According to the studies linked and excerpted below, Green Tea, curcumin and resveratrol all cause apoptosis to bladder cancer cells. According to my experience, drinking a cup or two of green tea daily, eating curry for dinner (curcumin) or having a glass of red wine (resveratrol) will not amount to enough of the bladder cancer fighting green tea catechins in you.
Let me explain. I underwent cytoxan chemotherapy for my cancer years ago. A common side effect of cytoxan is an increased risk of bladder cancer. My risk increases slightly every year. I underwent cytoxan back in 1995 so my risk of bladder cancer is pretty high by now.
I supplement with Life Extension Mega Green Tea in order to reduce (or eliminate?) my risk of bladder cancer. As of the writing of this blog post it has been over 22 years since I underwent cytoxan. So far, so good.
According to the study linked and excerpted below, it’s really as simple as that. The study below uses all sorts of medical research language but long story short, after 72 hours, “treatment with catechin agents (Green Tea ) significantly suppressed cell growth in a dose-dependent fashion…Translation- The more you drink or the greater the dose of Green Tea extract, the more bladder cancer is killed.
Further, I take Life Extension Mega Green Tea Extract because this brand has been tested and approved by ConsumerLab.com an independent evaluation service. LEF Mega Green Tea has been well-reviewed on Amazon and is available through Amazon Prime (which I also use and recommend).
5% of anything you purchase on Amazon is donated to PeopleBeatingCancer, a 501C3 non-profit. Thank you.
I am both a cancer survivor and cancer coach. Personal experience has taught me that cancer patients and survivors benefit from the best of both conventional and evidence-based non-conventional cancer therapies.
If you are in remission from bladder cancer, or if you have been diagnosed, at any stage, with bladder cancer please read the study below and consider supplementing with this inexpensive therapy.
For more information about bladder cancer, both conventional and non-conventional therapies, please scroll down the page, post a question or comment and I will reply ASAP.
” This in vitro study examined the antiproliferative/pro-apoptotic potential of green tea extract (GTE), polyphenon-60 (PP-60), (-)-epicatechin gallate (ECG) and (-)-epigallocatechin-3-gallate (EGCG) in both normal and malignant human bladder cells…
Cell growth (proliferation/apoptosis) was measured in UROtsa (normal), SW780 (tumorigenic; low-grade), and TCCSUP (tumorigenic; high-grade) human bladder urothelial cells by cell proliferation (XTT) assay after treatment with 0-80 microg/mL of GTE, PP-60, ECG and EGCG for 72 h. Molecular signaling pathways of catechin-induced apoptosis were analyzed using Human signal transduction RT(2) Profiler PCR array (SuperArray). Compared to control-treated cells, treatment with catechin agents significantly suppressed cell growth in a dose-dependent fashion (P < 0.01), with strongest effects evoked by ECG and EGCG in UROtsa cells, ECG in low-grade RT4 and SW780 cells, and PP-60 and EGCG in high-grade TCCSUP and T24 cells…
Microarray analysis indicated distinct differences in mRNA gene expression regarding growth signaling pathway activation induced by EGCG in normal/tumorigenic human bladder cell lines, providing a rationale for the putative therapeutic usage of green tea polyphenols against bladder disease.”
“Bladder cancer has a considerable morbidity and mortality impact with particularly poor prognosis. Curcumin has been recently noticed as a polyphenolic compound separated from turmeric to regulate tumor progression.
However, the precise molecular mechanism by which curcumin inhibits the invasion and metastasis of bladder cancer cells is not fully elucidated. In this study, we investigate the effect of curcumin on the bladder cancer as well as possible mechanisms of curcumin….
In addition, bladder cancer cell lines T24 and 5637 cells were treated with different concentrations of curcumin. The cytotoxic effect of curcumin on cell proliferation of T24 and 5637 cells was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.
The migration and invasion capacity of T24 and 5637 cells were measured by transwell assay. The effects of curcumin on expression levels of β-catenin and epithelial–mesenchymal transition marker were determined by western blotting. The β-catenin expression was significantly upregulated in bladder cancer tissues when compared with corresponding peri-tumor tissues. Furthermore, curcumin inhibited the cell proliferation of T24 and 5637 cells, and curcumin reduced the migration and invasive ability of T24 and 5637 cells via regulating β-catenin expression and reversing epithelial–mesenchymal transition. Curcumin may be a new drug for bladder cancer.”
“The antitumor activity of resveratrol, a polyphenolic compound found mainly in grapes, has been studied in several types of cancer. In bladder cancer, its antiproliferative effects have already been demonstrated; however, its mechanism of action is not completely understood. The aim of this study was to evaluate resveratrol antitumor activity (12.5, 25, 50, 100, 150, 200, and 250 μM) and its possible mechanisms of action in bladder tumor cells with different TP53 gene status (RT4, grade 1, TP53 wild type; 5637-grade 2 and T24-grade 3, TP53 mutated)…
Resveratrol decreased cell proliferation and induced DNA damage in all cell lines.
Regarding the long-term effects, resveratrol reduced the number of colonies in all cell lines; however, TP53 wild type cells were more resistant. Increased rates of apoptosis were found in the TP53 wild type cells and this was accompanied by AKT, mTOR, and SRC downregulation…
In conclusion, resveratrol has antiproliferative activity in bladder tumor cells; however, the mechanisms of action are dependent on TP53 status.”