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Doxorubicin, Brain Damage and Myeloma
Doxorubicin, brain damage and myeloma. Three different issues that can result in a lifetime of stress. I was diagnosed with a blood cancer called multiple myeloma in early 1994.
One of my induction therapies was a chemo regimen called doxorubicin. Dox can cause both heart damage and brain damage. Toxic stuff.
Could the brain damage caused by dox. result in a common side effect called chemotherapy-induced cerebral dysfunction aka chemobrain? I don’t know. I do know that I developed chemobrain following my 4 years of FDA approved, “safe and effective” induction therapy and an autologous stem cell transplant. Lots of toxicity. I can’t blame any one side effect on any one chemo regimens…
CHEMO BRAIN: BATTLING THE RED DEVIL
A possible solution, according to research linked below, is propolis extract. Propolis reduced inflammation in the brain which can reduce brain damage done by dox.
If you are struggling with chemobrain, I encourage you to participate in those therapies that have helped me including:
- Exercise-
- Brain Games-
- Sleep-
- Coping mechanisms like writing notes-
Are you struggling with multiple myeloma? With chemobrain? Email me at David.PeopleBeatingCancer@gmail.com with questions you have. Hang in there.
Thanks,
David Emerson
- MM Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
Pegylated liposomal doxorubicin for multiple myeloma
“The anthracycline doxorubicin has long been considered one of the most active agents for the treatment of MM (Barlogie 2004; Rajkumar 2009). The mechanisms responsible for the antiproliferative effects of doxorubicin involve the inhibition of DNA, RNA, and protein synthesis, leading ultimately to cell death (Meriwether 1972; Momparler 1976; Tewey 1984). However, treatment with doxorubicin may be complicated by acute and chronic side effects. The acute side effects of doxorubicin, such as myelosuppression, nausea, vomiting, and arrhythmias, are usually clinically manageable and reversible…
Propolis Extract Reduces Doxorubucin-Induced Brain Damage by Regulating Inflammation, ER Stress, Oxidative Stress, and Apoptosis
Doxorubicin (DOX) is the most widely used chemotherapeutic agent to treat various tumors. DOX treatment can damage many organs, including the brain, by causing oxidative stress.
Several antioxidant substances can lessen the effects of DOX or make antioxidant defense systems work faster. Propolis (PROP) is a powerful agent with various healing effects, including
- antioxidant,
- antiproliferative,
- and anti-inflammatory.
The point of this study is to look at the histopathological changes, apoptosis, and antioxidant effects of DOX on brain damage in rats.
To find out what kinds of phytochemicals were in PROP from the Karlıova region of Bingöl province, ultra-high-performance liquid chromatography (UHPLC-Orbitrap-HRMS) was used. Then, we made an ethanol extract of it.
A total of 28 healthy male Wistar albino rats, each 12 weeks old and weighing between 220 and 250 g, were included in the study. Rats were divided into four groups: control, PROP, DOX, and PROP+DOX. We applied the relevant treatments to the determined groups.
Following the application, we decapitated the rats under the appropriate conditions and collected blood and brain tissue samples. We examined oxidative stress parameters in blood samples and used brain tissue samples for histopathological, biochemical, and molecular analyses.
We determined DOX levels in the brain tissue samples using UHPLC-Orbitrap-HRMS. The findings obtained showed that the PROP extract improved DOX-induced brain tissue damage. In addition, PROP extract attenuated DOX-induced brain tissue inflammation, ER stress, apoptosis, and oxidative stress…
Conclusion
The results of this study suggest that DOX treatment causes the production of ROS, which in turn stimulates ROS-mediated direct apoptosis.
Moreover, ROS-induced endoplasmic reticulum stress results in the suppression of mitochondrial BCL2 and increased production of Bax, which in turn stimulates the formation of caspase-3, which causes apoptosis.
Once more, elevating ROS causes endoplasmic reticulum stress, which in turn causes NF-kB to develop in the nucleus. This, in turn, raises cytokine levels, promoting apoptosis. Nevertheless, we discovered that the administration of PROP extract inhibited these DOX-stimulated signaling pathways.
These results suggested that PROP extract may be an adjuvant therapy to lessen the adverse effects of DOX-dependent oxidative stress, ER stress, inflammation, and apoptotic effects on brain tissue.”
Doxorubicin brain damage and myeloma Doxorubicin brain damage and myeloma