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Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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Exercise May Slow Kidney Decline
You’ve been diagnosed with a blood cancer called multiple myeloma. Like many MM patients, one of your symptoms is kidney involvement. According to research, regular exercise may slow kidney decline.
Your oncologist will focus on treating your MM in an effort also to treat your kidney impairment. But also consider evidence-based non-conventional therapies to enhance or slow kidney decline.
What causes kidney problems in multiple myeloma? What is myeloma kidney?
My experience as both a long-term MM survivor and MM cancer coach is that MM patients must pursue the best of both conventional and non-conventional therapies to manage their incurable blood cancer.
Email me at David.PeopleBeatingCancer@gmail.com to learn more about managing your MM with the full spectrum of MM therapies.
Good luck,
David Emerson
- MM Survivor
- MM Cancer Coach
- Director PeopleBeatingCancer
Approximately 50% of multiple myeloma patients experience renal impairment(kidney involvement), either at diagnosis or during the course of the disease. The most common cause of this is myeloma kidney, also known as cast nephropathy, which results from abnormal proteins (light chains) produced by the cancerous plasma cells damaging the kidneys. While some level of impairment is common, the severity can range from mild to severe acute kidney injury, with roughly 2-4% of patients requiring dialysis.
Factors influencing kidney involvement
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Disease stage:
The presence and stage of the myeloma influence the likelihood and severity of kidney involvement.
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Definition of impairment:
Different studies use varying thresholds to define kidney impairment (e.g., serum creatinine levels or glomerular filtration rate), leading to variations in reported percentages.
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Precipitating factors:
Factors like infections, dehydration, and the use of non-steroidal anti-inflammatory drugs (NSAIDs) can worsen existing kidney problems.
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Severity of AKI:
Patients with severe acute kidney injury at presentation have a higher risk of mortality.
Consequences and outcomes
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Poor prognosis:
Kidney dysfunction in myeloma patients is associated with a poorer overall prognosis and increased risk of early death.
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Reversibility:
With effective chemotherapy and other treatments, a significant portion of kidney function can be recovered.
Key takeaways
- Kidney involvement is a common complication of multiple myeloma.
- Light chain cast nephropathy is the primary mechanism by which myeloma damages the kidneys.
- Early detection and treatment of kidney issues can improve patient outcomes and survival rates.
Regular Physical Activity May Slow Kidney Function Decline
TOPLINE:
Higher frequency of physical activity was associated with a 71% lower risk for accelerated decline in glomerular filtration rate (GFR) than physical inactivity in a general population of adults without diabetes, cardiovascular disease, or kidney disease.
METHODOLOGY:
- Researchers conducted a study to investigate the association between physical activity and measured GFR (mGFR) decline in 1837 individuals aged 50-64 years without self-reported diabetes, cardiovascular disease, or kidney disease at baseline.
- Physical activity was assessed at baseline via self-report using the Physical Activity Frequency, Intensity, and Duration questionnaire, with volume expressed in metabolic equivalent of task (MET) minutes per week.
- GFR was measured at multiple timepoints over 11 years using iohexol clearance.
TAKEAWAY:
- At baseline, 694 participants with mGFR met the World Health Organization (WHO) recommendation of at least 450 MET minutes per week. In this cohort, the median decline in mGFR was -1.06 mL/min/1.73 m²/year.
- A higher frequency of weekly physical activity (almost every day or approximately five times per week) was associated with a 71% lower risk for accelerated GFR decline than no physical activity (adjusted odds ratio, 0.29; 95% CI, 0.11-0.78).
- Participants engaging in physical activity almost daily experienced a slower mGFR decline by 0.47 mL/min/1.73 m²/year (P = .006).
- Physical activity frequency showed a dose-response trend, with higher frequency associated with a slower annual decline in mGFR (P = .001).
IN PRACTICE:
“Higher weekly PA [physical activity] frequency and adherence to the WHO PA recommendations are associated with a slower mGFR decline and a reduced risk of accelerated mGFR decline in a healthy general population,” the authors wrote.
“As an intervention targeting the drivers of CKD [chronic kidney disease], increased PA across all age groups globally offers a low-cost, high-impact strategy with significant economic benefits,” they added.
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