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Is HBOT curative for hemorrhagic cystitis? According to both the video and research linked below it can be. To be clear, I’m focusing on radiation-induced hemorrhagic cystitis (HC).
While radiation therapy was effective for zapping the lesions in my bone marrow (sacrum), long-term side effects such as HC occurred several years after my radiation therapy and bother me to this day.
Medical Minute: What is Radiation Cystitis?
What are possible symptoms of Hemorrhagic Cystitis?
Blood in the urine (hematuria) – Can range from pink-tinged urine to severe bleeding with blood clots.
Frequent urination – A strong urge to urinate more often than usual.
Pain or burning during urination (dysuria) – Discomfort or stinging sensation while urinating.
Lower abdominal or pelvic pain – Cramping or aching in the bladder area.
Urgency to urinate – Feeling the need to urinate immediately.
Difficulty urinating – Trouble starting or maintaining urine flow, sometimes due to blood clots.
Dark or cloudy urine – Due to blood or debris in the bladder.
Fever and chills (if an infection is present) – In cases where bacterial infection is involved.
Please don’t be surprised if your oncologist does not discuss HBOT with you as a therapy for HC. HBOT therapy may not be a therapy that your oncologist is familiar with.
Further, in my experience, oncology does a horrible job of talking to myeloma patients about possible side effects caused by conventional therapies.
The important thing for you to remember is that if you’ve undergone radiation to your pelvic region, undergo HBOT therapy ASAP. If your oncologist prescribes it, your insurance provider may even cover it.
“Background: Hemorrhagic cystitis (HC) is characterized by diffuse inflammation and bleeding of the lining of the urinary bladder. This study investigated hyperbaric oxygen therapy (HBOT) in patients with viral or radiation-induced HC.
Methods: A retrospective analysis was performed involving 33 patients diagnosed with HC who received HBOT. Data analysis involved the Kruskal-Wallis test and Spearman’s correlation coefficients to determine the strength of correlations between variables.
Results: Of the 33 patients, nine (27.3%) had radiation-induced HC, and 24 (72.7%) had viral HC. Among those with viral HC, 12 (50%) tested positive for BK virus by polymerase chain reaction (PCR). HBOT was performed in a multiplace hyperbaric chamber at 2.5 absolute atmospheres (ATA) for 90 to 120 minutes, and the median number of sessions was 11.
The median duration of treatment was 14 days, with 81.8% (n = 27) obtaining an improvement in macroscopic hematuria, 12.1% (n = 4) interrupting treatment, and 6.1% (n = 2) dying. HC did not recur in 57.6% of the sample (n = 19) in three years of follow-up.
A significant correlation was found between the degree of hematuria and the number of sessions required (p = 0.0025). Radiation-induced HC was associated with higher degrees of hematuria (p = 0.007). A correlation was found between etiology and recurrence after the conclusion of treatment (p = 0.029).
Conclusion: Identifying the cause of HC and classifying the degree of hematuria are important to planning the number of HBOT sessions needed for an improvement in symptoms and a reduction in the rate of recurrence after treatment. The present findings suggest clinical benefits from HBOT in the treatment of HC…
Conventional management of HC includes:
intravesical treatments, such as irrigation with 0.9% saline solution,
alum,
electrocauterization,
phenol, or formalin,
and systemic medication, such as tranexamic acid or corticoids [5].
However, these approaches often have limited success, especially in severe cases, and invasive procedures may be required, such as urinary diversion or cystectomy [6]…
All patients were treated by the same health team in the hospital setting. Patients underwent HBOT in a multiplace hyperbaric chamber at 2.5 absolute atmospheres (ATA) for 90 to 120 minutes. The number of sessions was determined based on the clinical response…
At the beginning of treatment, the median degree of hematuria was classified as grade III. The median quantity of HBOT sessions required was 11 (range: 5 to 20), and the median duration of treatment was 14 days (range: 7 to 28 days). With regard to the clinical outcome, 81.8% (n = 27) of the patients experienced an improvement in hematuria..
A significant correlation was found between etiology and the degree of hematuria, as radiation-induced HC was associated with higher degrees of hematuria (p = 0.007). No significant correlation was found between etiology and the number of HBOT sessions (p = 0.884). A significant difference between etiologies was observed in post-treatment recurrence (p = 0.029), with radiotherapy associated with a higher recurrence rate, suggesting that the etiology of HC influences the prognosis…
HBOT not only improved symptoms but also contributed to the tissue regeneration process, promoting angiogenesis and the deposition of fibroblasts in injured tissue [10,11]…
The safety of HBOT is widely documented in the literature, with a low incidence of side effects including middle ear barotrauma, sinus and paranasal sinus barotrauma, ocular side effects, hypoglycemia, oxygen-induced seizures, and claustrophobia [13]…
Conclusions
HBOT seems to be a safe and effective adjunct therapy for the treatment of viral and radiation-induced HC, leading to an improvement in hematuria and a reduction in refractiveness. Identifying the cause of HC and classifying the degree of hematuria are important to personalizing treatment and predicting outcomes.”
HBOT curative for hemorrhagic cystitis? HBOT curative for hemorrhagic cystitis?
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2 comments
Bindy Jeppo says
last month
Do you think that HBOT is good for MM patients even if they do not have radiation-induced hemorrhagic cystitis (HC)?
