“Despite excellent survival rates among children treated for Rb, survivors with a germline mutation in their Rb1 gene (hereditary Rb) are prone to subsequent cancers including sarcomas, melanoma, and cancers of the brain and nasal cavity.
All that being said, survivors of a rare pediatric cancer called retinoblastoma, have an increased risk for several other cancers. Keep in mind however, that a person, any person, can reduce his or her risks of a cancer diagnosis through evidence-based nutrition, supplementation, and other lifestyle therapies.
I am a long-term survivor of an “incurable” cancer and cancer coach. Are you an Rb survivor? Would you like to reduce your risk of secondary cancers? Please scroll down the page, post a question or comment and I will reply to you ASAP.
“Despite excellent survival rates among children treated for Rb, survivors with a germline mutation in their Rb1 gene (hereditary Rb) are prone to subsequent cancers including sarcomas, melanoma, and cancers of the brain and nasal cavity. Radiotherapy appears to increase the risk, suggesting a gene-environment interaction…”
After reading a National Cancer Institute study on the genetic predisposition of retinoblastoma survivors I asked a retinoblastoma Facebook group “Retinoblastoma Awareness” about their secondary cancers experiences. Compare research results to patient/caregiver experiences below.
Are retinoblastoma survivors genetically predisposed to other cancers?
Linda YoakleyHi – my daughter was diagnosed with a mosaic version of RB last August and lost her right eye – but her life is saved. My understanding from the genetecist is yes, a slightly higher risk – she should never smoke, wear high sun factor and check any lumps or bumps out.
David EmersonLinda- thank you for this reply. I read a study that alluded to RB survivors being at a slightly increased risk for other cancers but I wanted to ask RB survivors/caregivers about it. Thank you-
Linda YoakleyDavid. Not sure if you will see this now. I only saw your reply today! Sorry. I meant to also say, aside from the obvious of smoking, radiation is a no no too apparently. I’m sure this must be different to radiation given to treat RB but I was told to steer my daughter clear of radiation when possible. A genetecist could give you the official answer
Deb Lockwood RogersHi David, I am the mother of a 24 year old Bilateral RB survivor. I was never too concerned about other types of cancer until last month. My beautiful Daughter has been diagnoised with LM Sarcoma, directly related to her RB and the radiation she had. This is an extremely rare cancer so I am not trying to scare anyone but it does happen. This was not something that I ever could have expected. She is under going Chemo at this time. We are praying for a good outcome. God Bless!