Reduce Inflammation to Reduce MM Risk?

Evidence-Based, Non-Toxic, Non-Conventional Cancer Therapies Will Eliminate Inflammation-

If you’ve been diagnosed with pre-myeloma- SBP, MGUS or SMM- your blood disorder is not your worry. Your worry is progressing to full-blown multiple myeloma (MM).

When I was diagnosed with a single bone plasmacytoma in early 1994, I was told that there were no therapies to reduce my risk of MM. I was diagnosed with MM less than a year later.

After my MM diagnosis, chemotherapy and radiation put me into partial remission for less than a year. My conventional therapies didn’t cure MM but it did increase inflammation (INFL.). Most long-term cancer survivors know this.

But once I achieved complete remission aka cancer-free status, I changed my lifestyle, one thing at a time over a period of years. The net result of changes in my diet, developing a habit of anti-cancer nutrition, antioxidant supplementation, daily moderate exercise, more sleep, less stress.

All these simple lifestyle therapies kept me cancer-free. And I remain cancer-free despite my risk of cancer relapse or a therapy-related secondary cancer.

Chemoradation increases INFL. Losing weight, moderate regular exercise, supplementation such as curcumin, resveratrol, epigallocatechin gallate, genistein, lycopene, and anthocyanins are evidence-based, non-toxic, non-conventional cancer therapies.

The studies linked and excerpted below cite INFL. as a major cause of chronic disease and cancer. In a way I am a long-term test case. I will continue my evidence-based, non-toxic, non-conventional lifestyle and let’s see if my cancer returns of if I develop any chronic diseases as I age.

For more information about simple, inexpensive therapies to reduce your body’s INFL and reduce your risk of a MM diagnosis, scroll down the page, post a question or comment and I will reply ASAP.

thank you,

David Emerson

Long-term MM survivor
MM Cancer Coach
Director PeopleBeatingCancer

Why Cancer and Inflammation?

“Inflammation has long been associated with the development of cancer. This review will discuss the reflexive relationship between cancer and inflammation with particular focus on how considering the role of inflammation in physiologic processes such as the maintenance of tissue homeostasis and repair may provide a logical framework for understanding the connection between the inflammatory response and cancer…”

Pre-existing inflammation may promote the spread of cancer

“There is mounting evidence that chronic inflammation is linked to increased risk of tumor development. A new study is helping to shed light on the important link between inflammation and cancer, and how pre-existing inflammation may aid in the metastatic process…

Important findings from our research show how pre-existing inflammation may be one of the factors that accelerates metastasis to the inflamed site…”

Tocotrienols: inflammation and cancer.

“The distinct characteristics of cancer cells to proliferate, metastasize, evade apoptotic signals, and develop chemoresistance have been linked to the inflammatory response. Due to the involvement of multiple genes and various pathways, current drugs that target single genes have not been effective in providing a therapeutic cure. On the other hand, natural products target multiple genes and therefore have better success compared to drugs. Tocotrienols, the potent isoforms of vitamin E, are such a natural product…”

Targeting the inflammatory pathways to enhance chemotherapy of cancer.

“The identification of transcription factors such as NF-kappaB, STAT3, HIF-1 alpha and their gene products such as COX-2, cytokines, chemokines and chemokine receptors have laid molecular foundation for the decisive role of inflammation in carcinogenesis. Inflammation contributes to survival and proliferation of malignant cells, tumor angiogenesis, metastasis and reduced response to chemotherapy. In view of their involvement at different stages of tumor development, inflammatory pathways represent attractive targets for cancer prevention and therapy.”

The Most BioAvailable Curcumin Forumulas

“Based on a review of these studies, it is evident that better bioavailability of formulated curcumin (CU) products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism”

A search of the Pubmed database for the word curcumin yields 601 studies spaning health topics from multiple myeloma and colorectal cancer, to chemotherapies that synergizes with CU, to Alzheimer’s Disease, arthritis and more. Based on years of reading studies and personal accounts, I think it is safe to say that CU supplementation is safe and relatively inexpensive.

I have read about myeloma patients taking daily doses of CU from 400 milligrams to 8 grams (1000 milligrams = 1 gram). By almost any measure, CU is a safe, inexpensive wonder drug.

The only challenge is that CU is famously difficult to absorb in the body. In other words, a person has to mix curcumin with some sort of fat (coconut oil, chocolate, etc.) or take a brand of curcumin capsule that is already formulated to be more “bioavailable” in order to derive the full benefit of CU.

The study linked and exerpted below reviews different formulations of CU. The study itself lists the three most bioavailable formulation/brand of CU and I’ve added an excerpt from a further review from Consumerlab.com that lists four additional bioavailable brands of CU.

Curcumin

“CU is a bright yellow chemical produced by some plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. It is sold as an herbal supplement, cosmetics ingredient, food flavoring, and food coloring.^[1]“

Bioavailable curcumin formulations: A review of pharmacokinetic studies in healthy volunteers.

“Curcumin is a widely studied natural compound which has shown tremendous in vitro therapeutic potential. Despite that, the clinical efficacy of the native CU is weak due to its low bioavailability and high metabolism in the gastrointestinal tract. During the last decade, researchers have come up with different formulations with a focus on improving the bioavailability of curcumin. As a result, a significant number of bioavailable curcumin-based formulations were introduced with the varying range of enhanced bioavailability.

The purpose of this review is to collate the published clinical studies of CU products with improved bioavailability over conventional (unformulated) CU. Based on the literature search, 11 curcumin formulations with available human bioavailability and pharmacokinetics data were included in this review. Further, the data on clinical study design, analytical method, pharmacokinetic parameters and other relevant details of each formulation were extracted.

Based on a review of these studies, it is evident that better bioavailability of formulated curcumin products is mostly attributed to improved solubility, stability, and possibly low first-pass metabolism. The review hopes to provide a quick reference guide for anyone looking information on these bioavailable curcumin formulations.

Based on the published reports,

NovaSol® (185 x),
CurcuWin® (136 x ) and
LongVida® (100 x )

exhibited over 100-fold higher bioavailability relative to reference unformulated CU. Suggested mechanisms accounting for improved bioavailability of the formulations and details on the bioanalysis methods are also discussed.”

According to Consumerlab.com:

“Novasol has the highest bioavailability (185 x compared to unforumulated CU), followed by Curcuwin (136 x), Longvida (100 x), Meriva (48 x), BCM-95 (27 x), Curcumin C3 Complex + Bioperene (20 x), and then Theracumin (16 x).”

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Diagnosed with SMM, SPB, or MGUS?

Reduce Inflammation to Reduce MM Risk?

Evidence-Based, Non-Toxic, Non-Conventional Cancer Therapies Will Eliminate Inflammation-

Recommended Reading:

Why Cancer and Inflammation?

Pre-existing inflammation may promote the spread of cancer

Tocotrienols: inflammation and cancer.

Targeting the inflammatory pathways to enhance chemotherapy of cancer.

The Most BioAvailable Curcumin Forumulas

Recommended Reading:

Curcumin

Bioavailable curcumin formulations: A review of pharmacokinetic studies in healthy volunteers.

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