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Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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Diet Gut Microbiome and Myeloma
How do diet gut microbiome and myeloma all fit together? While the research is in its infancy, both the studies linked below and the video of Dr. Urvi Shah below outline a number of studies that cite nutrition and the microbiome as having a measurable influence on many aspects of multiple myeloma.
Dietary and microbiome evidence in myeloma & other plasma cell disorders
I try to follow as vegetarian a diet as I can. However, when meat appears on the dinner plate in front of me, my general rule is to eat as lean beef, chicken, turkey, etc. as possible.
In addition, I do supplement with probiotics. I eat some yogurt and fermented foods when I can.
Have you been diagnosed with multiple myeloma? How is your diet? Chemo and antibiotics, if you’ve had them, can damage your gut health.
Email me at David.PeopleBeatingCancer@gmail.com to learn more about diet, nutritional supplementation and MM.
David Emerson
- MM Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
Gut microbiome signatures of vegan, vegetarian and omnivore diets and associated health outcomes across 21,561 individuals
“Abstract
As plant-based diets gain traction, interest in their impacts on the gut microbiome is growing. However, little is known about diet-pattern-specific metagenomic profiles across populations.
Here we considered 21,561 individuals spanning 5 independent, multinational, human cohorts to map how differences in diet pattern (omnivore, vegetarian and vegan) are reflected in gut microbiomes.
Microbial profiles distinguished these common diet patterns well (mean AUC = 0.85). Red meat was a strong driver of omnivore microbiomes, with corresponding signature microbes (for example, Ruminococcus torques, Bilophila wadsworthia and Alistipes putredinis) negatively correlated with host cardiometabolic health.
Conversely, vegan signature microbes were correlated with favourable cardiometabolic markers and were enriched in omnivores consuming more plant-based foods.
Diet-specific gut microbes partially overlapped with food microbiomes, especially with dairy microbes, for example, Streptococcus thermophilus, and typical soil microbes in vegans. The signatures of common western diet patterns can support future nutritional interventions and epidemiology…
By contrast, a diet rich in animal foods leads to increased protein fermentation, which may result in a leaky mucosa, local and systemic inflammation and reduced production of SCFAs8. For example, the breakdown of certain animal proteins is linked to the synthesis of gut microbial trimethylamine (TMA), which is oxidized in the liver to trimethylamine N-oxide (TMAO)6. TMAO has been implicated in various (cardio)vascular diseases and is a potential contributing factor in colorectal cancer9…
Gut microbial diversity and composition across diet patterns
Gut microbial richness differed significantly according to diet patterns in the PREDICT cohorts (Kruskal–Wallis, P < 0.05; Supplementary Table 4), with a lower observed richness in vegans (median between 209 and 266 species-level genome bins (SGBs)) and vegetarians (median 201–269) compared with omnivores (median 217–299; Fig. 1b and Supplementary Table 5), but no significant differences between vegans and vegetarians (Dunn’s test, P > 0.05; Supplementary Tables 6 and 7). This highlights that alpha diversity might correlate with diet patterns that are potentially more diverse…
Discussion
Following diets that include or exclude major food groups such as meat, dairy, fruits and vegetables leaves its mark on the gut microbiome, which we characterized here by leveraging an integrated, multinational, metagenomic cohort of unprecedented size (21,561 individuals) with self-reported diet patterns.
We found strong microbiome configurations for vegans, vegetarians and omnivores with several characteristic microbes that confirm and expand upon several previous findings. Among the 488 microbial signatures of an omnivore gut microbiome, we found species such as A. putredinis, B. wadsworthia and R. torques, that were generally linked to meat (especially red versus white meat) consumption.
These species have been previously implicated in inflammatory diseases such as inflammatory bowel disease, colorectal cancer and an overall decrease in SCFAs, and were more likely to be associated with negative cardiometabolic health outcomes19,20,21.
In contrast, signature microbes of a vegan gut microbiome, such as Lachnospiraceae, Butyricicoccus sp. and R. hominis, were linked to the consumption of fruits and vegetables, for example, due to their specialized role in fibre degradation, and are commonly described as producers of SCFAs22,23,24,25,26…
In summary, our work reinforces how humans can shape their own gut microbiomes, and by extension their health, directly through simple dietary choices as well as more indirectly through agricultural and food production practices…”
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