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One of many long-term side effect sustained from my high-dose aggressive chemotherapy in ’95-’96 was chemotherapy-induced cognitive dysfunction aka chemobrain. I work to prevent dementia in any form. At 62, I’m still a bit young for Alzheimer’s Disease (AD).
But while my chemobrain has certainly improved over the past 30 plus years, I spend much of my day thinking about how to improve my brain health. When I come across articles and studies like the ones linked and excerpted below, I use them to write a blog post.
PeopleBeatingCancer.org in general and cancer coaching in particular is my Life Purpose. Spending minutes or hours with cancer patients working through everything from therapies (chemo, radiation, surgery, nutrition, supplementation, etc.) to big picture challenges such as financial toxicity or their emotional health is why I need to live as long as I can with a healthy brain.
My day is filled with:
all designed to help me help patients help me… And over and over again, day-in, day-out. After 30 plus years I’m not sure who helps whom more…
Are you a cancer patient or caregiver? Scroll down the page, post a question or a comment and I will reply to you ASAP.
“New research shows that positive mental well-being may help protect brain health as we age.
The findings strongly linked having purpose and meaning in life with a reduced risk for mild cognitive impairment and dementia.
Meaningful activities that engage the mind, body, and spirit may help prevent Alzheimer’s disease and other dementias…
The meaning of life might just be about finding meaning in life itself.
A new meta-analysis in Ageing Research Reviews suggests that a life lived with purpose and meaning is good for brain health, offering implications for cognitive impairment in older adults.
According to the National Institute on AgingTrusted Source, people over 65 will account for 16% of the world’s population by 2050 — a 50% increase from 2010. The global prevalence of Alzheimer’s disease and other dementias is expected to triple by 2050Trusted Source, from about 57 million to 152 million…
The systematic review of 11 studies observed the link between positive psychological constructs (PPCs) like purposeful living and the risk of dementia and mild cognitive impairment (MCI) in older adults.
The results indicate that having purpose and meaning in life is significantly associated with a 19% reduced risk for dementia. This was more statistically significant than other positive constructs like optimism and happiness…
Georgia Bell, a PhD student at University College London and lead author of the study, told Psych Central that purposeful living may be more impactful for reducing MCI risk than happiness due to the differences between eudemonic (e.g., purpose or meaning) and hedonic (e.g., positive affect or pleasure) well-being.
“People with higher eudemonic well-being may be more likely to engage in other protective behaviors, such as exercise and social interactions,” Bell said by email.
“Whilst an individual may gain happiness from these, the goal-oriented pursuit to live in a way that is purposeful [or] meaningful may act as motivation to live a healthier lifestyle…”
If having purpose or meaning in life leads to better brain health, it’s possible that biological and neurological factors play a role.
For instance, a study published in April 2022 in Frontiers in Behavioral Neuroscience shows that life satisfaction increases with age due to the increased release of oxytocin.
According to Bell, it’s possible that purpose and meaning are also associated with key dementia-related biomarkers, such as neuroinflammation and cellular stress response…”
“Happiness has little to do with it. Research suggests meaning in your life is important for well-being.
My favorite medical diagnosis is “failure to thrive.”
Not because patients are failing to thrive — that part makes me sad. But because of the diagnosis’s bold proposition: Humans, in their natural state, are meant to thrive.
My patient, however, was not in his natural state. Cancer had claimed nearly every organ in his body. He’d lost a quarter of his body mass. I worried his ribs would crack under the weight of my stethoscope.
“You know,” he told me the evening I admitted him. “A few years ago, I wouldn’t have cared if I made it. ‘Take me God,’ I would’ve said. ‘What good am I doing here anyway?’ But now you have to save me. Sadie needs me.”
He’d struggled with depression most of his life, he said. Strangely enough, it seemed to him, he was most at peace while caring for his mother when she had Parkinson’s, but she died years ago. Since then, he had felt aimless, without a sense of purpose, until Sadie wandered into his life.
Sadie was his cat.
Only about a quarter of Americans strongly endorse having a clear sense of purpose and of what makes their lives meaningful, while nearly 40 percent either feel neutral or say they don’t. This is both a social and a public health problem: Research increasingly suggests that purpose is important for a meaningful life — but also for a healthy life.
