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Grape Seed Extract Kills Squamous Cell Head and Neck Cancer

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Grape Seed Extract selectively inhibited the growth and caused cell cycle arrest and apoptotic death in Head and Neck Cancer cells

If you are diagnosed with cancer head and neck cancer, your first goal is to reach remission. The newly diagnosed cancer patient wants to become cancer-free. Conventional oncology is usually pretty good at putting cancer patients into remission. At least the first time.

The problem is that many cancers return. The study linked and excerpted below explains that:

  1. recurrence of secondary primary tumors and
  2. resistance against conventional treatments

decrease the overall 5-year survival rate in Head and Neck Squamous Cell Cancer patients. In other words, you may reach remission once but if the cancer relapses you will be in trouble. Your cancer may not respond to more chemotherapy.

Image result for image of head and neck cancer

According to the study below, grapeseed extract kills head and neck cancer, is well-tolerated and is bioavailable. I am not talking about a silver bullet cure. I’m talking about supplementing with a nutritional therapy shown to reduce your risk of relapse.

Life Extension Grapeseed Extract w/ Resveratrol and Pterostilbene 100 MG, 60 Vcaps

I am a survivor of an incurable cancer called multiple myeloma. I have remained in complete remission from my cancer since 1999. I supplement with Life Extension Grapeseed Extract. I am also a cancer coach. Evidence-based, non-toxic therapies such as GSE are central to my living an evidence-based, non-toxic, anti-cancer lifestyle.

Have you been diagnosed with head and neck cancer? If so, what stage?

David Emerson

  • Cancer Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:


Generation of reactive oxygen species by grape seed extract causes irreparable DNA damage leading to G 2 /M arrest and apoptosis selectively in head and neck squamous cell carcinoma cells

“Head and neck squamous cell carcinoma (HNSCC) accounts for 6% of all malignancies in USA and unfortunately the recurrence of secondary primary tumors and resistance against conventional treatments decrease the overall 5 year survival rate in HNSCC patients

GSE selectively inhibited the growth and caused cell cycle arrest and apoptotic death in both Detroit 562 and FaDu cells…

In terms of its toxicity and bioavailability, in vivo studies with GSE have shown that it is well tolerated and is considered safe as dietary supplement for human consumption…

In summary, the present study clearly demonstrated GSE efficacy against HNSCC cells both in cell culture and animal models…Considering the limited therapeutic options available against HNSCC, results from the present study support additional studies investigating GSE efficacy against HNSCC both in chemoprevention and intervention protocols and define the mechanisms of its efficacy.”

 

 

Leave a Comment:

19 comments
Debbie Martin says last year

My husband had tongue surgery last year and the squamous cell has returned in a new tumor. What amount of GSE should be taken to stop this progression?

Reply
    David Emerson says last year

    Hi Debbie-

    According to research, Grape Seed Extract (GSE) reduces the risk of progression of squamous cell. All brands have different potency therefore I would take the recommended dose on the bottle.

    Good luck,

    David Emerson

    Reply
Dana says last year

I am going to try it for reaccuring Squamous on my legs and arms, what dosage is recommended?

Reply
    David Emerson says last year

    Hi Dana,

    I assume you are asking about a daily dose for grape seed extract? I take the dose recommended on the label. In other words, each bottle contains different sized capsules. Each brand may have a different GSE strength. I think the dose recommended on the bottle is the safest way to go.

    Good luck,

    David Emerson

    Reply
Mike aynes says last year

I have neck cancer no cure can’t operate didn’t take chemo or radiation will this grape seed help me possibly

Reply
    David Emerson says last year

    Hi Mike-

    Without knowing more about your cancer, symptoms, stage, etc. it is difficult for me to answer your question.But I will say that studies show grapeseed extract kills head and neck cancer cells and I can say from experience that nutrition, supplementation, lifestyle such as sauna, exercise, etc. can also kill your cancer while it helps to keep your immune system strong.

    Good luck,

    David Emerson

    Reply
Jerry says a couple of years ago

I’ve read several research articles on gse and squamous cell carcinoma, but no mention of the dosages used to actually kill the cancer cells. Do you have any knowledge of this?

Reply
    David Emerson says a couple of years ago

    Hi Jerry,

    The issue of dosage comes up with most every nutritional supplement that I blog about. Not just grapeseed extract but also curcumin, resveratrol, omega-3, etc. Almost every study I have read talks about “time and dose dependent manner.” This means that the more the subject takes and the longer the subject takes _______, the more cancer is killed.

    Further, most of the studies into nutritional supplementation are either in-vitro or in-vivo. Animal or test tube.

