Recently Diagnosed or Relapsed? Stop Looking For a Miracle Cure, and Use Evidence-Based Therapies To Enhance Your Treatment and Prolong Your Remission
Multiple Myeloma an incurable disease, but I have spent the last 25 years in remission using a blend of conventional oncology and evidence-based nutrition, supplementation, and lifestyle therapies from peer-reviewed studies that your oncologist probably hasn't told you about.
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Ivermectin and myeloma. Myeloma and ivermectin. Could there be something to this anti-parasitic drug that is a sensation on the internet!?
First and foremost, I have to stress that Ivermectin has not been approved by the FDA as a myeloma therapy. And the list of side effects below can more than challenge a list of side effects for many chemotherapy drugs.
Now that I have gotten that caveat out of the way, I have to say that the research below certainly makes Ivermectin out to be a viable therapy for MM patients. Especially those MM patients who have relapsed more than once.
Which chemotherapy regimens are synergized by ivermectin?
Doxorubicin: Ivermectin has been found to enhance the efficacy of doxorubicin in various cancer models, such as breast cancer, by increasing the drug’s ability to induce apoptosis in cancer cells.
Cisplatin: Studies have shown that ivermectin can synergize with cisplatin, a commonly used chemotherapy drug, enhancing its cytotoxic effects on cancer cells, including ovarian and lung cancers.
Paclitaxel: In preclinical models, ivermectin has been shown to enhance the anticancer effects of paclitaxel, a drug commonly used in the treatment of breast and ovarian cancers.
Vincristine: Ivermectin may also enhance the efficacy of vincristine, a chemotherapy agent used in the treatment of various cancers, including leukemia and lymphoma.
5-Fluorouracil (5-FU): There is evidence suggesting that ivermectin may synergize with 5-FU, commonly used in the treatment of colorectal and other gastrointestinal cancers, by promoting cancer cell death.
Tamoxifen: In some studies, ivermectin has been shown to work synergistically with tamoxifen, a hormonal therapy used in estrogen receptor-positive breast cancer.
As a somewhat cynical MM survivor, I have to believe that no for-profit drug company will go to the time, trouble and expense of putting on a clinical trial for Ivermectin. However, again speaking as a cancer patient, I have to say that any therapy that has the ability to reduce or eliminate multi-drug resistance must be clinically trialed.
Are you a MM survivor who has undergone ivermectin? What do you think of this drug therapy? Email me at David.PeopleBeatingCancer@gmail.comand let me know.
“Discovery and development of novel drugs that are capable of overcoming drug resistance in tumor cells are urgently needed clinically. In this study, we sought to explore whether ivermectin (IVM), a macrolide antiparasitic agent, could overcome the resistance of cancer cells to the therapeutic drugs…
Results-Our results indicated that ivermectin at its very low dose, which did not induce obvious cytotoxicity, drastically reversed the resistance of the tumor cells to the chemotherapeutic drugs both in vitro and in vivo. Mechanistically, ivermectin reversed the resistance mainly by reducing the expression of P-glycoprotein (P-gp) via inhibiting the epidermal growth factor receptor (EGFR), not by directly inhibiting P-gp activity. Ivermectin bound with the extracellular domain of EGFR, which inhibited the activation of EGFR and its downstream signaling cascade ERK/Akt/NF-κB. The inhibition of the transcriptional factor NF-κB led to the reduced P-gp transcription.
Conclusions-These findings demonstrated that ivermectin significantly enhanced the anti-cancer efficacy of chemotherapeutic drugs to tumor cells, especially in the drug-resistant cells. Thus, ivermectin, a FDA-approved antiparasitic drug, could potentially be used in combination with chemotherapeutic agents to treat cancers and in particular, the drug-resistant cancers.”
Ivermectin effectively suppresses the proliferation and metastasis of cancer cells and promotes cancer cell death at doses that are nontoxic to normal cell
Ivermectin shows excellent efficacy against conventional chemotherapy drug-resistant cancer cells and reverses multidrug resistance.
Ivermectin combined with other chemotherapy drugs or targeted drugs has powerful effects on cancer.The structure of crosstalk centered on PAK1 kinase reveals the mechanism by which ivermectin regulates multiple signaling pathways.
Ivermectin has been used to treat parasitic diseases in humans for many years and can quickly enter clinical trials for the treatment of tumors…”
“Ivermectin is a medication that treats some parasitic diseases. There are two types of the medication. Doctors prescribe one kind for certain health conditions in people, and veterinarians prescribe another that’s safe only for animals…
What Are the Side Effects of Ivermectin?
At doses that doctors usually prescribe for people, ivermectin can have side effects like:
Thank you for giving me some hope. I understand that Ivermectin is not available here in Australia but just 4 weeks ago I opted to try the Tippens protocol at 220mg per day and yesterday I upt my dose to 2x a day in the am and in the pm I also am taking thc at nighr and lenidamide. Any advice you cd add wd be most welcome
Presently Im reading Jane McClellands book How to Starve Your Cancer. Also still into your writings. The bit that has been for so long kept in the dark is MM I thank you for shining the light on this dark roadway.
Grateful
