HPV Variable Risk Factor in Cervical Cancer

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“Human papillomavirus 16 accounts for about half of all cervical cancer, but researchers have found that not all infections are equal”

I guess I have always considered each “risk factor” to be equal.  By this I mean that all of same risk factors increased the risk of a specific cancer equally. I never considered risks to be “variable.” Not all HPV presents the same risk of cervical cancer according to the study discussed in the article linked and excerpted below. The very first paragraph says things like:

Electron micrograph of human papillomavirus (HPV). Courtesy of NCI. 1986.

  • Human papillomavirus 16 accounts for about half of all cervical cancers
  • but researchers have found that not all infections are equal
  • infected women have…variable risks to cancer
  • the vast majority of HPV16 sequences evaluated were unique to each infected woman

What does the author mean by HPV accounts for half of all cervical cancers? Does he/she mean that half of all  cervical cancers are caused by HPV? So when the very next sentence says that HPV risk is variable I take this to mean that a person can have the human papillomavirus and not have much of an increased risk of cervical cancer?

I found the last quotation of one of the study’s authors to be gauling. The author maintains that the research findings don’t change screening or vaccines. I couldn’t disagree more. If you have an HPV gene variant that is less of a risk than another 1) you are at less of a risk of cervical cancer and 2) you may be able to clear the virus more easily with a non-toxic, inexpensive supplement AHCC.

I am examining the study findings below for two reasons. Firstly, I had HPV when I was first diagnosed with multiple myeloma. Studies have shown that HPV increases the risk of this incurable blood cancer.

I supplemented with AHCC and I believe that I cleared the virus from my body. Secondly, as a cancer coach who encourages people with HPV to supplement with AHCC I would like to know how much this common sexually transmitted virus increases the risk of certain cancers.

Thank you,

David Emerson

  • Cancer Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

Recommended Reading:

Curcumin as Evidence-based Non-Conventional Cancer Therapy

Human papillomavirus 16 infections may pose variable cancer risk

“Human papillomavirus 16 accounts for about half of all cervical cancers, but researchers have found that not all infections are equal. An analysis of the HPV16 genome from 5,570 human cell and tissue samples revealed that the virus actually consists of thousands of unique genomes, such that infected women living in the same region often have different HPV16 sequences and variable risks to cancer

More than half a million women are diagnosed with cervical cancer, and more than 200,000 deaths occur each year. Nearly all cases of cervical cancer can be attributed to a persistent infection with one of a dozen high-risk HPV types, especially HPV16. However, it has not been clear why HPV16 poses a much greater cancer risk than other HPV types…

Remarkably, the vast majority of HPV16 sequences evaluated were unique to each infected woman…”There was an unexpectedly high level of HPV16 isolate diversity among women, which was surprising given the fact that the HPV16 genome replicates use the host cell machinery and has a slow mutation rate,” Mirabello says. “This has important clinical implications for HPV transmission patterns, viral clearance and persistence…”

The findings don’t change screening or vaccines at this point but could be important, for example, in understanding how to determine which HPV infections pose the greatest risk of producing cancer,..”

In First Human Trial, Mushroom Extract Cures HPV Infections

“It’s a potential breakthrough in treating the currently untreatable human papilloma virus (HPV) — one that comes directly from nature.

At a recent Society for Integrative Oncology conference, Judith A. Smith, a pharmacist and an associate professor at the University of Texas Health Science Center at Houston Medical School, presented the results of a small study that found the supplement active hexose correlated compound (AHCC) can eliminate the HPV virus…”

Second Cancer Increasingly Common Among HPV-related Cancer Survivors

“Adults who survived HPV-associated cancers appeared at a significant risk for HPV-associated second primary cancers, according a retrospective cohort study.

Additionally, the risk for developing most types of HPV-associated second primary cancers has increased over the last 4 decades…

Of the 73,085 women survivors of HPV-associated cancers, 1,397 developed HPV-associated second primary cancers. Of the 40,187 men survivors, 1,098 developed second cancers.

Researchers observed standard incidence ratios (SIRs) for HPV-associated second cancers of 6.2 (95% CI, 5.9-6.6) among women and 15.8 (95% CI, 14.9-16.8) among men…”




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