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Enhance Immunotherapy for Melanoma… Naturally?

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Melanoma is a Complicated, Aggressive Cancer That is Difficult to Treat. You Need the Best of Evidence-based Conventional and Non-Conventional Therapies 

You’ve been diagnosed with melanoma. Your cancer is in an advanced stage. Perhaps frontline therapies haven’t worked. Or perhaps these chemotherapy regimens have worked previously but you have relapsed.

Melanoma at a glance-

  • Risks UV Exposure, HPV, Genetics, Skin Pigment, Moles, Immunosuppression, Previous Skin Cancer Diagnosis, 
  • Symptoms- Mole, Shape (A,B,C,D,E), Itching, Bleeding, 
  • Diagnosis- Visual Inspection, Skin Biopsy, 
  • Prognosis Staging, In-situ, I, II, III, IV,  Five year survival rates
  • Therapy Conventional, Non-Conventional, Integrative, Alternative

You’ve seen all the advertising for Yervoy, Opdivo and Keytruda and you’re wondering if these immunotherapy drugs can help you. You’ve read that only a small portion of cancer patients even respond to therapy. You’ve read that these new high-tech chemotherapies are incredibly expensive. And there are the side effects too.

So what’s a cancer patient to do? Learn about and consider all evidence-based therapies. By evidence-based I  mean that you should look beyond what the FDA approves. There is a world of information and research out there that may help you.

Image result for image of gut bacteria

For instance, it is well-understood that “gut bacteria” can boost the immune system. We also know that check point inhibitors can boost immune response to specific cancers. The article linked and excerpted below talks about integrating checkpoint inhibitors AND specific bacteria to ramp up the tumor response to melanoma.

For more information about evidence-based conventional and non-conventional therapies for melanoma,  scroll down the page, post a question or comment and I will reply ASAP

thank you,

David Emerson

  • Cancer Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

Gut bacteria can dramatically amplify cancer immunotherapy

Introducing certain bacteria into the digestive tracts of mice with melanoma can help their immune systems attack tumor cells. The gains were comparable to treatment with anti-cancer drugs known as checkpoint inhibitors. The combination of bacteria and anti-PD-L1 nearly abolished tumor outgrowth, report scientists

Checkpoint inhibitors such as ipilimumab (Yervoy), nivolumab (Opdivo)  and pembrolizumab (Keytruda) have had a dramatic impact on treatment of several tumor types, including melanoma, lung cancer, head and neck cancers and others. But only a minority of patients — one-third or less — have a vigorous response. Cancer researchers have wondered why so few benefit…

They found that introducing the bacteria was just as effective as treating them with anti-PD-L1 antibodies, resulting in significantly slower tumor growth. Combining the benefits associated with the bacteria with anti-PD-L1 treatment dramatically improved tumor control...

There may be other bacteria that also contribute to this process, the researchers note, either positively or negatively. They are investigating other bacteria that could influence other immune therapies, such at the CTLA-4 pathway, exploited by ipilimumab.

A second study — from the Institut Gustave Roussy in Paris, published in the same issue of Science — found that antibiotics could disrupt the antitumor effects of ipilimumab. Replenishing lost microbes in germ-free and antibiotic-treated mice restored the drug’s anti-cancer effects...”

Higher gut bacteria diversity tied to slower metastatic melanoma progression

“”Greater diversity of bacteria in the gut microbiome is associated with both a higher response rate to treatment and longer progression-free survival…

“The microbiome appears to shape a patient’s response to cancer immunotherapy, which opens potential pathways to use it to assess a patient’s fitness for immunotherapy and to manipulate it to improve treatment…

 

 

 

 

 

Leave a Comment:

2 comments
Stacey Wolanek says a few months ago

What bacteria do you use? Do you think you should take immunotherapy?

Reply
    David Emerson says a few months ago

    Hi Stacey-

    I have a different cancer and I have not taken an immunotherapy drug. I have an increased risk of melanoma because of my stem cell transplant years ago. And I sat in the sun way to much as a teen. I keep a close watch on my skin and have had a number of pre-cancers removed but no melanoma yet.

    I posted about probiotics enhancing immunotherapies because I research and write about complementary and integrative cancer therapies for a number of different regimens.

    I do supplement with probiotics,. I take a broad spectrum probiotic called RAW Probiotics.

    Your question about taking immunotherapy has to do with your stage, previous therapies, age, goals, etc. I’m not trying to dodge your question, I’m simply saying that I can’t give you an complete answer.

    I hope this helps. Hang in there,

    David Emerson

    Reply
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