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Fenbendazole for Colon Cancer?
Fenbendazole for colon cancer? One of the first questions Bernie Davis, colon cancer survivor, asked me was “- I keep seeing things about fenbendazole, both as a regimen on its own and as an integrative therapy for CRC chemotherapy regimens. Is it safe?”
Answering this question for Bernie draws on my experience as a cancer coach as well as a survivor of a blood cancer called multiple myeloma.
One of the most important aspects of cancer therapies, either conventional or non-conventional, is if the treatment is “evidence-based.” Meaning, is there any research or evidence that shows efficacy and side effects of the treatment? As a cancer coach, I can’t recommend a therapy unless I can cite my own personal experience or cite studies that cite efficacy, dosing information, and possible side effects.
As a cancer survivor, I can tell you that my fellow cancer survivors will try almost anything if they think it can help them. I, too, tried shark cartilage, TCM, whole body hyperthermia, and more. But the fact is, without research, not just clinical trials, but research in its broadest form, these therapies are useless at the least, dangerous, and cost money, at the worst.
In the case of fenbendazole, I cannot cite any research about it and colon cancer. Fenben may be a legit colon cancer therapy, but all I can find is anecdotal evidence, meaning individuals who talk about fenben.
It’s interesting to me to see that the AI explanation about Fenben (below) and colon cancer mentions the anecdotal evidence of Joe Tippens. The “Tippens Protocol” is mentioned in online groups discussing all things multiple myeloma (my cancer). Joe Tippens reportedly attests to the efficacy of Fenben yet was taking Keytruda at the same time so how can anyone know if Fenben affected his cancer?
Based on current research,
Fenbendazole is not an approved or medically recommended treatment for colon cancer in humans. While some preclinical studies show potential anti-cancer effects in lab dishes and animals, no robust human clinical trials have established its safety or effectiveness for treating colon cancer. Fenbendazole is a veterinary drug, and its use by humans can be dangerous.
Research on fenbendazole and cancer
- Lab studies: In laboratory cell cultures, fenbendazole and its analog mebendazole have shown some ability to kill colon cancer cells, including those resistant to standard chemotherapy like 5-fluorouracil.
- Mechanism of action: The proposed anti-cancer mechanisms observed in these studies include:
- Disrupting microtubules, which are vital for cell division.
- Inhibiting cancer cell metabolism by reducing glucose uptake.
- Inducing apoptosis (programmed cell death).
- Inconsistent animal results: Results from animal studies have been inconsistent. Some studies showed no anti-cancer effect with fenbendazole alone, while others found that it slowed tumor growth in combination with other vitamins.
Why is fenbendazole not for human use
- Not FDA-approved: Fenbendazole is a veterinary drug and is not approved for human use by regulatory agencies like the FDA or EMA.
- Limited bioavailability: When taken orally by humans, fenbendazole is poorly absorbed into the bloodstream. This means it is unlikely to reach therapeutic concentrations in tumors outside of the gastrointestinal tract.
- Reported side effects: There have been reports of severe side effects in humans who self-administered fenbendazole based on anecdotal information. These include serious liver damage and blood problems.
- Anecdotal evidence is unreliable: Much of the interest in fenbendazole as a cancer cure stems from online anecdotal testimonials, such as the widely circulated story of a patient named Joe Tippens. However, Tippens was also undergoing an approved immunotherapy clinical trial (Keytruda), which is a proven treatment for some types of cancer. This makes it impossible to know if fenbendazole had any effect.
- Risk of delaying proven treatment: Relying on an unproven treatment like fenbendazole could cause patients to delay or forgo standard, effective cancer therapies, potentially worsening their prognosis.
When it comes down to managing a diagnosis of colon cancer, there are dozens of therapies, both conventional and non-conventional, to learn about and possibly include in the survivor’s therapy plan. Bernie Davis, as an example, can fill his time with dozens of evidence-based therapies.
If you have a question about Fenben or colon cancer, scroll down the page and send me a post. I will reply to you ASAP.
Hang in there,
David Emerson
- Cancer Survivor
- Cancer Coach
- Director PeopleBeatingCancer
Oral Fenbendazole for Cancer Therapy in Humans and Animals
Abstract
Fenbendazole is a benzimidazole anthelmintic agent commonly used to treat animal parasitic infections. In humans, other benzimidazoles, such as mebendazole and albendazole, are used as antiparasitic agents.
Since fenbendazole is not currently approved by the FDA or EMA, its pharmacokinetics and safety in humans have yet to be well-documented in medical literature. Despite this, insights can be drawn from existing in vitro and in vivo animal studies on its pharmacokinetics.
Given the low cost of fenbendazole, its high safety profile, accessibility, and unique anti-proliferative activities, fenbendazole would be the preferred benzimidazole compound to treat cancer. To ensure patient safety in the repurposing use of fenbendazole, it is crucial to perform clinical trials to assess its potential anticancer effects, optimal doses, therapeutic regimen, and tolerance profiles.
This review focuses on the pharmacokinetics of orally administered fenbendazole and its promising anticancer biological activities, such as inhibiting glycolysis, down-regulating glucose uptake, inducing oxidative stress, and enhancing apoptosis in published experimental studies.
Additionally, we evaluated the toxicity profile of fenbendazole and discussed possibilities for improving the bioavailability of the drug, enhancing its efficacy, and reducing potential toxicity.
Fenbendazole for colon cancer Fenbendazole for colon cancer Fenbendazole for colon cancer