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Hi Sheila-
I get info about supplements from the internet, specifically Pubmed. The studies sometimes list dose, often not. I often simply follow the dose listed on the label.
David Emerson
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Heart joint health is a priority for me. I am both a long-term survivor of Multiple Myeloma, a senior and I live with long-term side effects that result in joint and heart damage. A common ailment for us seniors is joint pain. Specifically, joint pain in our knees. And for many of us, heart failure aka cardiovascular disease may be a problem as well.
The challenge is to find inexpensive, effective therapies that help my heart health while easing my joint pain.
Consider evidence-based, non-toxic therapies shown to heal both your arthritis as well as your heart health.
All three nutritional supplements have been cited to ease joint pain as well as improve heart health.
To learn more about evidence-based non-toxic therapies shown to manage heart health, scroll down the page, post a question or comment and I will reply to you ASAP.
Thank you,
David Emerson
“Glucosamine (C6H13NO5) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Glucosamine is part of the structure of the polysaccharides, chitosan, and chitin. Glucosamine is one of the most abundant monosaccharides.[1] It is produced commercially by the hydrolysis of crustacean exoskeletons or, less commonly, by fermentation of a grain such as corn or wheat…”
“Objective To prospectively assess the association of habitual glucosamine use with risk of cardiovascular disease (CVD) events.
Main outcome measures Incident CVD events, including CVD death, coronary heart disease, and stroke.
Results During a median follow-up of seven years, there were
After adjustment for age, sex, body mass index, race, lifestyle factors, dietary intakes, drug use, and other supplement use, glucosamine use was associated with a significantly lower risk of total CVD events (hazard ratio 0.85, 95% confidence interval 0.80 to 0.90), CVD death (0.78, 0.70 to 0.87), coronary heart disease (0.82, 0.76 to 0.88), and stroke (0.91, 0.83 to 1.00).
Conclusion Habitual use of glucosamine supplement to relieve osteoarthritis pain might also be related to lower risks of CVD events…
Discussion
In this large prospective study, habitual glucosamine use was associated with a 15% lower risk of total CVD events and a 9%-22% lower risk of individual cardiovascular events (CVD death, CHD, and stroke). Such associations were independent of traditional risk factors, including sex, age, income, body mass index, physical activity, healthy diet, alcohol intake, smoking status, diabetes, hypertension, high cholesterol, arthritis, drug use, and other supplement use. In addition, we found that the associations between glucosamine use and CVD outcomes were statistically significantly modified by smoking status.
Comparison with other studies
Our findings are in line with several previous studies that show inverse associations of glucosamine use with CVD risk and mortality. In a cross sectional study of 266 844 Australian participants, glucosamine use was found to be inversely associated with risks of heart attack or angina (odds ratio 0.79, 95% confidence interval 0.73 to 0.86) and other heart diseases (0.82, 0.76 to 0.89).3 In the Vitamins and Lifestyle (VITAL) cohort study, glucosamine use was significantly associated with an 18% lower risk of total mortality.634 Similarly in our study, we found that glucosamine use was consistently associated with lower risks of subtypes of CHD, including fatal and non-fatal CHD. Our lack of statistically significant associations between glucosamine use and subtypes of stroke is probably because of small numbers of participants in the subtype groups…
Conclusions
Habitual use of glucosamine supplement to relieve osteoarthritis pain might also be related to lower risks of CVD events. Further clinical trials are needed to test this hypothesis.”
As a long-term cancer survivor I am drawn to the words “exercise” and “anti-inflammatory.” Anti-inflammatory nutritional supplementation has repeatedly shown evidence-based benefits.
Further, I can’t help but cite content on PBC that promotes a less is more approach to health. The Wall Street Journal article that is linked and excerpted below does both.
I cannot say anything about arthroscopic surgery for relieving pain because I have never had it. I exercise modestly (30 mins.) six times a week. Mounting studies cite the health benefits of both modest exercise and frequent exercise. According to the article below, in addition to keeping me cancer free, modest, frequent exercise also keeps me off the operating room table.
I take two nutritional supplements that have been shown to reduce inflammation.
For more information on nutritional supplementation to help manage cancer or help manage your collateral damage, scroll down the page, post a question or comment and I will reply ASAP.
thank you,
David Emerson
“Exercise and anti-inflammatory medications may be more effective than arthroscopic surgery for relieving pain from degenerative knee conditions in older patients, according to a meta-analysis in The BMJ, formerly the British Medical Journal…
Arthroscopic meniscectomy (knee surgery) was associated with rare but potentially serious complications in older patients. Deep-vein thrombosis was the most commonly reported problem, followed by infection, pulmonary embolism and death…
“Nearly half of Americans in their lifetimes will suffer from knee osteoarthritis, a disease that causes pain and stiffness; hip osteoarthritis will affect about a quarter of the population, according to the Centers for Disease Control and Prevention…
Several studies found a French company’s avocado-soy-oil blend can help pain for a period of three to six months. But two long-term studies have found it no better for relieving pain than a placebo…
The supplements, sold under a variety of brand names, go by the unwieldy name of avocado-soybean unsaponifiables, or ASU. In the laboratory, ASU have shown anti-inflammatory activity and also appear to help build joint cartilage and slow its destruction over time, says Jason Theodosakis…”
Hi Sheila-
I get info about supplements from the internet, specifically Pubmed. The studies sometimes list dose, often not. I often simply follow the dose listed on the label.
David Emerson
Reply