Immunotherapy drugs such as nivolumab (Opdivo), pembrolizumab (Keytruda) and ipilimumab (Yervoy) hold a great deal of promise for many difficult to treat cancers such as melanoma. Unfortunately, a large percentage of patients might not respond and those that do often respond with serious adverse events. In short, cancer patients considering immunotherapy want to take every step possible to insure that they respond well to this expensive therapy.
According to research, pre-habilitation improves outcomes for patients undergoing chemotherapy. The articles linked and excerpted below explain that a different kind of pre-habilitation might benefit cancer patients undergoing immunotherapy regimens.
In addition to pre-habilitating the newly diagnosed cancer patient by exercising, working on their sleep/rest, maybe even losing a few pounds- what if the patient changed to a high fiber diet, included yogurts and kefirs daily, etc. all in an effort to supercharge their microbiome?
According to the articles below, supercharging a newly diagnosed patient’s microbiome could dratically increase their response to immunotherapy and perhaps even reduce their risks of certain adverse events.
Are you considering immunotherapy? To learn more about your microbiome please scroll down the page, post a question or comment and I will reply to you ASAP.
“The effectiveness of drugs that help the immune system fight cancer cells appears to depend on bacteria in the gut
Culler and other oncology researchers hope to answer one of the most pressing questions in current cancer research: Does the quality and diversity of human gut bacteria determine whether people will successfully respond to cancer treatment?
“When we looked at stool from breast and lung cancer patients, we discovered that important bacteria were missing from the microbiome,” Culler says. The absence of certain gut microbes, mostly Firmicutes bacteria, could explain why immune checkpoint inhibitors—drugs that block cancer-friendly proteins and help facilitate the immune system’s response to cancer cells—don’t work on some patients. “We believe that those bacteria are important for the immune system to be able to respond to those drugs,” Culler says…
Over the last decade, there’s been a flurry of research exploring the microbiome’s role in everything from depression to autism to Parkinson’s disease. Studying the microbiome can help determine which patients are likely to respond to different pain and heart drugs, according to Rob Knight, founding director of the Center for Microbiome Innovation at the University of California San Diego. “We’re extremely interested in the interplay between food, drugs and the gut microbiome,” says Knight, who also cofounded the American Gut Project, a citizen science effort that has collected fecal samples from more than 11,300 participants in 42 countries…
Teams from the University of Chicago and University of Texas MD Anderson Cancer Center in Houston have conducted similar experiments using gut microbes from metastatic melanoma patients who responded well to checkpoint inhibitors…
We know that diet matters, but everyone wants to know what the secret sauce is to change the microbiome to respond better to cancer treatment,”
“People with a type of skin cancer who consumed a high-fiber diet responded better to immunotherapy treatment than those with poorer diets, according to data presented at a media preview of the American Association for Cancer Research (AACR) annual meeting…
Immunotherapy drugs such as those targeting PD-1/PD-L1 or CTLA-4 as well as T-VEC, the first ever viral therapy for cancer treatment to be FDA-approved, have had a remarkable impact on the survival from advanced melanoma. A study in 2001 calculated the chance of surviving 10 years after diagnosis to be under 10%, but now largely thanks to these immunotherapy agents, the survival rate has soared to over 50%.
However, some patients don’t respond to immunotherapy at all and although researchers have started uncovering evidence as to why this might be, with recent research suggesting tumors with more DNA mutations are more likely to respond, it is likely to not be one single reason but a combination of factors.
Last week a further study suggested that people with melanoma are less likely to survive if they are or have ever been smokers, with the researchers suggesting that suppression of the immune system was likely responsible for this disparity. Now new research due to be presented at AACR has indicated that diet may be vitally important in determining whether melanoma patients respond to immunotherapies.
“We found that diet and supplements appear to have an effect on a patient’s ability to respond to cancer immunotherapy, most likely due to changes in their gut microbiome,” said Christine Spencer, PhD, research scientist at the Parker Institute for Cancer Immunotherapy.
The researchers collected fecal samples from 113 melanoma patients starting immunotherapy treatment at MD Anderson Cancer Center. They looked at the types of bacterial species found in the patients’ gut microbiome and found that a higher microbiome diversity was correlated with a better response to immunotherapy after controlling for differences based on age, sex and body mass index (BMI)…”
The researchers also noted that about 40 percent of the people in the study were taking a probiotic supplement. Probiotics contain live bacteria believed to be helpful to maintaining the balance of the microbiome. However, the researchers found that probiotic use was actually linked to lower diversity of the gut microbiome.
And, a lower diversity of the microbiome has been linked to a poorer response to melanoma immunotherapy, the researchers noted…”