Other research shows that it also targets malignant cancer cells and alters their regulation of DNA. This causes the cancer cells to die. And, unlike chemotherapy, curcumin doesn’t harm healthy cells and DNA. So there aren’t any negative side effects…

Of course, Cu doesn’t just fight cancer. I showed you a few weeks ago how it can prevent heart attacks. But that’s still just the tip of the iceberg. This nutrient is one power-packed spice. It also “reduces blood cholesterol levels, prevents low-density lipoprotein oxidation, inhibits platelet aggregation, suppresses thrombosis and myocardial infarction, suppresses symptoms associated with Type II diabetes, rheumatoid arthritis, multiple sclerosis, and Alzheimer’s disease; inhibits HIV replication, suppresses tumor formation, enhances wound healing, protects against liver injury, increases bile secretion, protects against cataract formation, and protects against pulmonary toxicity and fibrosis,” explains Dr. Sukumar.”

 

Leave a Comment:

98 comments
howard aks says last year

What brand of curcumin do you recommend? thank you

Reply
    David Emerson says last year

    Hi Howard-

    I use Life Extension Foundation Curcumin Elite but there are many bioavailable formulas for you to consider.

    David Emerson

    Reply
Gladys says last year

Hello
What would be the dose of the elite turmeric for some with active mm

Reply
    David Emerson says last year

    HI Gladys-

    The studies I’ve read discussing that issue only talks about “a time and dose dependent manner” which I think means the more the longer the more effective. Plus many formulas contain different bioavailability formulas.

    David Emerson

    Reply
Melanie Easley says a couple of years ago

Hi David,
I have been recently diagnosed with MGus and am experiencing some mild numbness and tingling. I have been a plant based vegan for over 20 years as well as avid exerciser: walking- yoga- meditation
Since the diagnosis- I am scared and overwhelmed. I would appreciate any guides for supplementation-nutrition-or exercise you could send me.
Thank you,
Melanie

Reply
Maria G says a couple of years ago

What is the most effective dose for multiple myeloma? If turmeric is paired with black pepper, is that sufficient to increase bioavailability? I’d really like to know exactly how to supplement with this, whether to take curcumin directly or to take it through turmeric, and how much. Thank you.

Reply
    David Emerson says a couple of years ago

    Hi Maria-

    There are a variety of studies of curcumin and MM and only a few of those studies cite specific doses. For example one study I know of talks about a curcumin dose (no brand given) using 4 grams. I know of many patients with active MM who dose 8 grams a day. I take only 500 milligrams daily as my mm is in remission.

    My suggestion would be to start with a low daily dose of curcumin and see how you feel.

    Yes, black pepper has been shown to enhance the bioavailability of curcumin.

    David Emerson

    Reply
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Nora says a couple of years ago

Hi David, hope you are well. Since I am taking blood thinners daily, is taking curcumin supplementation alright? I was informed that curcumin induces bleeding.
Thanks
Nora

Reply
    David Emerson says a couple of years ago

    Hi Nora-

    That would be the kind of question you need to ask your GP or oncologist. The answer will depend on several different blood issues.

    thanks,

    David Emerson

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Lora Rosamond says a couple of years ago

How many capsules per day do you take or recommend?

Reply
    David Emerson says a couple of years ago

    Hi Lora-

    The daily dose varies for each individual. Curcumin studies talk about ” a time and dose dependent manner” meaning the more the better. I am in remission so I talk one capsule, 500 mg daily. Many with active MM take 2,4,6,8 GRAMS daily. In my opinion, it is more about anti-mm nutrition, anti-mm supplementation (not only curcumin but others shown to kill mm), anti-MM lifestyle.

    Throw a variety of anti-mm therapies at your MM.

    David Emerson

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Owen says 7 years ago

Hi. How much do you use daily ? I.e. how much Mg?

Reply
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