Purpose and meaning are connected to what researchers call eudaimonic well-being. This is distinct from, and sometimes inversely related to, happiness (hedonic well-being). One constitutes a deeper, more durable state, while the other is superficial and transient.
Being a pediatric oncologist, for example, is not a “happy” job, but it may be a very rewarding one. Raising a family can be profoundly meaningful, but parents are often less happy while interacting with their children than exercising or watching television.
Having purpose is linked to a number of positive health outcomes, including better sleep, fewer strokes and heart attacks, and a lower risk of dementia, disability and premature death. Those with a strong sense of purpose are more likely to embrace preventive health services, like mammograms, colonoscopies and flu shots.
And people with high scores on measures of eudaimonic well-being have low levels of pro-inflammatory gene expression; those with high scores on hedonic pleasure have just the opposite.
Doing good, it seems, is better than feeling good.
One study analyzed how having purpose influences one’s risk of dementia. Researchers assessed baseline levels of purpose for 951 individuals without dementia, then followed them for seven years, controlling for things like depression, neuroticism, socioeconomic status and chronic disease. Those who had expressed a greater sense of purpose were 2.4 times less likely to develop Alzheimer’s, and were far less likely to develop even minor cognitive problems.
Another study followed more than 6,000 individuals over 14 years and found that those with greater purpose were 15 percent less likely to die than those who were aimless, and that having purpose was protective across the life span — for people in their 20s as well as those in their 70s.
Having purpose is not a fixed trait, but rather a modifiable state: Purpose can be honed through strategies that help us engage in meaningful activities and behaviors. This has implications at both the dinner table and the hospital bed.
A recent randomized control trial compared the effect of “meaning-centered” versus “support-focused” group therapy for patients with metastatic cancer. Patients in the support groups met weekly and discussed things like “the need for support,” “coping with medical tests” and “communicating with providers.”
Patients in the meaning-centered groups focused instead on spiritual and existential questions. They explored topics like “meaning before and after cancer,” “what made us who we are today,” and “things we have done and want to do in the future.” Meaning-centered patients experienced fewer physical symptoms, had a higher quality of life, felt less hopeless — and were more likely to want to keep living.
Other research suggests that school programs that allow students to discuss positive emotions and meaningful experiences may enhance psychological well-being, and protect against future behavioral challenges. But this isn’t how we usually operate. We instead assume that anxiety and depression are problems to be treated — not that emotional resilience and human flourishing are states to be celebrated.
What’s powerful about these conversations is not just that they can help cancer patients through treatment or help teenagers build resiliency — they can also help the rest of us. We should all consider asking ourselves and our loved ones these questions more often.
During my most trying months of medical school, I met every Sunday evening with three friends. Phones off, lights dim, wine glasses full. We shared the most challenging and most rewarding moments of our weeks. These conversations helped each of us glean — or perhaps create — meaning in challenging, sometimes traumatic, experiences: the death of a child we’d cared for; abusive language from a superior; the guilt of committing a medical error.
It was in these sessions that I chose my specialty, decided to apply to policy school, and vowed to reconnect with a lost friend.
Meaning grows not just from conversation, of course, but also from action. One recent study randomly assigned 10th graders to volunteer weekly with elementary students — to help with homework, cooking, sports, or arts and crafts — or put them on a wait list.
Teenagers who volunteered had lower levels of inflammation, better cholesterol profiles and lower body mass index. Those who had the biggest jumps in empathy and altruism scores had the largest reductions in cardiovascular risk.
Engaging in these kinds of activities may be most important for individuals whose identity is in flux, like parents with children leaving for college or workers preparing for retirement. A program run by Experience Corps, an organization that trains older adults to tutor children in urban public schools, has shown marked improvements in mental and physical health among tutors. The improvements included higher self-esteem, more social connectedness, and better mobility and stamina. (The children do better, too.)
This work hints at an underlying truth: Finding purpose is rarely an epiphany, nor is it something you pick up at the mall or download from the app store. It can be a long, arduous process that requires introspection and conversation, then a commitment to act.
The key to a deeper, healthier life, it seems, isn’t knowing the meaning of life — it’s building meaning into your life. Even if meaning is a four-legged friend named Sadie.”