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Inflammation- Brain, Skin, Heart, Cancer…

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“therefore, the targeting of inflammation (infla) represents an attractive strategy both for cancer prevention and for cancer therapy…”

Inflammation. I am a long-term survivor of an incurable blood cancer called multiple myeloma. Four years of conventional treatments including an autologous stem cell transplant gave me nothing but a series of short, long-term and late stage side effects.

Inflammation is at the heart of my cancer as well as each and every one of my side effects. The studies linked and excerpted below give my thinking the weight of credible research.

The solution? Anti-inflammatory nutrition and supplementation. This is to say that I eat a diet of fruits and veggies daily. I supplement with anti-inflammatory supplements such as curcumin, omega-3 fatty acids, resveratrol, etc.

I often lament “I wish I knew then what I know now.” It took me a decade of research and writing PeopleBeatingCancer.org to figure out that an anti-inflammatory lifestyle would help me manage my side effects while reducing or even eliminating my risk of both my original cancer as well as several treatment-related secondary cancers.

My years of research and writing about inflammation and various side effects is contained in the 14 blog posts linked below.

  1. Anti-Aging or Anti- Immune System Aging?
  2. Are Anti-Aging Therapies such as N.A.D., Legit?
  3. Melatonin As Anti-Aging Therapy for Age-Related Bone Loss
  4. Resveratrol = Anti-Aging, Slow Multiple Myeloma, Slow chronic disease?
  5. MM- Anti-aging- Diet, Supplements, Sleep, Exercise
  6. Healing Chemotherapy-Induced Aging-
  7. Can Childhood, AYA Cancer Survivors Heal Frailty, Cognitive Decline?
  8. Collagen-Skin, Muscle, Joint, Brain and Heart Health
  9. Chemotherapy Ages Breast Cancer Patients 10-15 years?!?!
  10. Coffee, Improve Skin, Reduce Skin Cancer Risk-
  11. Reduce Chronic Inflammation to Reduce Parkinson’s Disease?
  12. C-B-D, Inflammation and Alzheimer’s
  13. Reduce Brain Inflammation, Reduce Risk of Depression, Risk of Suicide

Do you have cancer? Short, long-term or late stage side effects? Are you worried about developing chemotherapy-induced cardiomyopathy or chemo brain or your own secondary cancer?

Scroll down the page, post a question or a comment and I will reply to you ASAP.

Hang in there.

David Emerson

  • Cancer Survivor
  • Cancer Coach
  • Director PeopleBeatingCancer

Inflammation- wikipedia

“Disorders- Inflammatory abnormalities are a large group of disorders that underlie a vast variety of human diseases. The immune system is often involved with inflammatory disorders, as demonstrated in both allergic reactions and some myopathies, with many immune system disorders resulting in abnormal infla. Non-immune diseases with causal origins in inflammatory processes include cancer, atherosclerosis, and ischemic heart disease.[12]

Inflammation and Cancer

“Infla is often associated with the development and progression of cancer. The cells responsible for cancer-associated inflammation are genetically stable and thus are not subjected to rapid emergence of drug resistance; therefore, the targeting of inflammation represents an attractive strategy both for cancer prevention and for cancer therapy.

Tumor-extrinsic infla is caused by many factors, including bacterial and viral infections, autoimmune diseases, obesity, tobacco smoking, asbestos exposure, and excessive alcohol consumption, all of which increase cancer risk and stimulate malignant progression.

In contrast, cancer-intrinsic or cancer-elicited infla can be triggered by cancer-initiating mutations and can contribute to malignant progression through the recruitment and activation of inflammatory cells.

Both extrinsic and intrinsic inflammations can result in immunosuppression, thereby providing a preferred background for tumor development. The current review provides a link between inflammation and cancer development…”

Intake and Sources of Dietary Fiber, Inflammation, and Cardiovascular Disease in Older US Adults

Importance  Higher intake of dietary fiber has been associated with lower inflammation, but whether there are differences in this association by source of dietary fiber (ie, cereal, vegetable, or fruit) has not been studied to date.

Objectives  To evaluate the associations of total fiber intake and source (ie, cereal, vegetable, and fruit fiber intake) with inflammation and to evaluate whether inflammation mediates the inverse association between dietary fiber intake and cardiovascular disease (CVD)…

Exposures  Total fiber intake and sources of fiber (cereal, vegetable, and fruit).

Main Outcomes and Measures  Systemic markers of inflammation. Cardiovascular disease was the outcome in the mediation analysis.

Results  Of 4125 individuals… an increase in total fiber intake of 5 g/d was associated with significantly lower concentrations of C-reactive protein (adjusted mean difference, −0.05 SD; 95% CI, −0.08 to −0.01 SD; P = .007) and interleukin 1 receptor antagonist (adjusted mean difference, −0.04 SD; 95% CI, −0.07 to −0.01 SD; P < .02) but with higher concentrations of soluble CD163 (adjusted mean difference, 0.05 SD; 95% CI, 0.02-0.09 SD; P = .005). Among fiber sources, only cereal fiber was consistently associated with lower inflammation. Similarly, cereal fiber intake was associated with lower CVD incidence (adjusted hazard ratio, 0.90; 95% CI, 0.81-1.00; 1941 incident cases).

The proportion of the observed association of cereal fiber with CVD mediated by inflammatory markers ranged from 1.5% for interleukin 18 to 14.2% for C-reactive protein, and 16.1% for their primary principal component.

Conclusions and Relevance  Results of this study suggest that cereal fiber intake was associated with lower levels of various inflammatory markers and lower risk of CVD and that inflammation mediated approximately one-sixth of the association between cereal fiber intake and CVD…”

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