    My personal practice as a cancer survivor is to take the dose on the label. Keep in mind that I also exercise moderately, eat a nutritious diet, detox, etc. I take a shotgun approach…

    Thanks,

    David Emerson

    Reply
Head & Neck Cancer-Pembrolizumab Treats Relapsed Patients - PeopleBeatingCancer says 3 years ago

[…] Grape Seed Extract Kills Squamous Cell Head and Neck Cancer […]

Reply
Darin Kucey says 3 years ago

Hey David. I did not receive your email.

Reply
    David Emerson says 3 years ago

    Hi Darin,

    My apoligies. I bit off more than I could chew meaning there was more research to be done based on those 5 areas- in fact, I would like to add “integrative” therapies (curcumin/cisplatin) as well as nutritional supplementation such as curcumin that research shows is cytotoxic to oral/head and neck cancer.

    To skip to the bottom line, I was hoping to show you the benefits of you (the cancer patient) knowing about evidence-based but non-conventional issues and therapies. Not to criticise conventional oncology but your oncologist will talk to you only about FDA approved therapies such as radiation and chemotherapy (cisplatin). Those two therapies will probably cause a great deal of collateral damage aka side effects. Some side effects heal relatively quickly however some are permanent.

    Radiation to your neck may cause a side effect called dysphagea. Difficulty swallowing. My radiation to my neck did in my case. Two possible solutions. Resveratrol is a supplement shown to reduce the toxic side effects of radiation and a physical therapy can strengthen the neck/swallowing muscles.

    I would like to research these issues for OSSC. I am not asking you to do anything other than give my your opinion once you read the research. If you try one or more of the therapies I am hoping that again, you will give me your opinion/experience.

    I am a cancer survivor (differnt cancer) and cancer coach. I have created cancer coaching programs previously for my cancer (multiple myeloma) as well as pancreatic and lung cancers. I now want to research oral/head and neck cancer.

    Your oncologist is certainly your primary focus. I am simply asking if you are interested enough to read the research and tell me what you think.

    Let me know your thoughts. Thanks.

    David Emerson

    Reply
Darin Kucey says 3 years ago

I have SCC of the neck and back of my tongue. I had an operation that removed it in Oct 2017, but a year later it has come back and worse. I have been trying to do what I can with Natural supplements. I am scheduled to go in for radiation and chemo in 3 weeks but I really do not want to go that route.

Reply
    David Emerson says 3 years ago

    Hi Darin,

    I am sorry to learn of your oral SCC. As you can read below, the risk of recurrance for your cancer is about a third. The average five year survival is about 55%. That is an average and must be taken with a huge grain of salt. Meaning, your prognosis largelly depends on 1) if your SCC has spread to your lymphnodes and then 2) those therapies that you undergo from here on out.

    If you are not happy with a 55% five year average survival rate then I encourage you to undergo not only radiation and chemo but integrative and complementary shown to reduce your risk of side effects as well as enhance your conventional therapy (enhance your chemo and radiation).

    Grape seed extract, for example, is one of those evidence-based therapies that is cited to help.

    Do you know if your SCC is “locoregional” meaning it has spread to your lymphnodes? Has your oncologist mentioned what type of chemotherapy he/she would use?

    David Emerson

    The recurrence and survival of oral squamous cell carcinoma: a report of 275 cases

    “Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the head and neck, and recurrence is an important prognostic factor in patients with OSCC. We explored the factors associated with recurrence of OSCC and analyzed the survival of patients after recurrence…

    Reply
      Darin Kucey says 3 years ago

      Yes, it has spread to my lymph nodes. I have many nodes on both sides and the base of my neck but not sure how many are infected. They want to put me on cicplatin at the same time as radiation. Have always been very healthy with my diet, exercise, no smoking or drinking. They said it was from HPV+ virus.

      Reply
        David Emerson says 3 years ago

        Hi Darin,

        I am going to reply to your via your email.

        thanks

        David Emerson

        Reply
Kathy says 3 years ago

will this help destroy abnormal growths on the thyroid gland

Reply
    David Emerson says 3 years ago

    Hi Kathy,

    I can’t speak for the study linked in the blog post other than to say that resveratrol causes apoptosis to H&N cancer. Have you or a loved on been diagnosed with thyroid cancer?

    David Emerson

    Reply
William Wales says 3 years ago

Will this work on squamous cell carcinoma on my cats nose?

Reply
    David Emerson says 3 years ago

    Hi William,

    To be honest, I don’t know. I think its worth a try.

    David Emerson

    Reply
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