Recently Diagnosed or Relapsed? Stop Looking For a Miracle Cure, and Use Evidence-Based Therapies To Enhance Your Treatment and Prolong Your Remission
Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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Enhance Myeloma Immune Function w/ Collagen
Is it possible to enhance myeloma immune function with collagen peptides? Why would a multiple myeloma patient/survivor need to enhance their immune function anyway?
Chemotherapy can cause the MM patient to experience immunodeficiency beyond what is caused by the MM itself. In effect, immunodeficiency is both a symptom and a side effect for MM patients.
The usual therapy plan, and I’m generalizing here, is to give the MM patient successive rounds of chemotherapy, usually 2,3 or 4 at a time, in order to control the MM patient’s MM. Unfortunately, chemo after chemo eventually exhausts the MM patient’s immune system.
A possible solution is to boost the MM patient’s immune system. Conventional oncology can give the MM patient IVIG shots but they are expensive and can cause side effects.
As the study linked below explains, collagen can enhance immune function for MM patients. Therefore, immune boosting nutrition like collagen can help the MM patient to reduce the risk of infection.
Which FDA approved therapies for multiple myeloma cause immunodeficiency in patients?
Several FDA-approved therapies for multiple myeloma (MM) can cause immunodeficiency due to their mechanisms of action, leading to increased susceptibility to infections. These include:
1. Immunomodulatory Drugs (IMiDs)
- Lenalidomide (Revlimid)
- Pomalidomide (Pomalyst)
- Thalidomide (Thalomid)
Mechanism of Immunodeficiency: - Suppress T-cell and NK cell function, increasing infection risk.
- Cause lymphopenia and hypogammaglobulinemia (low antibody levels).
- Increase risk of opportunistic infections (e.g., Pneumocystis jirovecii pneumonia).
2. Proteasome Inhibitors (PIs)
- Bortezomib (Velcade)
- Carfilzomib (Kyprolis)
- Ixazomib (Ninlaro)
Mechanism of Immunodeficiency: - Impair dendritic cell and T-cell function.
- Inhibit antibody production by plasma cells.
- Increase risk of viral reactivations, such as herpes zoster.
3. Monoclonal Antibodies (mAbs)
- Daratumumab (Darzalex) – Targets CD38
- Isatuximab (Sarclisa) – Targets CD38
- Elotuzumab (Empliciti) – Targets SLAMF7
Mechanism of Immunodeficiency: - Daratumumab & Isatuximab deplete CD38+ immune cells, reducing T-cell and NK cell function.
- Elotuzumab affects NK-cell activation.
- Increase risk of bacterial and viral infections (e.g., respiratory infections).
4. Anti-BCMA Therapies
- Belantamab mafodotin (Blenrep) – Anti-BCMA antibody-drug conjugate
- Cilta-cel (Carvykti) – CAR-T therapy targeting BCMA
- Idecabtagene vicleucel (Abecma) – CAR-T therapy targeting BCMA
Mechanism of Immunodeficiency: - BCMA-targeting therapies deplete plasma cells, reducing immunoglobulin (Ig) levels.
- CAR-T therapies cause prolonged B-cell depletion and cytokine release syndrome (CRS), increasing susceptibility to infections.
- Patients often require IVIG replacement therapy.
5. Alkylating Agents (Chemotherapy)
- Melphalan – Used in autologous stem cell transplantation
- Cyclophosphamide
Mechanism of Immunodeficiency: - Cause bone marrow suppression, leading to neutropenia and lymphopenia.
- Reduce immune cell production, increasing the risk of bacterial, fungal, and viral infections.
6. Corticosteroids
- Dexamethasone
- Prednisone
Mechanism of Immunodeficiency: - Suppress T-cell function and inflammation.
- Increase risk of opportunistic infections (e.g., Pneumocystis jirovecii, fungal infections).
I am a long-term MM survivor. When I found a study that explained that over 50% of MM patients die from infection I realized that immunodeficiency caused by chemotherapy is a serious side effect.
Like bone, kidney, blood, etc. health, MM patients must work to enhance their immune systems.
Email me at David.PeopleBeatingCancer@gmail.com and let me know how is your immune system is doing.
Hang in there,
David Emerson
- MM Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
Effect of type II collagen extract on immunosuppression induced by methotrexate in rats
“Abstract
This study investigated the effect of type II collagen extract on SD rats with deteriorated immunity caused by methotrexate. The test samples were dosed once a day for 28 days by gastric gavage at dosage 250 mg/kg and 500 mg/kg after methotrexate treatment, and the changes on
- body weight,
- total blood leukocyte numbers,
- the percentages of B-cells,
- CD4+ T-cells
- and CD8+ T-cells in the blood and spleen were observed.
The changes on body weight, the total blood leukocyte numbers, the total lymphocyte numbers in the spleen, the ratio of CD4+ and CD8+ T-cells in the blood and spleen were increased significantly in type II collagen extract groups as compared with the control group.
According to the above results, type II collagen extract has an effect of increasing immune responses on rats with deteriorated immunity caused by methotrexate…
There are many immune cells in the body to perform immune function, and these cells are located in various tissues and organs of the body including blood, lymph nodes, spleen and gastrointestinal tract.
Immune cell members include lymphocytes, mononuclear cells, polynuclear leukocytes and platelets. Among them, the main cells responsible for the immune response are lymphocytes and mononuclear cells…
MTX is currently being used as an anticancer drug, rheumatoid drug, and immunosuppressive agent, and has an excellent effect on choriocarcinoma. The mechanism of MTX inhibits DNA synthesis by inhibiting folic acid reductase. In the immunosuppression model by MTX, it is generally known to evaluate the efficacy of immunologically active substances by observing changes in body weight, changes in B lymphocytes in spleen cells and blood, changes in CD4+, CD8+ cells (Artym et al., 2004)…
These results suggest that the type II collagen extract may contribute to changes in leukocyte counts caused by MTX and changes in CD8+ cell ratio in the blood.
It was also confirmed that there was a significant effect on the changes of B cell ratio, CD4+ and CD8+ cell ratio in the spleen.
In addition, the type II collagen extract did not show cytotoxicity, and it was also confirmed that the inhibition of NO production was significant. Therefore, it is thought that type II collagen extract may help to restore the immune function in the living body caused by impaired immune function.”
enhance myeloma immune function with collagen enhance myeloma immune function with collagen