we describe an alternative, curcumin (diferuloylmethane), a component of turmeric (Curcuma longa) that is inexpensive, orally bioavailable and highly safe in humans, yet can block TNF-α action
I had to find out the hard way. I had to experience all the side-effects of chemotherapy and radiation before I truly understood how dangerous chemoradiation was. In my defense the collateral damage caused by chemoradiation entailed long-term and late stage damage that my oncologist never explained could happen. I’m not sure that even Dr. Berger understood the damage my body would sustain from the toxic therapies that he prescribed. After all, I’ve outlived all of the conventional oncological predictions.
If you take Humira or Enbrel you may be in the same position I was in. Sure, you say to yourself, “there are side effects but nothing I can’t manage.” Or maybe you and your doctor don’t even know the long term damage of these drugs.
Keep in mind that this isn’t necessarily an all or nothing proposition. In many cancers curcumin enhances the efficacy of certain chemotherapies while it moderates the toxicities.
I often say to myself, “if I knew then what I know now...”
I am a long-term cancer survivor and cancer coach. I take Life Extension Super Bio Curcumin for it’s bioavailability. It has been tested and approved by Consumerlab.com, an independent testing agency.
For more information about integrative therapies to moderate inflammation, scroll down the page, post a question or comment and I will reply ASAP.
thank you,
David Emerson
- Cancer Survivor
- Cancer Coach
- Director PeopleBeatingCancer
“TNFs are major mediators of inflammation and inflammation-related diseases, hence, the United States Food and Drug Administration (FDA) has approved the use of blockers of the cytokine, TNF-α, for the treatment of osteoarthritis, inflammatory bowel disease, psoriasis and ankylosis.
These drugs include the chimeric TNF antibody (infliximab), humanized TNF-α antibody (Humira) and soluble TNF receptor-II (Enbrel) and are associated with a total cumulative market value of more than $20 billion a year.
As well as being expensive ($15 000-20 000 per person per year), these drugs have to be injected and have enough adverse effects to be given a black label warning by the FDA. In the current report, we describe an alternative, curcumin (diferuloylmethane), a component of turmeric (Curcuma longa) that is very inexpensive, orally bioavailable and highly safe in humans, yet can block TNF-α action and production in in vitro models, in animal models and in humans.
In addition, we provide evidence for curcumin‘s activities against all of the diseases for which TNF blockers are currently being used. Mechanisms by which curcumin inhibits the production and the cell signalling pathways activated by this cytokine are also discussed. With health-care costs and safety being major issues today, this golden spice may help provide the solution.”
APPIP ERROR: amazonproducts[
AccessDeniedAwsUsers|The Access Key Id AKIAJAJ37JVNL7OUU4CA is not enabled for accessing this version of Product Advertising API. Please migrate your credentials as referred here https://webservices.amazon.com/paapi5/documentation/migrating-your-product-advertising-api-account-from-your-aws-account.html.
]
