Lymphatic problems cause chemobrain?

Systemic chemotherapy often affects cells beyond the tumor, raising concerns about their impact on peripheral tissues, including the central nervous system (CNS). The meningeal lymphatics drain cerebrospinal fluid from the CNS to the deep cervical lymph nodes, assisting in immunosurveillance and linking the CNS to the periphery.

They have been implicated in a number of brain-related disorders with disruption exacerbating cognitive deficits. However, in vivo, distinguishing between direct and indirect effects of systemic chemotherapy on the meningeal lymphatics remains highly challenging, making it difficult to isolate specific impact on the CNS.

To address this, we present two models we have developed that allow the examination of cellular and tissue-level changes to study the effects of systemic chemotherapy on the meningeal lymphatics. Our in vitro tissue engineered model representative of a meningeal lymphatic vessel lumen shows cell disruption, while our ex vivo model culturing mouse meningeal layers probes structural changes in a controlled setting. Finally, we correlate functional outcomes with observed changes in vivo and show that systemic taxane chemotherapy leads to morphological changes in the meningeal lymphatics, a trend of reduced flow through the brain, and impaired cognition, emphasizing the need for further study of off-target impacts in the CNS and the value of multi-model approaches…

Conclusion

We have presented a three-tiered approach toward studying the meningeal lymphatics, which is an area of great interest in understanding CNS malignancy. In vivo studies allow for systemic treatment and tissue-level analysis. The ex vivo component allows for imaging of uptake and tissue-level structural insights, while providing a higher ease of experimentation in a controllable manner.

Our in vitro meningeal lymphatic model allows examination on a cellular level, higher throughput, and customization based on application. Further, we have shown that the meningeal lymphatics have differing responses to platinum and taxane chemotherapy compared to other lymphatic systems in the body, thus demonstrating off-target effects on the CNS that require future studies.

Finally, we have demonstrated that disruption of the meningeal lymphatics post-chemotherapy is directly correlated with cognitive dysfunction. This dysfunction, called “chemobrain” is commonly experienced by patients undergoing systemic chemotherapy treatment. Further study is required to determine how to protect this vital drainage system to reduce these devastating side effects.

THE BEST EXERCISES FOR LYMPHATIC DRAINAGE AND SWELLING

The lymphatic system is essential for our health and well-being. It helps process and remove waste products from our blood stream, which is a key role in the immune system and our overall health. However, the lymph nodes can be affected by several health issues or interventions (such as cancer treatment), which can cause severe and painful swelling called lymphedema.

Lymphedema can appear anywhere in the body, including the neck and head area. When it affects the limbs, lymphatic drainage massage and compression therapy can help stimulate circulation, move excess lymph fluid back into the vessels, and reduce swelling and discomfort. Additionally, there are exercises you can do to support your circulatory system and counter the effects of a sedentary lifestyle or being immobile for longer periods.

Here we’ll look at the benefits of lymphatic drainage exercises, the best type of physical activity you can do to maintain healthy circulation, and some top exercises and tips for countering leg lymphedema…

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Lymphatic problems cause chemobrain?

What Causes Chemo Brain After Colorectal Cancer Treatment?

Demonstration of chemotherapeutic-mediated changes in meningeal lymphatics in vitro, ex vivo, and in vivo

Abstract

Conclusion

THE BEST EXERCISES FOR LYMPHATIC DRAINAGE AND SWELLING

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